Clinical Trials

Breast Neoplasms

NCT04300790 2025-07-29

METALLICA

69 enrolled

BreastEndocrine

Breast Neoplasms, Hyperglycemia, Neoplasm Metastasis, Multiple Endocrine Neoplasia Type 1

NCT02431676 2024-08-28

SPIRIT

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

121 enrolled 12 charts

Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT00984490 2024-02-01

Metformin Hydrochloride in Treating Women With Stage I or Stage II Breast Cancer That Can Be Removed By Surgery

Phase NA Terminated

5 enrolled 4 charts

Breast Neoplasms

NCT01101438 2023-09-13

A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer

Phase 3 Completed

3,649 enrolled 17 charts

Phase EARLY_PHASE1 Completed

Breast Neoplasms, Breast Neoplasms, Male

NCT01980823 2023-08-30

Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer

23 enrolled

Breast Neoplasms

NCT04741204 2023-07-06

METBC

Phase 4 Withdrawn

Breast Neoplasms, Insulin Resistance, Racism

NCT05840068 2023-05-03

IGF Level in Breast Cancer Patients Treated With Metformin

Phase 4 Completed

107 enrolled

Breast Neoplasms

NCT05351021 2023-03-09

Efficacy of Metformin as Preventive Treatment in Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients

76 enrolled

Breast Neoplasms, Peripheral Nervous System Diseases

NCT02874430 2022-12-15

Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer

27 enrolled

Breast Neoplasms

NCT00930579 2022-10-20

Pre-Surgical Study: Effect of Metformin on Breast Cancer Proliferation

35 enrolled 5 charts

Breast Neoplasms

NCT02278965 2022-08-17

Metformin and Omega-3 Fatty Acids in Woman With a History of Early Stage Breast Cancer

19 enrolled

BreastCNSGastrointestinalGynecologic

Breast Carcinoma In Situ, Breast Neoplasms

NCT02201381 2022-07-18

METRICS

Phase 3 Withdrawn

Brain Neoplasms, Breast Neoplasms, Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Triple Negative Breast Neoplasms

NCT04143282 2021-12-07

Evaluation of the Effect of Metformin on Metastatic Breast Cancer as Adjuvant Treatment

250 enrolled

Breast Neoplasms

NCT05053841 2021-09-23

Implication of Metformin Plus Aromatase Inhibitor in Obese Postmenopausal Breast Cancer Women

45 enrolled

Breast Neoplasms

NCT01310231 2021-04-14

A Trial of Standard Chemotherapy With Metformin (vs Placebo) in Women With Metastatic Breast Cancer

40 enrolled 27 charts

Breast Neoplasms

NCT04559308 2020-09-22

The Effect of Metformin on Breast Cancer Patients

80 enrolled

Breast Neoplasms

NCT01627067 2020-06-19

Exemestane-RAD001-Metformin

Phase 2 Terminated

23 enrolled 7 charts

Breast Neoplasms

NCT04387630 2020-06-11

Neoadjuvant Chemotherapy With or Without Metformin in Early Breast Cancer.

Phase 2/3 Unknown

120 enrolled

Breast Neoplasms

NCT01302379 2020-06-05

Reach for Health Study: Obesity-related Mechanisms and Mortality in Breast Cancer Survivors

Phase NA Completed

333 enrolled 17 charts

BreastOther

Breast Neoplasms, Obesity, Weight Loss

NCT04001725 2019-11-13

OPTIMAL

BreastCNSDermatologicThoracic

110 enrolled

Brain Neoplasms, Breast Neoplasms, Diabetes Mellitus, Lung Neoplasms, Melanoma, Neoplasms

NCT02506777 2019-09-04

MBC1

96 enrolled

Breast Neoplasms

NCT02506790 2019-09-04

Neoadjuvant Toremifene With Melatonin or Metformin in Locally Advanced Breast Cancer

96 enrolled

Phase EARLY_PHASE1 Completed

Breast Neoplasms

NCT01793948 2018-03-30

Metformin Hydrochloride vs. Placebo in Overweight or Obese Patients at Elevated Risk for Breast Cancer

24 enrolled

BreastOther

Breast Neoplasms, Obesity

NCT01650506 2017-08-30

Study of Erlotinib and Metformin in Triple Negative Breast Cancer

8 enrolled

Breast Neoplasms

NCT02360059 2017-08-17

Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer

Phase 2 Terminated

1 enrolled 3 charts

Breast Neoplasms

NCT00933309 2016-02-19

The Impact of Obesity and Obesity Treatments on Breast Cancer

25 enrolled

BreastOther

Breast Neoplasms, Obesity

NCT01885013 2016-01-01

MYME

126 enrolled

Breast Neoplasms

NCT01286233 2015-09-09

Study of Biomarkers Associated With Fatigue in Patients With Early-Stage Breast Cancer Treated With Metformin or Placebo on NCIC-CTG-MA.32

Unknown

394 enrolled

Breast Neoplasms, Depression, Fatigue, Sleep Wake Disorders

NCT00909506 2015-07-29

Efficacy and Safety of Adjuvant Metformin for Operable Breast Cancer Patients

105 enrolled

Breast Neoplasms

NCT01266486 2014-07-02

Effect of Metformin on Breast Cancer Metabolism

41 enrolled

Breast Neoplasms

NCT01477060 2014-02-20

Modulation of Response to Hormonal Therapy With Lapatinib and/or Metformin in Patients With Metastatic Breast Cancer

Phase 2 Terminated

32 enrolled

Breast Neoplasms

NCT01666171 2013-07-10

Studying Changes in Breast Density in Patients With Early-Stage Breast Cancer Treated With Metformin Hydrochloride or Placebo on CAN-NCIC-MA.32

Unknown

458 enrolled

Breast Neoplasms

NCT00659568 2013-05-30

Metformin and Temsirolimus in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma

BreastDermatologicGenitourinaryGynecologicLymphoidOther hematologic neoplasmThoracic

28 enrolled

Breast Neoplasms, Burkitt Lymphoma, Carcinoma, Renal Cell, Hodgkin Disease, Immunoblastic Lymphadenopathy, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Endometrial Neoplasms, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Small Cell Lung Carcinoma

NCT00897884 2012-01-19

Clinical and Biologic Effects of Metformin in Early Stage Breast Cancer

Phase NA Completed

39 enrolled