NCT05382364 2026-03-12Safety and Pharmacokinetics of Tucatinib (MK-7119) in Chinese Participants With Cancer (MK-7119-002)PfizerPhase 1 Active not recruiting25 enrolled
NCT07318389 2026-02-27ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal CancerM.D. Anderson Cancer CenterPhase EARLY_PHASE1 Not yet recruiting100 enrolled
NCT04430738 2026-02-24Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal CancersSeagen Inc.Phase 2 Active not recruiting40 enrolled 67 charts
NCT03043313 2024-11-26Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal CancerSeagen Inc.Phase 2 Completed117 enrolled 21 charts 1 FDA
NCT05356897 2024-09-19Tucatinib Combined with Trastuzumab and TAS-102 for the Treatment of HER2 Positive Metastatic Colorectal Cancer in Molecularly Selected Patients, 3T StudyAcademic and Community Cancer Research UnitedPhase 2 Withdrawn
NCT05091528 2022-08-18A Safety and Activity Study of SBT6050 in Combination With Other HER2-directed Therapies for HER2-positive CancersSilverback TherapeuticsPhase 1/2 Terminated2 enrolled 9 charts