Completed × NIH × Central Nervous System Neoplasms × Clear all Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors
Completed
76 enrolled
Rare CNS Tumors Outcomes &Risk
Completed
326 enrolled
Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab
Phase 2 Completed
35 enrolled 13 charts
Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)
Phase 2 Completed
21 enrolled 11 charts
Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)
Phase 2 Completed
20 enrolled 12 charts
Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)
Phase 2 Completed
18 enrolled 12 charts
Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)
Phase 2 Completed
4 enrolled 12 charts
Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)
Phase 2 Completed
6 enrolled 12 charts
Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors
Phase 1 Completed
Cabozantinib S-Malate in Treating Younger Patients With Recurrent or Refractory Solid Tumors
Phase 1 Completed
41 enrolled 20 charts
Stereotactic Radiosurgery in Treating Patients With Brain Tumors
Phase 1 Completed
Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors
Phase 1 Completed
21 enrolled 15 charts
Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors
Phase 1/2 Completed
76 enrolled 25 charts
Pomalidomide in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors
Phase 1 Completed
29 enrolled
O6-Benzylguanine and Temozolomide in Treating Young Patients With Recurrent or Progressive Gliomas or Brain Stem Tumors
Phase 2 Completed
41 enrolled 9 charts
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors
Phase 2 Completed
108 enrolled 14 charts
Talazoparib and Temozolomide in Treating Younger Patients With Refractory or Recurrent Malignancies
Phase 1/2 Completed
40 enrolled 32 charts
Natural History of Patients With Brain and Spinal Cord Tumors
Completed
3,050 enrolled
Trebananib in Treating Younger Patients With Relapsed or Refractory Solid Tumors, Including Central Nervous System Tumors
Phase 1 Completed
37 enrolled
Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors
Phase 1 Completed
3,000 enrolled
CC-5013 in Treating Patients With Recurrent Glioma
Phase 1 Completed
CC-8490 in Treating Patients With Recurrent or Refractory High-Grade Gliomas
Phase 1 Completed
Radiation Therapy in Treating Patients With Glioblastoma
Phase 1 Completed
34 enrolled
Chemotherapy Followed by Radiation Therapy in Treating Patients With Malignant Glioma
Phase 1 Completed
Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors
Phase 1 Completed
Lapatinib in Treating Patients With Recurrent Glioblastoma Multiforme
Phase 1/2 Completed
24 enrolled
Combination Chemotherapy and Radiation Therapy in Treating Younger Patients Who Are Undergoing an Autologous Stem Cell Transplant for Newly Diagnosed Gliomas
Phase NA Completed
Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma
Phase 3 Completed
500 enrolled
Biological Therapy in Treating Patients With Glioblastoma Multiforme
Phase 2 Completed
40 enrolled
Surgery Plus Radiation Therapy With or Without Chemotherapy in Treating Children With Primitive Neuroectodermal Tumors of the CNS
Phase 3 Completed
230 enrolled
Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain
Phase 3 Completed
500 enrolled
Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma
Phase 2 Completed
65 enrolled
Lobradimil and Carboplatin in Treating Children With Brain Tumors
Phase 2 Completed
Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma
Phase 3 Completed
Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors
Phase 2 Completed
50 enrolled
Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma
Phase NA Completed
120 enrolled
Gallium Nitrate in Treating Children With Brain Tumor, Neuroblastoma, Rhabdomyosarcoma, Non-Hodgkin's Lymphoma, or Refractory Solid Tumors
Phase 1 Completed
3 enrolled
Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma
Phase 2 Completed
NBI-3001 Followed by Surgery in Treating Patients With Recurrent Glioblastoma Multiforme
Phase 2 Completed
Phenylacetate in Treating Children With Recurrent or Progressive Brain Tumors
Phase 2 Completed
Motexafin Gadolinium With MRI-Guided Surgery in Treating Patients With High-Grade Gliomas
Phase 1 Completed
Internal Radiation Therapy Plus Carmustine Implants in Treating Patients With Recurrent or Refractory Malignant Glioma
Phase 1 Completed
Immunotoxin Therapy Before and After Surgery in Treating Patients With Recurrent Malignant Glioma
Phase 1 Completed
Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain
Phase 1/2 Completed
High-Dose Methotrexate in Treating Young Patients With Solid Tumors
Phase 1 Completed
36 enrolled
EMD 121974 in Treating Patients With Progressive or Recurrent Glioma
Phase 1/2 Completed
Immunotoxin Therapy in Treating Patients With Malignant Glioma
Phase 1/2 Completed
Chemotherapy in Treating Patients With Progressive or Recurrent Brain Tumors
Phase 1/2 Completed
Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors
Phase 2 Completed
29 enrolled
Pharmacologic Study of Methotrexate in Patients Undergoing Stereotactic Biopsy for Recurrent High-Grade Glioma
Phase NA Completed
12 enrolled