Clinical Trials Browser

Phase 3 × Colorectal Neoplasms × Leucovorin × Clear all

NCT02997228 2026-03-18

Testing the Addition of Atezolizumab to Combination Chemotherapy or Atezolizumab Alone for Metastatic Colon or Rectal Cancer, the COMMIT Study

Phase 3 Active not recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05253651 2026-03-16

MOUNTAINEER-03

Phase 3 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05239741 2026-03-10

MK-3475-C66

Phase 3 Recruiting

Gastrointestinal

Parkinson Disease 4, Autosomal Dominant Lewy Body, Colorectal Neoplasms

NCT04230187 2026-03-05

TRIBE-C

Phase 3 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT07228832 2026-03-03

HARMONi-GI3

Phase 3 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05863195 2026-03-02

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

Phase 3 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05008809 2025-12-12

AIO-KRK-0418

Phase 3 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT07271355 2025-12-09

Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial

Phase 3 Not yet recruiting

Gastrointestinal

Appendiceal Neoplasms, Colorectal Neoplasms

NCT06733038 2025-12-08

AtezoTRIBE2

Phase 3 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT06783491 2025-11-24

FOXHIPECT4

Phase 3 Not yet recruiting

Gastrointestinal

Colorectal Neoplasms

NCT04008030 2025-10-03

CheckMate 8HW

Phase 3 Active not recruiting

839 enrolled 22 charts 1 FDA

Gastrointestinal

Colorectal Neoplasms

NCT04776655 2025-10-02

LIBImAb

Phase 3 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT04607421 2025-08-14

A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer

Phase 3 Active not recruiting

831 enrolled 2 FDA

Gastrointestinal

Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Rectal Diseases, Rectal Neoplasms, Colorectal Neoplasms

NCT03828227 2025-07-18

COLAGE

Phase 3 Active not recruiting

Gastrointestinal

Colorectal Neoplasms

NCT02885753 2025-07-09

OSCAR

Phase 3 Recruiting

Gastrointestinal

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT02934529 2025-04-16

AIO-KRK-0114

Phase 3 Completed

Gastrointestinal

Colorectal Neoplasms

NCT01167725 2024-12-27

Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer

Phase 3 Terminated

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms

NCT04456699 2024-10-29

LYNK-003

Phase 3 Completed

335 enrolled 19 charts

Gastrointestinal

Colorectal Neoplasms

NCT06509126 2024-07-19

IMPROVE-2

Phase 3 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT05954078 2024-05-20

Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for High-risk Stage II/III Colorectal Cancer

Phase 3 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT02928224 2023-12-21

BEACON CRC

Phase 3 Completed

702 enrolled 82 charts 2 FDA

Gastrointestinal

Colorectal Neoplasms

NCT02753127 2023-11-15

CanStem303C

Phase 3 Completed

1,253 enrolled 18 charts

Gastrointestinal

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Rectal Diseases, Colorectal Neoplasms

NCT00958737 2023-09-29

IDEA

Phase 3 Unknown

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms

NCT00002525 2023-06-28

Perioperative Chemotherapy in Treating Patients With Colon Cancer That Can Be Surgically Removed

Phase 3 Terminated

859 enrolled 8 charts

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms

NCT01718873 2023-04-12

OBELICS

Phase 3 Completed

230 enrolled 12 charts

Gastrointestinal

Neoplasm Metastasis, Colorectal Neoplasms

NCT03391934 2023-04-05

Comparing Efficacy and Safety of Cetuximab (CinnaGen) Versus Erbitux® (Merck) in Metastatic Colorectal Cancer

Phase 3 Unknown

Gastrointestinal

Colorectal Neoplasms

NCT03231722 2023-01-05

TRIPLETE

Phase 3 Completed

Gastrointestinal

Colorectal Neoplasms

NCT01150045 2022-03-22

Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery

Phase 3 Unknown

2,527 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms

NCT00070213 2021-09-27

Leucovorin and Fluorouracil With or Without Oxaliplatin Compared to Capecitabine With or Without Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer

Phase 3 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03288987 2021-01-22

Comparing Efficacy and Safety of Stivant (AryoGen Bevacizumab) Versus Avastin in Metastatic Colorectal Cancer

Phase 3 Completed

126 enrolled 15 charts

Gastrointestinal

Colorectal Neoplasms

NCT00023868 2020-12-02

Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver (6655)

Phase 3 Terminated

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT03300609 2020-06-11

5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab

Phase 3 Terminated

Gastrointestinal

Colorectal Neoplasms

NCT00265850 2020-05-07

Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer

Phase 3 Completed

2,334 enrolled 9 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00003594 2020-04-29

Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer

Phase 3 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00002570 2020-04-06

Immediate Compared With Delayed Chemotherapy in Advanced Colorectal Cancer Without Signs or Symptoms of Disease

Phase 3 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00069121 2020-03-06

A Study of Xeloda (Capecitabine) Plus Oxaliplatin in Patients With Colon Cancer

Phase 3 Completed

1,886 enrolled 16 charts

Gastrointestinal

Colorectal Neoplasms

NCT01228734 2020-01-28

TAILOR

Phase 3 Completed

553 enrolled 13 charts

Gastrointestinal

Colorectal Neoplasms

NCT02251977 2019-10-07

Effect of GM1 in Prevention of Oxaliplatin Induced Neurotoxicity in Stage II/III Colorectal Cancer

Phase 3 Completed

Gastrointestinal

Colorectal Neoplasms

NCT01183780 2019-09-25

A Study in Second Line Metastatic Colorectal Cancer

Phase 3 Completed

1,072 enrolled 17 charts

Gastrointestinal

Colorectal Neoplasms

NCT01996306 2019-01-08

AXEPT

Phase 3 Completed

Gastrointestinal

Digestive System Neoplasms, Gastrointestinal Neoplasms, Intestinal Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT00077233 2018-05-16

FOLFIRI or FOLFOX With or Without Cetuximab in Patients With Metastatic Adenocarcinoma of the Colon or Rectum

Phase 3 Terminated

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01279681 2017-12-08

Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer

Phase 3 Terminated

32 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Neurotoxicity Syndromes

NCT03303495 2017-10-06

A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC

Phase 3 Unknown

Gastrointestinal

Digestive System Neoplasms, Gastrointestinal Neoplasms, Intestinal Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT01308086 2017-08-09

Adjuvant Therapy(3 vs. 6 Months) With the FOLFOX 4 or XELOX for Stage II or Stage III Colon Cancer

Phase 3 Unknown

Gastrointestinal

Neoplasms, Colorectal Neoplasms

NCT00154102 2017-01-30

CRYSTAL

Phase 3 Completed

1,221 enrolled 24 charts

Gastrointestinal

Colorectal Neoplasms

NCT00399035 2016-12-28

HORIZON II

Phase 3 Completed

1,254 enrolled 14 charts

Gastrointestinal

Colorectal Neoplasms

NCT00069095 2016-10-06

A Study of Capecitabine (Xeloda) and Bevacizumab as a First-line Therapy in Patients With Metastatic Colorectal Cancer

Phase 3 Completed

2,035 enrolled 33 charts

Gastrointestinal

Colorectal Neoplasms

NCT00002523 2016-09-02

Radiation Therapy, Surgery, and Chemotherapy in Treating Patients With Rectal Cancer That Can Be Surgically Removed

Phase 3 Completed

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT00769405 2016-08-30

Systemic Chemotherapy With or Without Intraperitoneal Chemohyperthermia in Treating Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer

Phase 3 Completed

GastrointestinalGynecologic

Colonic Neoplasms, Peritoneal Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00660894 2016-08-03

Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery

Phase 3 Completed

Gastrointestinal

Colonic Neoplasms, Colorectal Neoplasms