Clinical Trials

Phase EARLY_PHASE1 Active not recruiting

30 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal

NCT06011772 2026-03-11

EGF-Depleting Therapy CIMAvax-EGF in Combination With Standard Therapy for RAS- and BRAF Wild-Type Metastatic Colorectal Cancer

2 enrolled

Colonic Neoplasms

NCT01918527 2026-03-10

Neoadjuvant Chemotherapy Versus Standard Treatment in Patients With Locally Advanced Colon Cancer

250 enrolled

Colonic Neoplasms

NCT05677048 2026-03-09

Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention

BreastGastrointestinalGynecologic

205 enrolled

Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Ovarian Neoplasms, Pancreatic Neoplasms, Uterine Neoplasms, Endometrial Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT03151564 2026-03-05

Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniques

146 enrolled

Colonic Neoplasms, Digestive System Diseases, Colorectal Neoplasms

NCT05722327 2026-03-04

Phase I Trial of Adagrasib (MRTX849) in Combination With Cetuximab and Irinotecan in Patients With Colorectal Cancer

24 enrolled

Colonic Neoplasms, Colorectal Neoplasms

NCT07448662 2026-03-04

COLBRAIN

700 enrolled

CNSGastrointestinal

Brain Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04068610 2026-03-02

COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC

61 enrolled 35 charts

Colonic Neoplasms

NCT05579340 2026-02-24

POET-mCRC

66 enrolled

Colonic Neoplasms

NCT03523546 2026-02-20

Oncology Episode Payment Model in Hawaii

BreastGastrointestinalThoracic

7 enrolled

Breast Neoplasms, Colonic Neoplasms, Lung Neoplasms

NCT04258813 2026-02-20

ONE TEAM

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

313 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Cardiovascular Diseases, Colonic Neoplasms, Diabetes Mellitus, Esophageal Neoplasms, Head and Neck Neoplasms, Hypercholesterolemia, Hypertension, Liver Neoplasms, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Endometrial Neoplasms

NCT01460589 2026-02-12

ECTX

303 enrolled

Colonic Neoplasms

NCT03426904 2026-02-11

Neoadjuvant FOLFOX Chemotherapy for Patients With Locally Advanced Colon Cancer

708 enrolled

Phase 2 Active not recruiting

Colonic Neoplasms

NCT04963283 2026-02-10

Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer

48 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02912559 2026-02-02

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

712 enrolled

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Repair-Deficiency Disorders

NCT06710847 2026-02-02

SYLVER

GastrointestinalGynecologic

14 enrolled

Turcot syndrome, Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT02432963 2026-01-28

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

BreastDermatologicGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

11 enrolled

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Carcinoma, Hepatocellular, Melanoma, Pancreatic Neoplasms, Rectal Neoplasms, Sarcoma, Triple Negative Breast Neoplasms

NCT05710406 2026-01-26

Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer

Phase 2/3 Active not recruiting

1 enrolled

Colonic Neoplasms

NCT04599140 2026-01-22

SX-682 and Nivolumab for the Treatment of RAS-Mutated, MSS Unresectable or Metastatic Colorectal Cancer, the STOPTRAFFIC-1 Trial

51 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05983133 2026-01-22

A Study of PF-08046052/SGN-EGFRd2 in Advanced Solid Tumors

GastrointestinalHead & NeckThoracic

65 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07342998 2026-01-15

Could Computerized Tomography be an Alternative to Colonoscopies for Screening for Colorectal Cancer?

600 enrolled

Phase EARLY_PHASE1 Active not recruiting

Colonic Neoplasms

NCT05108428 2026-01-08

Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma

20 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT03899792 2026-01-06

LIBRETTO-121

36 enrolled 13 charts 2 FDA

BreastCNSEndocrineGastrointestinalHead & NeckSarcomaThoracic

Thyroid Cancer, Papillary, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Site, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Central Nervous System Neoplasms, Myofibromatosis, Carcinoma, Medullary

NCT05544929 2026-01-06

A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

126 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Nasopharyngeal Carcinoma, Anus Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Intestinal Neoplasms, Kidney Neoplasms, Lung Neoplasms, Melanoma, Mesothelioma, Nasopharyngeal Neoplasms, Neoplasms, Ovarian Neoplasms, Rectal Neoplasms, Skin Neoplasms, Thymoma, Thymus Neoplasms, Colorectal Neoplasms, Adenocarcinoma, Clear Cell, Triple Negative Breast Neoplasms

NCT04708470 2025-12-31

A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers

GastrointestinalGenitourinaryGynecologicHead & Neck

55 enrolled

Anus Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT04616183 2025-12-23

LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer

46 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07205965 2025-12-19

The Effect of Acceptance and Commitment Approach-Based Psychoeducation in Cancer Survivors

32 enrolled

BreastGastrointestinal

Anxiety Disorders, Breast Neoplasms, Colonic Neoplasms, Depression

NCT04117087 2025-12-03

Pooled Mutant KRAS-Targeted Long Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Resected Mismatch Repair Protein (MMR-p) Colorectal and Pancreatic Cancer

27 enrolled

Colonic Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT03432806 2025-12-02

A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver Tumors

51 enrolled

Colonic Neoplasms, Carcinoma, Hepatocellular

NCT04017650 2025-11-20

Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer

38 enrolled

Phase 2 Active not recruiting

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Disease Progression

NCT06714292 2025-11-19

FLARECLIP

110 enrolled

Colonic Neoplasms

NCT02293954 2025-11-14

Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer

BreastGastrointestinalThoracic

20 enrolled 8 charts

Bile Duct Neoplasms, Breast Neoplasms, Colonic Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Rectal Neoplasms, Carcinoma, Medullary

NCT00600496 2025-11-13

A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)

BreastDermatologicGastrointestinalGenitourinaryThoracic

140 enrolled

Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Lung Neoplasms, Melanoma, Neoplasms

NCT05627635 2025-11-10

FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer

20 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00996710 2025-11-04

Genomic Structural Variation in Cancer Susceptibility

BreastCNSGastrointestinalSarcoma

1,275 enrolled

Breast Neoplasms, Colonic Neoplasms, Neoplasms, Germ Cell and Embryonal, Neuroblastoma, Rectal Neoplasms, Sarcoma

NCT02863107 2025-10-27

Young-Onset Colorectal Cancer

818 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03157128 2025-10-20

LIBRETTO-001