Clinical Trials

68 enrolled 11 charts

Ependymoma

NCT01356290 2026-02-23

MEMMAT

Phase 2 Recruiting

232 enrolled

Phase 2 Not yet recruiting

Ependymoma, Medulloblastoma, Recurrence

NCT07424092 2026-02-20

PED-DNX2401

39 enrolled

Ependymoma, Glioma, Recurrence

NCT03911388 2026-02-17

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

24 enrolled

CNSSarcoma

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT05957679 2026-02-12

MRE Evaluation for Spinal Cord Tumor Surgery: Stiffness and Adhesion Assessment

Phase NA Recruiting

20 enrolled

Phase 1 Not yet recruiting

Astrocytoma, Ependymoma, Glioblastoma, Glioma, Meningioma, Neurofibroma, Spinal Cord Neoplasms

NCT01795313 2026-02-05

Immunotherapy for Recurrent Ependymomas in Children Using Tumor Antigen Peptides With Imiquimod

Phase 1 Terminated

23 enrolled

Ependymoma

NCT07390539 2026-02-05

B7-H3.CD28Z.CART in CNS Neoplasms

70 enrolled

Brain Neoplasms, Ependymoma, Medulloblastoma, Meningeal Neoplasms, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT00840047 2026-01-20

Methionine PET/CT Studies In Patients With Cancer

503 enrolled

CNSLymphoidSarcoma

Craniopharyngioma, Ependymoma, Hodgkin Disease, Lymphoma, Non-Hodgkin, Medulloblastoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT05835687 2026-01-20

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

48 enrolled

Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Central Nervous System Neoplasms, Rhabdoid Tumor

NCT04374305 2026-01-12

INTUITT-NF2

100 enrolled

Ependymoma, Meningioma, Neuroma, Acoustic, Neurofibromatosis 2

NCT05106296 2026-01-09

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

37 enrolled

Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT04049669 2026-01-08

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

130 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma

NCT06466798 2026-01-08

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

Phase 1 Withdrawn

Phase 1 Active not recruiting

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms

NCT07031765 2025-12-18

Peds CHAMP1ON

12 enrolled

Phase 1 Active not recruiting

Astrocytoma, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma

NCT03500991 2025-12-17

HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

10 enrolled

Choroid Plexus Carcinoma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT03638167 2025-12-17

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

Phase 1 Completed

11 enrolled

Choroid Plexus Carcinoma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT04185038 2025-12-15

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

90 enrolled

Choroid Plexus Carcinoma, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT02238899 2025-12-04

Multicenter Register for Children and Young Adults With Intracranial Localized Medulloblastoma, CNS-PNET or Ependymoma

Completed

354 enrolled

Ependymoma, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT02417324 2025-12-04

International HIT-MED Registry (I-HIT-MED)

Recruiting

500 enrolled

Ependymoma, Medulloblastoma, Pinealoma

NCT03750513 2025-11-13

LET Optimized IMPT in Treating Pediatric Patients With Ependymoma

CNSGastrointestinalGenitourinarySarcoma

48 enrolled

Ependymoma

NCT02162732 2025-11-03

Molecular-Guided Therapy for Childhood Cancer

Phase NA Completed

186 enrolled 12 charts

Carcinoma, Renal Cell, Craniopharyngioma, Ependymoma, Glioma, Carcinoma, Hepatocellular, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Choroid Plexus Neoplasms, Sarcoma, Clear Cell, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT05341947 2025-10-22

Activated Autologous T Cells Against Glioma Cancer Stem Cell Antigens for Patients With Recurrent Glioblastoma

Phase 1 Withdrawn

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma

NCT05278208 2025-10-20

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

Phase 1/2 Recruiting

65 enrolled

Phase 2 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Central Nervous System Neoplasms

NCT06804655 2025-10-02

EViDENCE-BT

40 enrolled

Phase EARLY_PHASE1 Completed

Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Neurologic Manifestations

NCT01165632 2025-09-02

Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma

24 enrolled

CNSSarcoma

Astrocytoma, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Glioma, Subependymal, Gliosarcoma

NCT03220646 2025-07-09

Abemaciclib (LY2835219) in Patients With Recurrent Primary Brain Tumors

64 enrolled

Astrocytoma, Brain Neoplasms, Ependymoma, Meningioma, Oligodendroglioma

NCT03128047 2025-07-08

HUMC 1612: Optune NovoTTF-200A System

Phase 1 Completed

7 enrolled 12 charts

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms

NCT04743310 2025-06-13

Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System

Phase 2 Completed

50 enrolled

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Neuroma, Acoustic, Pinealoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT01288235 2025-06-03

Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation

Phase 2 Completed

100 enrolled 11 charts

Astrocytoma, Brain Neoplasms, Ependymoma, Ganglioglioma

NCT02186509 2025-04-30

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas

Phase 1 Completed

17 enrolled 11 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT03095248 2025-04-22

SEL-TH-1601

Phase 2 Terminated

10 enrolled 9 charts

Ependymoma, Glioma, Meningioma, Neuroma, Acoustic, Neurofibromatosis 2

NCT06779487 2025-04-11

BIO-RIN

Recruiting

200 enrolled

Phase 2 Not yet recruiting

Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma

NCT06678867 2025-03-27

P5A

80 enrolled

Phase EARLY_PHASE1 Completed

Brain Neoplasms, Ependymoma, Glioma

NCT02905110 2025-03-25

Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children with Recurrent Posterior Fossa Brain Tumors

3 enrolled

Brain Neoplasms, Ependymoma, Medulloblastoma, Rhabdoid Tumor

NCT06323408 2025-03-25

BZKF-AYA

Not yet recruiting

72 enrolled