Clinical Trials

29 enrolled

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT03174275 2026-02-23

Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

39 enrolled 8 charts

GastrointestinalHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Esophageal Neoplasms, Laryngeal Neoplasms, Lip Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07214987 2026-01-30

PDT For Induction Therapy For Head And Neck Cancer

Phase 2 Not yet recruiting

26 enrolled

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT05366166 2026-01-28

Pembrolizumab Plus Olaparib in LA-HNSCC

45 enrolled

Phase 1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT06236425 2026-01-08

TBio-4101 and Pembro wi/ or w/o Chemo in Recurrent/Metastatic HNSCC

7 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT05027633 2025-11-19

Immunotherapy With Chemotherapy and Chemoradiation for Advanced Squamous Cancer of Nasal Cavity / Paranasal Sinuses (I-NAPA)

Phase 2 Active not recruiting

35 enrolled

Tumor-Agnostic

Carcinoma, Squamous Cell

NCT02994069 2025-10-14

Cisplatin + Radiation in SCCHN and Correlation With Oxidative Stress Markers

80 enrolled 11 charts

Carcinoma, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT02586207 2025-10-07

Pembrolizumab in Combination With CRT for LA-SCCHN

59 enrolled 9 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Diseases, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT06940180 2025-06-26

Toripalimab With Chemotherapy for Sinus Cancer

20 enrolled

Sinonasal undifferentiated carcinoma, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Paranasal Sinus Neoplasms

NCT05388773 2025-06-19

Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

150 enrolled

Carcinoma, Squamous Cell, DNA Virus Infections, Head and Neck Neoplasms, Stomatognathic Diseases, Neoplasms, Glandular and Epithelial, Oropharyngeal Neoplasms, Otorhinolaryngologic Diseases, Otorhinolaryngologic Neoplasms, Papilloma, Pharyngeal Diseases, Pharyngeal Neoplasms, Tumor Virus Infections, Papillomavirus Infections

NCT03274414 2025-05-16

A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages

3 enrolled 4 charts

CNS

Adenocarcinoma, Carcinoma, Squamous Cell, Carcinoma, Adenoid Cystic, Paranasal Sinus Neoplasms, Esthesioneuroblastoma, Olfactory

NCT03944915 2025-05-11

DEPEND

35 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT04595981 2025-04-27

Chemo-embolization for Head and Neck Cancer

Phase 2 Withdrawn

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT05608369 2025-04-04

HPV

Phase 2 Withdrawn

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT02128906 2025-03-26

Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design

120 enrolled

Carcinoma, Squamous Cell, Laryngeal Diseases

NCT05784012 2025-03-13

RADIAN

Phase 1/2 Recruiting

34 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT02281955 2025-01-07

De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study

115 enrolled 18 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT05966194 2024-11-15

KEVLARx

216 enrolled

Head & NeckOther

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Stomatitis, Mucositis

NCT01530997 2024-11-13

De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca

45 enrolled 22 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT02777385 2024-08-01

Pembrolizumab in Combination With Cisplatin and Intensity Modulated Radiotherapy (IMRT) in Head and Neck Cancer

80 enrolled 25 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT03641547 2024-07-18

CHARIOT

36 enrolled 24 charts

Phase 1 Active not recruiting

Adenocarcinoma Of Esophagus, Carcinoma, Squamous Cell, Esophageal Neoplasms

NCT02308072 2024-05-08

ORCA-2

70 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT03077243 2024-05-02

P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC

195 enrolled 19 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT05783921 2023-07-28

A Clinical Trial of TQB2618 Injection Combined With Penpulimab Injection and Chemotherapy Versus Penpulimab Injection Combined With Chemotherapy in First-line Treatment of Relapsed/Metastatic Head and Neck Squamous Cell Carcinoma

Phase 1/2 Unknown

60 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT02158234 2023-01-19

Stereotactic Body Radiotherapy and Concurrent Cisplatin for Re-Irradiation of Unresectable, Recurrent Squamous Cell Carcinomas of Head and Neck

20 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases

NCT01088802 2022-11-08

Treatment De-Intensification for Squamous Cell Carcinoma of the Oropharynx

60 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT00573131 2022-06-22

Efficacy and Safety of OncoGel™ Added to Chemotherapy and Radiation Before Surgery in Subjects With Esophageal Cancer

137 enrolled 9 charts

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Esophageal Neoplasms, Neoplasms

NCT03067610 2022-03-17

INFIELD

72 enrolled 14 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Pharyngeal Neoplasms

NCT04922450 2021-06-10

Clinical Study of Camrelizumab in Combination With Neoadjuvant Chemotherapy for Operable Locally Advanced Head and Neck Squamous Cell Carcinoma

53 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT02394652 2021-04-21

The Potential for Metformin to Improve Tumor Oxygenation in Locally Advanced Cervix Cancer: A Phase II Randomized Trial

16 enrolled

Gynecologic

Adenocarcinoma, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, Carcinoma, Adenosquamous

NCT03791905 2021-03-23

PET Imaging-guided Chemoradiotherapy in Esophageal Squamous Cell Carcinoma

216 enrolled

Esophageal Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Esophageal Neoplasms

NCT00833261 2020-08-21

Nab-Paclitaxel, Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer

37 enrolled 6 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Tongue Neoplasms, Carcinoma, Verrucous

NCT01133678 2020-05-08

Study in Locally Advanced Squamous Cell Carcinoma of Head and Neck

50 enrolled 9 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT01445405 2019-12-17

Radiation Therapy and Bortezomib and Cetuximab With or Without Cisplatin to Treat Head and Neck Cancer

3 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Pharyngeal Neoplasms

NCT01631357 2019-11-05

CIK

Phase 2/3 Completed

96 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell

NCT02633800 2019-01-07

Patritumab With Cetuximab and a Platinum Agent for Squamous Cell Carcinoma (Cancer) of the Head and Neck (SCCHN )

87 enrolled 13 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasms by Site

NCT00500760 2018-10-17

Study of Addition of Panitumumab to Chemoradiation Therapy in Patients With Locally Advanced Head and Neck Cancer

153 enrolled 18 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT03579004 2018-07-06

Neoadjuvant Chemotherapy Followed by Preoperative Chemoradiation in Resectable Squamous-cell Esophageal Cancer

48 enrolled

Esophageal Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Esophageal Neoplasms

NCT02035527 2018-05-24

Sorafenib Tosylate, Cisplatin, and Docetaxel in Treating Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

3 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Salivary Gland Neoplasms, Tongue Neoplasms

NCT02298595 2017-11-13

Cetuximab, Cisplatin and BYL719 for HPV-Associated Oropharyngeal Squamous Cell Carcinoma

Phase 1/2 Withdrawn

Carcinoma, Carcinoma, Squamous Cell, Oropharyngeal Neoplasms

NCT00400205 2017-11-06

Study of Induction Docetaxel, Cisplatin and 5-Fluorouracil

14 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Mouth Neoplasms

NCT00547157 2017-03-15

Radiotherapy Plus Panitumumab Compared to Chemoradiotherapy With Unresected, Locally Advanced Squamous Cell Carcinoma of the Head and Neck

152 enrolled 18 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasms

NCT02088515 2017-03-03

Nedaplatin (Jiebaishu®) Combined With Docetaxel for Advanced Lung Squamous Cell Carcinoma

Phase 4 Completed

290 enrolled

Tumor-Agnostic

Carcinoma, Squamous Cell

NCT02985255 2016-12-07

Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue

30 enrolled

Carcinoma, Squamous Cell, Tongue Neoplasms

NCT00190554 2016-09-22

A Trial of Chemotherapy Before and After Surgery for Stage II,III Esophageal Squamous Cell Carcinoma

Phase 3 Terminated

330 enrolled

Esophageal Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Esophageal Neoplasms

NCT02891083 2016-09-07

Adjuvant Therapies or Surgery Alone for High Risk pN0 Esophageal Cancer

Phase 3 Unknown

486 enrolled

Carcinoma, Squamous Cell, Esophageal Neoplasms, Lymphatic Metastasis

NCT00450138 2016-08-29

Open Label, Phase I ZD6474 Head and Neck Cancer Study

48 enrolled