Clinical Trials

400 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplasms

NCT02194387 2026-03-09

Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members

BreastGastrointestinalGynecologicLymphoidOther hematologic neoplasm

337 enrolled

Breast Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Fatigue, Ovarian Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Overweight

NCT05677048 2026-03-09

Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention

205 enrolled

Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Ovarian Neoplasms, Pancreatic Neoplasms, Uterine Neoplasms, Endometrial Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT07450612 2026-03-04

BEACON

1,200 enrolled

Phase 1/2 Active not recruiting

Turcot syndrome, Lynch syndrome I (site-specific colonic cancer), Colonic Diseases, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms, Lynch Syndrome II

NCT05078866 2026-03-03

Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients

45 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT07445828 2026-03-03

Lynch syndrome

Not yet recruiting

78 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT07220239 2026-03-02

SCREEN-CUP

25 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Endometrial Neoplasms

NCT07436312 2026-02-27

U-TRANS

170 enrolled

BreastGastrointestinal

Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Pancreatic Neoplasms

NCT06994832 2026-02-18

Using Visual Arrays to Support Understanding of Genetic Risk

1,045 enrolled

Phase 1/2 Not yet recruiting

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT07412197 2026-02-17

PREVENT-Lynch

23 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT03050268 2026-02-09

SJFAMILY

BreastCNSClassical hematologyDermatologicEndocrineGastrointestinalGynecologicLymphoidOther solid neoplasmSarcoma

1,500 enrolled

Turcot syndrome, Juvenile polyposis syndrome, Choroid Plexus Carcinoma, GATA2 Deficiency, Basal Cell Nevus Syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Fanconi Anemia, Hamartoma Syndrome, Multiple, von Hippel-Lindau Disease, Hodgkin Disease, Lymphoma, Non-Hodgkin, Melanoma, Neuroblastoma, Neurofibromatosis 1, Noonan Syndrome, Pancreatic Neoplasms, Paraganglioma, Peutz-Jeghers Syndrome, Pheochromocytoma, Rothmund-Thomson Syndrome, Adenomatous Polyposis Coli, Retinoblastoma, Rhabdomyosarcoma, Tuberous Sclerosis, Neurofibromatosis 2, Li-Fraumeni Syndrome, Adrenocortical Carcinoma, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2a, Dyskeratosis Congenita, Genetic Predisposition to Disease, Anemia, Diamond-Blackfan, Carney Complex, Hereditary Breast and Ovarian Cancer Syndrome

NCT02371135 2026-02-05

Metagenomic Evaluation of the Gut Microbiome in Patients With Lynch Syndrome and Other Hereditary Colonic Polyposis Syndromes

77 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT07304063 2026-02-03

Overcoming Barriers to Uptake of Cascade Screening

20 enrolled

Phase 3 Active not recruiting

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT02912559 2026-02-02

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

712 enrolled

Phase NA Enrolling by invitation

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Repair-Deficiency Disorders

NCT07381985 2026-02-02

LINC

200 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary

NCT04494945 2026-01-23

Identifying and Caring for Individuals With Inherited Cancer Syndrome

27,500 enrolled

Carcinoma, Intraductal, Noninfiltrating, Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Hereditary Breast and Ovarian Cancer Syndrome

NCT07360834 2026-01-23

PREDI-LYNCH

2,000 enrolled

Turcot syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis

NCT02012699 2026-01-22

iCaRe2

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther hematologic neoplasmOther solid neoplasmPlasma cellSarcomaThoracic

999,999 enrolled

Anus Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Duodenal Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Lip Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Mesothelioma, Mouth Neoplasms, Multiple Myeloma, Nasopharyngeal Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Paranasal Sinus Neoplasms, Paraproteinemias, Penile Neoplasms, Peritoneal Neoplasms, Adenomatous Polyposis Coli, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Sarcoma, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Ureteral Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Central Nervous System Neoplasms, Thyroid Nodule, Endometrial Neoplasms, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors

NCT06426927 2026-01-21

PeLear CCC

60 enrolled 13 charts

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Rectal Neoplasms, Colorectal Neoplasms

NCT04261972 2026-01-14

CHARM1

1,416 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplasms, Neoplastic Syndromes, Hereditary, Hereditary Breast and Ovarian Cancer Syndrome

NCT04407611 2026-01-12

BWHS RoR

932 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Breast and Ovarian Cancer Syndrome

NCT03805919 2026-01-08

Men at High Genetic Risk for Prostate Cancer

500 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Prostatic Neoplasms

NCT05692596 2026-01-08

The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

317 enrolled

Ataxia Telangiectasia, Colorectal Neoplasms, Hereditary Nonpolyposis, Dysplastic Nevus Syndrome, Pancreatic Cyst, Peutz-Jeghers Syndrome, Pancreatitis, Chronic

NCT00582296 2026-01-07

Multi-Organ Screening Recommendations in Patients With Lynch Syndrome

1,530 enrolled

Phase NA Enrolling by invitation

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT07106359 2026-01-07

Initial Testing of a Behavioral Intervention About Genetic Services for Families at Risk of Lynch Syndrome

185 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Uterine Neoplasms, Colorectal Neoplasms

NCT07077447 2025-12-22

EuroCUT

2,500 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT06726642 2025-12-16

CHARM2

1,000 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Stomach Neoplasms, Li-Fraumeni Syndrome, Hereditary Breast and Ovarian Cancer Syndrome

NCT07219537 2025-12-16

A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule

30 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Crohn Disease, Inflammatory Bowel Diseases

NCT07163403 2025-12-04

DELAY

Phase 1 Recruiting

20 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT06218433 2025-11-18

Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)

200 enrolled

Urogenital Diseases, Urinary Bladder Neoplasms, Carcinoma, Transitional Cell, Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary

NCT07201012 2025-11-17

SMT-SL

DermatologicGastrointestinal

150 enrolled

Carcinoma, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Colorectal Neoplasms, Hereditary Nonpolyposis, Skin Neoplasms, Muir-Torre Syndrome

NCT05411718 2025-11-13

A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome

Phase 2 Recruiting

40 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT04125914 2025-11-03

Weight Management and Health Behavior Intervention in Lowering Cancer Risk for BRCA Positive and Lynch Syndrome Families

384 enrolled

BreastGastrointestinal

Breast Cancer, Familial, Colorectal Neoplasms, Hereditary Nonpolyposis

NCT02000089 2025-10-09

CAPS5

Phase 3 Recruiting

9,000 enrolled

BreastGastrointestinal

Hereditary pancreatitis, Breast Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Dysplastic Nevus Syndrome, Hereditary Sensory and Autonomic Neuropathies, Pancreatic Neoplasms, Peutz-Jeghers Syndrome

NCT03460483 2025-10-03

OPTEC

1,001 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Endometrial Neoplasms

NCT00261456 2025-09-26

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer

3,500 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Prostatic Neoplasms, Genetic Predisposition to Disease

NCT02705846 2025-09-26

GENPROS

4,260 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Prostatic Neoplasms

NCT07194551 2025-09-26

Lynch-SCAN

30 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Endometrial Neoplasms

NCT03426878 2025-09-11

CHARM

967 enrolled 13 charts

CNSGastrointestinalLymphoidOther hematologic neoplasm

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Hereditary Breast and Ovarian Cancer Syndrome

NCT04500548 2025-09-10

Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study

Phase 1 Withdrawn

Turcot syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Lymphoma, Neuroblastoma, Xeroderma Pigmentosum, Central Nervous System Neoplasms, Hematologic Neoplasms

NCT06898996 2025-09-08

FITting Non-invasive Tests in Lynch Syndrome Surveillance

400 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT07160010 2025-09-08

COSMOS

Not yet recruiting

248 enrolled

Breast Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Ovarian Neoplasms, Intestinal Polyposis

NCT05963191 2025-09-03

CADLYNCH

272 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT05410977 2025-08-17

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

750 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT06989814 2025-08-11

SMART

50 enrolled

Phase EARLY_PHASE1 Completed

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT04379999 2025-08-07

Atorvastatin ± Aspirin in Lynch Syndrome Syndrome

43 enrolled

Phase NA Enrolling by invitation

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT06914726 2025-08-05

PC-CDS

2,488 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Ovarian Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT04978350 2025-07-03

Overcoming Barriers to the Uptake of Cascade Screening for Lynch Syndrome: Workbook Feasibility Study

20 enrolled 6 charts