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Phase 2 × Chordoma × Afatinib × Clear all

Phase

Status

Sponsor Class

Study Type

Interventional 1

Sponsor

Cancer Type

Conditions

Carcinoma, Non-Small-Cell Lung 18 Lung Neoplasms 6 Breast Neoplasms 6 Squamous Cell Carcinoma of Head and Neck 5 Head and Neck Neoplasms 5 Esophageal Squamous Cell Carcinoma 5 Neoplasms 4 Neoplasm Metastasis 4 Carcinoma, Squamous Cell 4 Stomach Neoplasms 2 Prostatic Neoplasms 2 Non-small-cell Lung Cancer With Somatic EGFR Mutations 2 Esophageal Neoplasms 2 Colorectal Neoplasms 2 Adenocarcinoma of Lung 2 Urologic Neoplasms 1 Urinary Bladder Neoplasms 1 Urethral Neoplasms 1 Ureteral Neoplasms 1 Triple Negative Breast Neoplasms 1 Squamous Cell Cancers of the Head and Neck 1 Solid Tumors 1 Small Cell Lung Carcinoma 1 Pathologic Complete Response 1 PFS 1 NSCLC Harboring NRG1 Fusion 1 Multiple Myeloma 1 Lymphoma 1 Gallbladder Neoplasms 1 Focus of Study Instead 1

Interventions

Nivolumab 3 palbociclib 2 Ipilimumab 2 Imatinib Mesylate 2 relatlimab 1 pembrolizumab 1 camrelizumab 1 apatinib 1 Specimen Handling 1 Radiotherapy 1 Radiation 1 Protons 1 Proton Therapy 1 Pemetrexed 1 Magnetic Resonance Spectroscopy 1 Immunoglobulin G 1 Disulfides 1 Dasatinib 1 Cetuximab 1 CTLA-4 Antigen 1 Afatinib 1

Date Range

30 days 90 days 1 year All

Options

Has results Has announcements

NCT03083678 2025-02-13

Afatinib in Locally Advanced and Metastatic Chordoma

Leiden University Medical Center

Phase 2 Completed

Chordoma

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