Clinical Trials

294 enrolled

Biliary Tract Neoplasms, Carcinoma, Hepatocellular

NCT02519348 2026-02-17

A Study of Durvalumab or Tremelimumab Monotherapy, or Durvalumab in Combination With Tremelimumab or Bevacizumab in Advanced Hepatocellular Carcinoma

433 enrolled 26 charts

Carcinoma, Hepatocellular

NCT03463876 2026-02-17

A Trial of SHR-1210 (an Anti-PD-1 Inhibitor) in Combination With Apatinib in Patients With Advanced HCC(RESCUE)

190 enrolled 15 charts

Carcinoma, Hepatocellular

NCT06953089 2026-02-06

DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors

DermatologicGastrointestinalGynecologicHead & NeckThoracic

492 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular, Melanoma, Ovarian Neoplasms

NCT06679985 2026-02-05

A Trial of Casdozokitug in Combination With Toripalimab Plus Bevacizumab in Participants With Unresectable and/or Locally Advanced or Metastatic Hepatocellular Carcinoma

72 enrolled

Carcinoma, Hepatocellular, Liver Neoplasms

NCT05641896 2026-01-22

18F-FAPI-74 GI

109 enrolled

Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT06040099 2026-01-20

EMERALD-Y90

56 enrolled

Carcinoma, Hepatocellular, Liver Neoplasms

NCT03228667 2026-01-14

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

40 enrolled

Turcot syndrome, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Melanoma, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Microsatellite Instability, Small Cell Lung Carcinoma

NCT07327034 2026-01-08

ABSK-011+BSC vs. Placebo+BSC in Previously Treated Advanced HCC With FGF19 Overexpression

141 enrolled

Carcinoma, Hepatocellular

NCT07081633 2025-12-30

TREMENDOUS-2

114 enrolled

Carcinoma, Hepatocellular

NCT07310173 2025-12-30

Phase IIb Study of AST-3424 in Patients With AKR1C3-high Expressing Advanced Hepatocellular Carcinoma

75 enrolled

Carcinoma, Hepatocellular

NCT05257590 2025-12-17

CVM-1118 in Combination With Nivolumab for Unresectable Advanced Hepatocellular Carcinoma

95 enrolled

Carcinoma, Hepatocellular, Neoplasms

NCT05879822 2025-12-17

A Study to Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor Naive

DermatologicGastrointestinalGenitourinaryThoracic

73 enrolled

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Melanoma

NCT05733598 2025-12-15

Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC

60 enrolled

Biliary Tract Neoplasms, Carcinoma, Hepatocellular

NCT07239986 2025-11-20

A Phase 2 Study of BB102 in Patients With Hepatocellular Carcinoma

60 enrolled

Carcinoma, Hepatocellular

NCT05256381 2025-11-17

A Study of SOT101 in Combination With Pembrolizumab to Evaluate the Efficacy and Safety in Patients With Selected Advanced Solid Tumors

GastrointestinalGynecologicThoracic

166 enrolled 43 charts

Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular, Ovarian Neoplasms, Colorectal Neoplasms

NCT07219459 2025-10-21

GDFATHERHCC01

104 enrolled

Carcinoma, Hepatocellular

NCT07209813 2025-10-07

GKL-006 Combined With TACE in Treatment of Unresectable Hepatocellular Carcinoma

48 enrolled

Carcinoma, Hepatocellular

NCT05104567 2025-09-24

A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)

138 enrolled 32 charts

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Carcinoma, Hepatocellular, Stomach Neoplasms, Colorectal Neoplasms

NCT05007106 2025-08-14

KEYVIBE-005

BreastGastrointestinalGenitourinaryGynecologicHead & Neck

613 enrolled

Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Ovarian Neoplasms, Stomach Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma, Triple Negative Breast Neoplasms

NCT05822752 2025-08-14

LIVIGNO-1

130 enrolled

Carcinoma, Hepatocellular, Neoplasms

NCT05563272 2025-07-10

STARBURST

CNSGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

11 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Nasopharyngeal Carcinoma, Mesothelioma, Malignant, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Carcinoma, Hepatocellular, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma, Small Cell Lung Carcinoma

NCT06984718 2025-05-22

A Phase II Study of AK104 Combination With Lenvatinib Versus Lenvatinib for Second-line HCC

120 enrolled

Carcinoma, Hepatocellular

NCT04696055 2025-05-13

Regorafenib Plus Pembrolizumab in Patients With Advanced or Spreading Liver Cancer Who Have Been Previously Treated With PD-1/PD-L1 Immune Checkpoint Inhibitors

95 enrolled 14 charts

Carcinoma, Hepatocellular, Liver Neoplasms

NCT04000737 2025-04-13

YIV-906 (Formerly PHY906/KD018) With Sorafenib in HBV(+) Hepatocellular Carcinoma (HCC)

62 enrolled

Hepatitis B, Carcinoma, Hepatocellular

NCT03916627 2025-04-11

Neoadjuvant Cemiplimab for the Treatment of Resectable NSCLC, HCC, and HNSCC in Adult Patients

GastrointestinalHead & NeckThoracic

65 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular

NCT04629339 2025-03-13

Study of INCB086550 in Select Solid Tumors

DermatologicGastrointestinalGenitourinaryThoracic

16 enrolled 17 charts

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Melanoma, Neoplasm Metastasis

NCT05864105 2025-03-12

PM8002 in Combination With Chemotherapy as First Line Therapy in Hepatocellular Carcinoma

35 enrolled

Carcinoma, Hepatocellular

NCT04401800 2025-03-10

Preliminary Antitumor Activity, Safety and Tolerability of Tislelizumab in Combination With Lenvatinib for Hepatocellular Carcinoma

64 enrolled 23 charts

Carcinoma, Hepatocellular

NCT05195294 2025-03-10

Study of HBV-TCR T Cells (LioCyx-M) as Monotherapy or as Combination With Lenvatinib for HBV-related HCC

55 enrolled

Hepatitis B, Carcinoma, Hepatocellular

NCT06742892 2025-03-10

A Phase II Clinical Study to Evaluate HLX43 in Patients With Locally Advanced or Metastatic HCC Failed or Intolerance to Standard Therapy

90 enrolled

Carcinoma, Hepatocellular

NCT04710641 2025-03-06

OUTREACH2

8 enrolled

Hepatitis B, Hepatitis C, Carcinoma, Hepatocellular

NCT05304481 2025-03-06

Efficacy and Safety of Activated T Lymphocytes (ATL) in Hepatocellular Carcinoma

95 enrolled

Carcinoma, Hepatocellular, Neoplasms

NCT05653427 2025-01-13

A Study of Amivantamab Monotherapy in Participants With Previously Treated Advanced Hepatocellular Carcinoma

18 enrolled 20 charts

Carcinoma, Hepatocellular

NCT06558227 2024-12-16

Study of ZG005 Combined With Bevacizumab Versus Sintilimab Combined With Bevacizumab in Advanced Hepatocellular Carcinoma

90 enrolled

Carcinoma, Hepatocellular

NCT06724263 2024-12-09

A Multicenter, Open-label Phase IIa Clinical Study to Evaluate the Efficacy and Safety of B1962 Injection in the Treatment of Advanced Malignant Solid Tumors

BreastGastrointestinalGynecologicThoracic

120 enrolled

Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Colorectal Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT03145558 2024-11-22

TATE

6 enrolled

Carcinoma, Hepatocellular

NCT03606590 2024-11-14

Effect of Tumor Treating Fields (TTFields, 150kHz) Concomitant with Sorafenib for Advanced Hepatocellular Carcinoma (HCC) (HEPANOVA)

25 enrolled

Carcinoma, Hepatocellular

NCT03419897 2024-10-26

Study of BGB-A317 in Participants With Previously Treated Unresectable HCC

249 enrolled 24 charts

Carcinoma, Hepatocellular

NCT00687596 2024-09-19

Study of TAC-101 as Second Line Treatment in Patients With Advanced Hepatocellular Carcinoma Who Received Sorafenib as First Line Therapy

52 enrolled 20 charts

Carcinoma, Hepatocellular

NCT00756782 2024-09-04

A Study of TAC-101 in Combination With TACE Versus TACE Alone in Asian Patients With Advanced Hepatocellular Carcinoma

Phase 2 Withdrawn

Carcinoma, Hepatocellular

NCT02702414 2024-09-04

KEYNOTE-224

156 enrolled 17 charts 1 FDA

Parkinson Disease 4, Autosomal Dominant Lewy Body, Carcinoma, Hepatocellular

NCT04172571 2024-05-30

A Study of the Combination of Anti-PD-1 AK105 and Anlotinib in First-line Hepatocellular Carcinoma (HCC)

31 enrolled

Carcinoma, Hepatocellular

NCT00940225 2024-04-25

Study of Cabozantinib (XL184) in Adults With Advanced Malignancies

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

730 enrolled 25 charts

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular, Melanoma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Small Cell Lung Carcinoma

NCT04728321 2024-04-25

A Study of Anti-PD-1/CTLA-4 Bispecific AK104 Alone or in Combination With Lenvatinib in Advanced Hepatocellular Carcinoma

32 enrolled