Clinical Trials

400 enrolled

Phase NA Active not recruiting

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplasms

NCT02194387 2026-03-09

Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members

337 enrolled

BreastGastrointestinalGynecologicLymphoidOther hematologic neoplasm

Breast Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Fatigue, Ovarian Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Overweight

NCT05677048 2026-03-09

Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention

Phase NA Active not recruiting

205 enrolled

Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Ovarian Neoplasms, Pancreatic Neoplasms, Uterine Neoplasms, Endometrial Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT07450612 2026-03-04

BEACON

1,200 enrolled

Phase 1/2 Active not recruiting

Turcot syndrome, Lynch syndrome I (site-specific colonic cancer), Colonic Diseases, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms, Lynch Syndrome II

NCT05078866 2026-03-03

Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients

45 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT07445828 2026-03-03

Lynch syndrome

Not yet recruiting

78 enrolled

GastrointestinalGynecologic

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT07220239 2026-03-02

SCREEN-CUP

Phase NA Recruiting

25 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Endometrial Neoplasms

NCT07436312 2026-02-27

U-TRANS

Phase NA Not yet recruiting

170 enrolled

BreastGastrointestinal

Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Pancreatic Neoplasms

NCT06994832 2026-02-18

Using Visual Arrays to Support Understanding of Genetic Risk

Phase NA Completed

1,045 enrolled

Phase 1/2 Not yet recruiting

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms

NCT07412197 2026-02-17

PREVENT-Lynch

23 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT03050268 2026-02-09

SJFAMILY

BreastCNSClassical hematologyDermatologicEndocrineGastrointestinalGynecologicLymphoidOther solid neoplasmSarcoma

1,500 enrolled

Turcot syndrome, Juvenile polyposis syndrome, Choroid Plexus Carcinoma, GATA2 Deficiency, Basal Cell Nevus Syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Fanconi Anemia, Hamartoma Syndrome, Multiple, von Hippel-Lindau Disease, Hodgkin Disease, Lymphoma, Non-Hodgkin, Melanoma, Neuroblastoma, Neurofibromatosis 1, Noonan Syndrome, Pancreatic Neoplasms, Paraganglioma, Peutz-Jeghers Syndrome, Pheochromocytoma, Rothmund-Thomson Syndrome, Adenomatous Polyposis Coli, Retinoblastoma, Rhabdomyosarcoma, Tuberous Sclerosis, Neurofibromatosis 2, Li-Fraumeni Syndrome, Adrenocortical Carcinoma, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2a, Dyskeratosis Congenita, Genetic Predisposition to Disease, Anemia, Diamond-Blackfan, Carney Complex, Hereditary Breast and Ovarian Cancer Syndrome

NCT02371135 2026-02-05

Metagenomic Evaluation of the Gut Microbiome in Patients With Lynch Syndrome and Other Hereditary Colonic Polyposis Syndromes

77 enrolled

Phase NA Not yet recruiting

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT07304063 2026-02-03

Overcoming Barriers to Uptake of Cascade Screening

20 enrolled

Phase 3 Active not recruiting

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT02912559 2026-02-02

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

712 enrolled

Phase NA Enrolling by invitation

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Repair-Deficiency Disorders

NCT07381985 2026-02-02

LINC

200 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary

NCT04494945 2026-01-23

Identifying and Caring for Individuals With Inherited Cancer Syndrome

Phase NA Recruiting

27,500 enrolled

Phase NA Not yet recruiting

Carcinoma, Intraductal, Noninfiltrating, Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Hereditary Breast and Ovarian Cancer Syndrome

NCT07360834 2026-01-23

PREDI-LYNCH

2,000 enrolled

Turcot syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis

NCT02012699 2026-01-22

iCaRe2

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther hematologic neoplasmOther solid neoplasmPlasma cellSarcomaThoracic

999,999 enrolled

Anus Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Duodenal Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Lip Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Mesothelioma, Mouth Neoplasms, Multiple Myeloma, Nasopharyngeal Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Paranasal Sinus Neoplasms, Paraproteinemias, Penile Neoplasms, Peritoneal Neoplasms, Adenomatous Polyposis Coli, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Sarcoma, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Ureteral Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Central Nervous System Neoplasms, Thyroid Nodule, Endometrial Neoplasms, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors

NCT06426927 2026-01-21

PeLear CCC

Phase NA Completed

60 enrolled 13 charts

Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Rectal Neoplasms, Colorectal Neoplasms

NCT04261972 2026-01-14

CHARM1

1,416 enrolled

Phase NA Active not recruiting

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplasms, Neoplastic Syndromes, Hereditary, Hereditary Breast and Ovarian Cancer Syndrome

NCT04407611 2026-01-12

BWHS RoR

932 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Breast and Ovarian Cancer Syndrome

NCT03805919 2026-01-08

Men at High Genetic Risk for Prostate Cancer

GastrointestinalGenitourinary

500 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Prostatic Neoplasms

NCT05692596 2026-01-08

The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

317 enrolled

Ataxia Telangiectasia, Colorectal Neoplasms, Hereditary Nonpolyposis, Dysplastic Nevus Syndrome, Pancreatic Cyst, Peutz-Jeghers Syndrome, Pancreatitis, Chronic

NCT00582296 2026-01-07

Multi-Organ Screening Recommendations in Patients With Lynch Syndrome

1,530 enrolled

Phase NA Enrolling by invitation

Colorectal Neoplasms, Hereditary Nonpolyposis

NCT07106359 2026-01-07

Initial Testing of a Behavioral Intervention About Genetic Services for Families at Risk of Lynch Syndrome

185 enrolled

GastrointestinalGynecologic

Colorectal Neoplasms, Hereditary Nonpolyposis, Uterine Neoplasms, Colorectal Neoplasms

NCT07077447 2025-12-22

EuroCUT

2,500 enrolled