Clinical Trials Browser

Phase 1 × Terminated × Cholangiocarcinoma × Clear all

Bile Duct Neoplasms, Neoplasm Metastasis, Cholangiocarcinoma

NCT05194072 2026-01-09

A Study of Felmetatug Vedotin/SGN-B7H4V in Advanced Solid Tumors

BreastGastrointestinalGynecologicThoracic

Carcinoma, Non-Small-Cell Lung, Carcinoma, Adenoid Cystic, Fallopian Tube Neoplasms, Gallbladder Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma, Triple Negative Breast Neoplasms

NCT06420349 2025-12-22

NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma

Phase 1 Terminated

7 enrolled

Gastrointestinal

Cholangiocarcinoma, Klatskin Tumor

NCT03144661 2025-10-21

An Open-Label Safety and Tolerability Study of INCB062079 in Subjects With Advanced Hepatocellular Carcinoma and Other Malignancies

Phase 1 Terminated

25 enrolled

GastrointestinalGynecologicHead & Neck

Acrocephalosyndactylia, Esophageal Neoplasms, Carcinoma, Hepatocellular, Nasopharyngeal Neoplasms, Ovarian Neoplasms, Cholangiocarcinoma

NCT06336148 2025-10-15

A Phase 1a/1b Study of ACTM-838 in Patients With Advanced Solid Tumors

Phase 1 Terminated

10 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Melanoma, Mesothelioma, Ovarian Neoplasms, Pancreatic Neoplasms, Sarcoma, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT04762602 2025-09-16

A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

Phase 1 Terminated

42 enrolled

CNSGastrointestinal

Glioma, Cholangiocarcinoma

NCT02784795 2025-08-21

A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors

Phase 1 Terminated

94 enrolled 28 charts

BreastGastrointestinalSarcoma

Breast Neoplasms, Colonic Neoplasms, Sarcoma, Cholangiocarcinoma

NCT05432193 2025-06-25

FAPi Radioligand OpeN-Label, Phase 1 Study to Evaluate Safety, Tolerability and DosImetry of [Lu-177]-PNT6555; A Dose Escalation Study for TReatment of Patients With Select Solid Tumors (FRONTIER)

Phase 1 Terminated

20 enrolled

DermatologicGastrointestinalHead & NeckSarcoma

Squamous Cell Carcinoma of Head and Neck, Esophageal Neoplasms, Melanoma, Sarcoma, Colorectal Neoplasms, Cholangiocarcinoma

NCT05242822 2025-05-07

A Study to Evaluate KIN-3248 in Participants With Advanced Tumors Harboring FGFR2 and//or FGFR3 Gene Alterations

Phase 1 Terminated

54 enrolled

GastrointestinalGenitourinary

Carcinoma, Transitional Cell, Cholangiocarcinoma

NCT05501912 2024-11-29

A Study of ABM-1310 in Patients With BRAF V600-Mutant Advanced Solid Tumors

Phase 1 Terminated

20 enrolled

DermatologicGastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Melanoma, Cholangiocarcinoma

NCT02714374 2024-08-06

GL-ONC1 Administered Intravenously Prior to Surgery to Patients With Solid Organ Cancers

Phase 1 Terminated

5 enrolled

DermatologicGastrointestinalOther solid neoplasmThoracic

Gallbladder Neoplasms, Melanoma, Mesothelioma, Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT04190628 2024-05-21

Safety and Tolerability of ABM-1310 in Patients With Advanced Solid Tumors

Phase 1 Terminated

53 enrolled

CNSDermatologicGastrointestinalGynecologicHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Glioblastoma, Melanoma, Ovarian Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT04088188 2024-05-06

Gemcitabine and Cisplatin With Ivosidenib or Pemigatinib for the Treatment of Unresectable or Metastatic Cholangiocarcinoma

Phase 1 Terminated

8 enrolled 14 charts

Gastrointestinal

Cholangiocarcinoma

NCT04304781 2022-11-22

Phase 1 In-vivo Biliary Study of KSP/QRH Heptapeptide Dimer

Phase 1 Terminated

12 enrolled

Gastrointestinal

Cholangiocarcinoma

NCT01525069 2022-08-10

Hepatic Arterial Infusion in Treating Patients With Locally Advanced, Non-Metastatic Cholangiocarcinoma

Phase 1 Terminated

27 enrolled

Gastrointestinal

Liver Neoplasms, Cholangiocarcinoma

NCT02908451 2021-07-13

A Study of AbGn-107 in Patients With Gastric, Colorectal, Pancreatic or Biliary Cancer

Phase 1 Terminated

39 enrolled

Gastrointestinal

Adenocarcinoma, Biliary Tract Neoplasms, Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT02757391 2020-10-30

CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors

Phase 1 Terminated

1 enrolled

Gastrointestinal

Esophageal Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT02012231 2020-10-19

Phase I/IIa Study to Evaluate the Safety, PK, PD, and Preliminary Efficacy of PLX8394 in Patients With Advanced Cancers.

Phase 1 Terminated

5 enrolled

DermatologicEndocrineGastrointestinalHead & NeckMyeloidOther hematologic neoplasmThoracic

Carcinoma, Non-Small-Cell Lung, Leukemia, Hairy Cell, Melanoma, Thyroid Neoplasms, Colorectal Neoplasms, Histiocytosis, Cholangiocarcinoma, Thyroid Carcinoma, Anaplastic

NCT03267940 2020-02-07

Study of PEGPH20 With Cisplatin (CIS) and Gemcitabine (GEM); PEGPH20 With Atezolizumab (ATEZO), CIS, and GEM; and CIS and GEM Alone in Participants With Previously Untreated, Unresectable, Locally Advanced, or Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder Adenocarcinoma

Phase 1 Terminated

85 enrolled 17 charts

Gastrointestinal

Cholangiocarcinoma

NCT00630890 2015-09-11

Cyberknife Radiosurgery Boost for Hilar Cholangiocarcinoma (Klatskin Tumor)

Phase 1 Terminated

11 enrolled

Gastrointestinal

Biliary Tract Neoplasms, Cholangiocarcinoma, Klatskin Tumor

NCT01434459 2015-05-04

Study of Gemcitabine With TheraSphere® (Yttrium-90)in Patients With Hepatic Tumors of Pancreatobiliary Origin

Phase 1 Terminated

9 enrolled

Gastrointestinal

Pancreatic Neoplasms, Cholangiocarcinoma

Clinical Trials

MAST

A Study of Felmetatug Vedotin/SGN-B7H4V in Advanced Solid Tumors

NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma

An Open-Label Safety and Tolerability Study of INCB062079 in Subjects With Advanced Hepatocellular Carcinoma and Other Malignancies

A Phase 1a/1b Study of ACTM-838 in Patients With Advanced Solid Tumors

A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors

FAPi Radioligand OpeN-Label, Phase 1 Study to Evaluate Safety, Tolerability and DosImetry of [Lu-177]-PNT6555; A Dose Escalation Study for TReatment of Patients With Select Solid Tumors (FRONTIER)

A Study to Evaluate KIN-3248 in Participants With Advanced Tumors Harboring FGFR2 and//or FGFR3 Gene Alterations

A Study of ABM-1310 in Patients With BRAF V600-Mutant Advanced Solid Tumors

GL-ONC1 Administered Intravenously Prior to Surgery to Patients With Solid Organ Cancers

Safety and Tolerability of ABM-1310 in Patients With Advanced Solid Tumors

Gemcitabine and Cisplatin With Ivosidenib or Pemigatinib for the Treatment of Unresectable or Metastatic Cholangiocarcinoma

Phase 1 In-vivo Biliary Study of KSP/QRH Heptapeptide Dimer

Hepatic Arterial Infusion in Treating Patients With Locally Advanced, Non-Metastatic Cholangiocarcinoma

A Study of AbGn-107 in Patients With Gastric, Colorectal, Pancreatic or Biliary Cancer

CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors

Phase I/IIa Study to Evaluate the Safety, PK, PD, and Preliminary Efficacy of PLX8394 in Patients With Advanced Cancers.

Cyberknife Radiosurgery Boost for Hilar Cholangiocarcinoma (Klatskin Tumor)

Study of Gemcitabine With TheraSphere® (Yttrium-90)in Patients With Hepatic Tumors of Pancreatobiliary Origin