Clinical Trials Browser

Colonic Neoplasms

NCT03365882 2026-02-10

S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery

Phase 2 Completed

240 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT00556413 2026-02-05

Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

Phase 2 Completed

42 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04505553 2026-01-21

Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer

Phase 2 Completed

78 enrolled 14 charts

EndocrineGastrointestinalNET

Gastro-enteropancreatic neuroendocrine tumor, Anus Neoplasms, Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Adenoma, Islet Cell, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT02978612 2025-09-05

ACE

Phase 2 Completed

170 enrolled

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms

NCT03482362 2025-08-03

EORTC1616

Phase 2 Completed

1 enrolled

Gastrointestinal

Colonic Neoplasms

NCT05480306 2025-08-03

DeFianCe

Phase 2 Completed

188 enrolled

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms

NCT03442569 2025-07-01

PhII Trial Panitumumab, Nivolumab, Ipilimumab in Kras/Nras/BRAF Wild-type MSS Refractory mCRC

Phase 2 Completed

56 enrolled 13 charts

Gastrointestinal

Colonic Neoplasms

NCT05513742 2025-06-26

COMPANION-003

Phase 2 Completed

49 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02368886 2025-06-18

Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer

Phase 2 Completed

123 enrolled 21 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04625803 2025-06-17

Neoadjuvant Therapy for Locally Advanced Colon Cancer

Phase 2 Completed

64 enrolled 11 charts

Gastrointestinal

Colonic Neoplasms

NCT03642067 2025-06-15

Study of Nivolumab and Relatlimab in Patients With Microsatellite Stable (MSS) Advanced Colorectal Cancer

Phase 2 Completed

59 enrolled 11 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Spinocerebellar Degenerations, Colorectal Neoplasms

NCT06804876 2025-05-21

COMBO Endoscopy Oropharyngeal Airway in Sedated Gastrointestinal Endoscopy for Obese Patients

Phase 2 Completed

107 enrolled

Gastrointestinal

Hypoxia, Colonic Neoplasms, Esophageal Neoplasms, Stomach Neoplasms

NCT02138617 2025-05-18

Genotype-Directed Study Of Irinotecan Dosing In FOLFIRI + BevacizumabTreated Metastatic Colorectal Cancer

Phase 2 Completed

100 enrolled 13 charts

Gastrointestinal

Colonic Neoplasms

NCT00200200 2025-03-19

Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combination With Chemotherapy With/Without Bevacizumab for Hepatic Metastases From Colorectal Cancer

Phase 2 Completed

73 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT01652196 2025-02-05

Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer

Phase 2 Completed

56 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01814501 2025-02-05

Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab

Phase 2 Completed

16 enrolled 11 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT03565029 2024-12-27

NO-CUT

Phase 2 Completed

180 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT04534218 2024-12-20

REPROGRAM-01

Phase 2 Completed

49 enrolled

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis

NCT02431676 2024-08-28

SPIRIT

Phase 2 Completed

121 enrolled 12 charts

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT05662527 2024-08-13

RESET-C

Phase 2 Completed

85 enrolled

Gastrointestinal

Colonic Neoplasms

NCT06454071 2024-06-12

Immunologic Changes and Recovery-related Factors in Elderly Colon Cancer Patients

Phase 2 Completed

75 enrolled

Gastrointestinal

Colonic Neoplasms

NCT03360461 2024-05-08

EMI-137 in Laparoscopic Colonic Resections

Phase 2 Completed

10 enrolled

Gastrointestinal

Colonic Neoplasms, Lymphatic Metastasis

NCT00321828 2024-03-21

Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colon Cancer That Cannot Be Removed By Surgery

Phase 2 Completed

90 enrolled 6 charts

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms

NCT00407654 2024-03-04

VEGF Trap in Treating Patients With Previously Treated Metastatic Colorectal Cancer

Phase 2 Completed

75 enrolled 15 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT01763307 2024-02-29

EGFRI

Phase 2 Completed

18 enrolled

Gastrointestinal

Colonic Neoplasms

NCT03698461 2024-01-31

CLIMB

Phase 2 Completed

20 enrolled

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00019760 2023-10-31

Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Genetic Diseases, Inborn

NCT03854799 2023-10-19

AVANA

Phase 2 Completed

101 enrolled

Gastrointestinal

Colonic Neoplasms

NCT04312360 2023-09-07

MEFO

Phase 2 Completed

28 enrolled

Gastrointestinal

Colonic Neoplasms

NCT00098787 2023-07-05

Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer

Phase 2 Completed

247 enrolled 10 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01079780 2023-06-28

Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy

Phase 2 Completed

136 enrolled 13 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00002650 2023-06-22

High-Dose Folic Acid in Preventing Colorectal Cancer in Patients Who Have Had Polyps Surgically Removed

Phase 2 Completed

80 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00002997 2023-06-15

Cryosurgery in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00004860 2023-06-15

Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03428126 2023-06-15

Study of Durvalumab (MEDI4736) (Anti-PD-L1) and Trametinib (MEKi) in MSS Metastatic Colon Cancer

Phase 2 Completed

29 enrolled 9 charts

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms

NCT03801915 2023-03-21

Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers

Phase 2 Completed

10 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Pancreatic Neoplasms, Cholangiocarcinoma

NCT03493061 2023-02-15

A Study of Systemic Chemotherapy With CPT-11 Plus HAI (FUDR+L-OHP) in Patients With Initially Unresectable CRCLM

Phase 2 Completed

60 enrolled

Gastrointestinal

Colonic Neoplasms

NCT00819780 2022-12-06

PEAK: Panitumumab Plus mFOLFOX6 vs. Bevacizumab Plus mFOLFOX6 for First Line Treatment of Metastatic Colorectal Cancer (mCRC) Patients With Wild-Type Kirsten Rat Sarcoma-2 Virus (KRAS) Tumors

Phase 2 Completed

285 enrolled 31 charts

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00089635 2022-11-07

Panitumumab (ABX-EGF) Monotherapy in Patients With Metastatic Colorectal Cancer

Phase 2 Completed

203 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT03086538 2022-06-15

Pemetrexed Plus Tarceva as Salvage Treatment in EGFR Overexpressed Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy

Phase 2 Completed

29 enrolled

Gastrointestinal

Colonic Neoplasms

NCT00193219 2022-01-11

Bevacizumab and Cetuximab in Combination With FOLFOX6 in Patients With Metastatic Colorectal Cancer

Phase 2 Completed

36 enrolled 8 charts

Gastrointestinal

Colonic Neoplasms

NCT01535040 2021-09-28

Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking

Phase 2 Completed

130 enrolled 12 charts

BreastGastrointestinalGenitourinaryThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Tobacco Use Disorder, Colorectal Neoplasms

NCT00640081 2021-09-22

Combination Chemotherapy and Cetuximab as First-Line Therapy in Treating Patients With Advanced and/or Metastatic Colorectal Cancer

Phase 2 Completed

169 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01006369 2021-09-21

Hydroxychloroquine, Capecitabine, Oxaliplatin, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

Phase 2 Completed

38 enrolled 12 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00007943 2021-09-09

Gemcitabine in Treating Patients With Advanced Colorectal Cancer

Phase 2 Completed

15 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00361842 2021-07-02

Multicenter Study Of CPX-1 (Irinotecan HCl: Floxuridine) Liposome Injection In Patients With Advanced Colorectal Cancer

Phase 2 Completed

65 enrolled 10 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01902953 2021-06-23

Lymphoseek® as Lymphoid Tissue Targeting Agents in Colon Cancer(CNC)

Phase 2 Completed

16 enrolled 5 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT00066274 2021-03-02

Comparison of Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00104689 2021-02-21

Capecitabine and Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer

Phase 2 Completed

60 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

Clinical Trials

Palbociclib and Cetuximab in Metastatic Colorectal Cancer

S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery

Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer

ACE

EORTC1616

DeFianCe

PhII Trial Panitumumab, Nivolumab, Ipilimumab in Kras/Nras/BRAF Wild-type MSS Refractory mCRC

COMPANION-003

Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer

Neoadjuvant Therapy for Locally Advanced Colon Cancer

Study of Nivolumab and Relatlimab in Patients With Microsatellite Stable (MSS) Advanced Colorectal Cancer

COMBO Endoscopy Oropharyngeal Airway in Sedated Gastrointestinal Endoscopy for Obese Patients

Genotype-Directed Study Of Irinotecan Dosing In FOLFIRI + BevacizumabTreated Metastatic Colorectal Cancer

Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combination With Chemotherapy With/Without Bevacizumab for Hepatic Metastases From Colorectal Cancer

Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer

Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab

NO-CUT

REPROGRAM-01

SPIRIT

RESET-C

Immunologic Changes and Recovery-related Factors in Elderly Colon Cancer Patients

EMI-137 in Laparoscopic Colonic Resections

Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colon Cancer That Cannot Be Removed By Surgery

VEGF Trap in Treating Patients With Previously Treated Metastatic Colorectal Cancer

EGFRI

CLIMB

Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver

AVANA

MEFO

Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer

Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy

High-Dose Folic Acid in Preventing Colorectal Cancer in Patients Who Have Had Polyps Surgically Removed

Cryosurgery in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer

Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer

Study of Durvalumab (MEDI4736) (Anti-PD-L1) and Trametinib (MEKi) in MSS Metastatic Colon Cancer

Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers

A Study of Systemic Chemotherapy With CPT-11 Plus HAI (FUDR+L-OHP) in Patients With Initially Unresectable CRCLM

PEAK: Panitumumab Plus mFOLFOX6 vs. Bevacizumab Plus mFOLFOX6 for First Line Treatment of Metastatic Colorectal Cancer (mCRC) Patients With Wild-Type Kirsten Rat Sarcoma-2 Virus (KRAS) Tumors

Panitumumab (ABX-EGF) Monotherapy in Patients With Metastatic Colorectal Cancer

Pemetrexed Plus Tarceva as Salvage Treatment in EGFR Overexpressed Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy

Bevacizumab and Cetuximab in Combination With FOLFOX6 in Patients With Metastatic Colorectal Cancer

Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking

Combination Chemotherapy and Cetuximab as First-Line Therapy in Treating Patients With Advanced and/or Metastatic Colorectal Cancer

Hydroxychloroquine, Capecitabine, Oxaliplatin, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

Gemcitabine in Treating Patients With Advanced Colorectal Cancer

Multicenter Study Of CPX-1 (Irinotecan HCl: Floxuridine) Liposome Injection In Patients With Advanced Colorectal Cancer

Lymphoseek® as Lymphoid Tissue Targeting Agents in Colon Cancer(CNC)

Comparison of Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer

Capecitabine and Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer