Clinical Trials

24 enrolled

Brain Neoplasms

NCT04738162 2025-12-10

Clinical Safety Study on 5-Aminolevulinic Acid (5-ALA) in Children and Adolescents With Brain Tumors

78 enrolled

Brain Neoplasms

NCT04503772 2025-12-04

STEP

70 enrolled

Brain Neoplasms

NCT06439420 2025-10-01

CBT-I in PBT

70 enrolled

CNSLymphoid

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Sleep Initiation and Maintenance Disorders, Lymphoma, Meningioma, Oligodendroglioma

NCT03050736 2025-09-04

Safety Study of VAL-083 and Radiotherapy in Patients With Newly Diagnosed GBM Having Unmethylated MGMT Expression

29 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT02717962 2025-08-29

Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Glioblastoma in the Adjuvant or Recurrent Setting

118 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT01931098 2025-08-11

Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab

35 enrolled 13 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT03967522 2025-08-08

CABRAMET

26 enrolled

CNSGenitourinary

Brain Neoplasms, Carcinoma, Renal Cell

NCT02681549 2025-08-07

Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer (NSCLC)

41 enrolled 20 charts

CNSDermatologicThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT01295944 2025-08-05

Carboplatin and Bevacizumab for Recurrent Ependymoma

35 enrolled 17 charts

Brain Neoplasms, Ependymoma, Neoplasms, Neurologic Manifestations, Spinal Cord Neoplasms

NCT03890952 2025-07-24

Translational Study of Nivolumab in Combination With Bevacizumab for Recurrent Glioblastoma

40 enrolled

Brain Neoplasms

NCT04410367 2025-07-20

PURSUE

23 enrolled 10 charts

Brain Neoplasms, Disease

NCT02986178 2025-07-11

Lerapolturev in Recurrent Malignant Glioma

121 enrolled 15 charts

Brain Neoplasms, Glioblastoma, Glioma, Recurrence

NCT03173950 2025-06-29

Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers

133 enrolled

Brain Neoplasms, Ependymoma, Medulloblastoma, Meningioma, Pinealoma, Spinal Cord Neoplasms, Choroid Plexus Neoplasms

NCT04420598 2025-06-24

DEBBRAH

41 enrolled 32 charts

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Meningeal Carcinomatosis

NCT04743310 2025-06-13

Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System

50 enrolled

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Neuroma, Acoustic, Pinealoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT04479241 2025-06-05

LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma

25 enrolled 12 charts

Brain Neoplasms, Glioblastoma

NCT01288235 2025-06-03

Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation

100 enrolled 11 charts

Astrocytoma, Brain Neoplasms, Ependymoma, Ganglioglioma

NCT03898908 2025-05-21

EBRAIN-MEL

48 enrolled 24 charts

CNSDermatologic

Brain Neoplasms, Melanoma, Neoplasm Metastasis

NCT02595905 2025-05-16

Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases

344 enrolled

Brain Neoplasms, Breast Neoplasms, Triple Negative Breast Neoplasms

NCT04452084 2025-03-20

Phase 2 Trial in Multiple Brain Metastases Outcomes With HA-SIB-WBRT

42 enrolled

Brain Neoplasms

NCT01894061 2025-02-17

NovoTTF-100A With Bevacizumab (Avastin) in Patients With Recurrent Glioblastoma

25 enrolled 16 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT04233021 2025-02-03

ORBITAL

57 enrolled

Brain Neoplasms, Meningeal Carcinomatosis

NCT04824079 2025-01-22

Keynatinib in Treated Patients With NSCLC and Brain Metastases

16 enrolled

Brain Neoplasms

NCT05146219 2024-12-30

Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation

29 enrolled

Brain Neoplasms, Meningeal Carcinomatosis

NCT04946019 2024-12-12

MR-Linac Guided Adaptive FSRT for Brain Metastases From Non-small Cell Lung Cancer

55 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT01817751 2024-07-17

Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma

47 enrolled 13 charts

Brain Neoplasms, Glioblastoma, Glioma, Neurologic Manifestations

NCT01244737 2024-07-11

FLT-PET Imaging of Brain Tumors in Children

50 enrolled 11 charts

Brain Neoplasms

NCT02978404 2024-06-28

Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases

CNSDermatologicGenitourinaryThoracic

26 enrolled

Clear-cell metastatic renal cell carcinoma, Brain Neoplasms, Melanoma, Small Cell Lung Carcinoma

NCT02014844 2024-05-29

Phase 2 Study to Investigate the Efficacy and Safety of Aldoxorubicin in Subjects With Glioblastoma

28 enrolled 10 charts

Brain Neoplasms, Glioblastoma

NCT01472731 2024-05-06

Safety and Imaging Study of GC1008 in Glioma

12 enrolled

Brain Neoplasms

NCT03257631 2024-04-16

A Study of Pomalidomide Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors

53 enrolled 18 charts

Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Central Nervous System Neoplasms

NCT00445965 2024-04-04

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

CNSDermatologicGynecologicOther solid neoplasmSarcomaThoracic

78 enrolled 11 charts

Familial ependymoma, Uveal Melanoma, Astrocytoma, Brain Neoplasms, Chondrosarcoma, Ependymoma, Glioblastoma, Glioma, Lung Neoplasms, Medulloblastoma, Melanoma, Neoplasm Metastasis, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Glioma, Subependymal, Gliosarcoma, Rhabdoid Tumor, Optic Nerve Glioma, Small Cell Lung Carcinoma, Desmoplastic Small Round Cell Tumor

NCT03925246 2024-04-02

REVOLUMAB

43 enrolled

Brain Neoplasms, Glioma

NCT06289023 2024-03-01

HA-WBRT-SIB for Brain Metastasis of Lung Cancer

40 enrolled

Brain Neoplasms, Lung Neoplasms

NCT02073968 2024-01-25

PAINT

35 enrolled 13 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT01854554 2024-01-02

Glioblastoma Multiforme (GBM) Proton vs. Intensity Modulated Radiotherapy (IMRT)

90 enrolled 11 charts

Brain Neoplasms, Glioblastoma

NCT00002965 2023-12-22

Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Meningiomas

16 enrolled

Brain Neoplasms, Central Nervous System Neoplasms

NCT01622868 2023-10-17

Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer

143 enrolled 24 charts

Brain Neoplasms, Breast Neoplasms

NCT01508221 2023-09-14

Evaluation of the Use of Trental and Vitamin E For Prophylaxis of Radiation Necrosis

31 enrolled 8 charts

Brain Neoplasms

NCT00895622 2023-09-08

Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma

244 enrolled 15 charts

Brain Neoplasms, Meningioma, Central Nervous System Neoplasms

NCT04345146 2023-08-28

Bevacizumab Combined With Fractionated Stereotactic Radiotherapy for 1 to 10 Brain Metastases From NSCLC

100 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT02614794 2023-08-14

HER2CLIMB

612 enrolled 30 charts 2 FDA

Brain Neoplasms, Breast Neoplasms

NCT03520842 2023-08-01

Regorafenib and Methotrexate in Treating Participants With Recurrent or Metastatic KRAS Mutated Non-Small Cell Lung Cancer

22 enrolled 20 charts