Clinical Trials

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Nerve Tissue, Recurrence, Central Nervous System Neoplasms

NCT06161519 2026-03-17

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

146 enrolled

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Recurrence

NCT05588141 2026-03-13

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

96 enrolled

Brain Neoplasms, Glioma, Neoplasms, Recurrence

NCT05660408 2026-03-09

RNA PRIME

36 enrolled

Brain Neoplasms, Glioma

NCT05987644 2026-03-09

DURABLE

56 enrolled

Brain Neoplasms, Lung Neoplasms

NCT05789589 2026-03-04

ADORATION

46 enrolled

Brain Neoplasms, Neoplasm Metastasis, Neoplasms

NCT04238819 2026-03-02

A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma

47 enrolled 36 charts

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT06047379 2026-03-02

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

CNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

134 enrolled

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Astrocytoma, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Melanoma, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Central Nervous System Neoplasms, Small Cell Lung Carcinoma

NCT05593094 2026-02-25

A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors

210 enrolled

Brain Neoplasms

NCT02942264 2026-02-23

Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma

53 enrolled 22 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Recurrence, Gliosarcoma

NCT03510208 2026-02-09

Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery

46 enrolled

Brain Neoplasms, Glioma

NCT04478279 2026-02-09

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

BreastCNSDermatologicGenitourinary

125 enrolled

Brain Neoplasms, Breast Neoplasms, Glioblastoma, Melanoma, Prostatic Neoplasms

NCT04923542 2026-02-06

Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases

31 enrolled

Brain Neoplasms

NCT05386108 2026-02-05

ELECTRA

73 enrolled

Brain Diseases, Brain Neoplasms, Breast Diseases, Breast Neoplasms, Central Nervous System Diseases, Neoplasms, Neoplasms by Site, Central Nervous System Neoplasms

NCT06810544 2026-02-02

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

191 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Glioma, Lung Neoplasms

NCT05588453 2026-01-12

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

30 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT03277638 2026-01-08

Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM)

32 enrolled

Brain Neoplasms, Glioblastoma

NCT02650401 2025-12-24

STARTRK-NG

CNSEndocrineGenitourinaryHead & NeckSarcoma

69 enrolled 1 FDA

Thyroid Cancer, Papillary, Brain Neoplasms, Glioma, Medulloblastoma, Neoplasm Metastasis, Wilms Tumor, Neuroblastoma, Recurrence, Salivary Gland Neoplasms, Sarcoma, Sarcoma, Ewing, Central Nervous System Neoplasms, Nephroma, Mesoblastic

NCT04711824 2025-12-23

SOLARA

41 enrolled

Brain Neoplasms, Breast Neoplasms

NCT04538742 2025-12-08

DB-07

245 enrolled

Brain Neoplasms, Breast Neoplasms

NCT06194929 2025-12-03

DETERMINE

33 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT07206498 2025-11-28

WAYWIN103

48 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT04085887 2025-11-18

Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures

12 enrolled

Brain Neoplasms

NCT02696993 2025-11-10

Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer

80 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT02285439 2025-10-07

Study of MEK162 for Children With Low-Grade Gliomas

105 enrolled 17 charts

Brain Neoplasms, Soft Tissue Neoplasms

NCT05630209 2025-10-02

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)

Phase 1/2 Not yet recruiting

Brain Neoplasms

NCT07177950 2025-09-17

A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases

51 enrolled

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT04977375 2025-09-03

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

Brain Neoplasms, Glioblastoma, Glioma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT01478178 2025-08-29

Safety Study of VAL-083 in Patients With Recurrent Malignant Glioma

55 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT06907043 2025-08-19

EIK1004-001

130 enrolled

Brain Neoplasms

NCT01891318 2025-07-02

Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study

36 enrolled

Brain Neoplasms

NCT05615623 2025-04-30

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG

Brain Neoplasms

NCT05535413 2025-04-25

UTD1 Combined With Capecitabine in Metastatic HER2-negative Breast Cancer Patients With Brain Metastases

30 enrolled

Brain Neoplasms

NCT03449238 2025-04-24

Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients

41 enrolled

Brain Neoplasms, Breast Neoplasms

NCT03508752 2025-04-16

Neurocognitive Decline in Patients With Brain Metastases

80 enrolled

Brain Neoplasms

NCT02861898 2025-04-09

Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma

33 enrolled

Brain Neoplasms, Glioblastoma

NCT03213002 2025-04-09

CAPTEM

67 enrolled

Brain Neoplasms, Glioblastoma, Neoplasms

NCT05669352 2025-04-04

A Study of Oral IRAK-4 Inhibitor CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery in Patients With Melanoma Brain Metastases

Phase 1/2 Suspended

29 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT01906385 2025-03-26

Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)

55 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT03046992 2025-03-21

Clinical Trial of YH25448 in Patients with EGFR Mutation Positive Advanced NSCLC

224 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT03150862 2025-02-04

A Study Assessing Pamiparib With Radiation and/or Temozolomide (TMZ) in Participants With Newly Diagnosed or Recurrent Glioblastoma

116 enrolled 31 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Nervous System Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Gliosarcoma

NCT03276676 2024-12-27

[18F]Fluciclovine and [18F]FLT PET/CT Assessment of Primary High-Grade Brain Tumors

10 enrolled 7 charts

Brain Neoplasms

NCT01217411 2024-11-19

RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

BreastCNSDermatologicThoracic

5 enrolled 6 charts

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Breast Neoplasms, Male, Small Cell Lung Carcinoma

NCT06012695 2024-11-14

NBM-BMX Administered Orally to Patients with Solid Tumors or Newly Diagnosed Glioblastoma

79 enrolled

Brain Neoplasms, Neoplasms

NCT06640582 2024-11-05

BAH2472

85 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Meningioma

NCT02052648 2024-03-27

Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors

160 enrolled 21 charts

Phase 1/2 Not yet recruiting

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT06329570 2024-03-26

Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM)

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms, Nerve Tissue

NCT06243003 2024-02-07

WBRT With Hippocampal-avoidance Technique Followed by SRT for Extensive-stage SCLC With Baseline Brain Metastases

56 enrolled

Brain Neoplasms

NCT02768337 2024-01-31

CamBMT1