Clinical Trials

157 enrolled

Gastrointestinal Stromal Tumors

NCT05489237 2025-11-17

First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors

278 enrolled

GastrointestinalHead & NeckSarcomaThoracic

Digestive System Diseases, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Neoplasm Metastasis, Gastrointestinal Stromal Tumors

NCT04000529 2025-09-30

Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies

Phase 1 Terminated

122 enrolled

Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms, Gastrointestinal Stromal Tumors

NCT06805825 2025-09-23

A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

DermatologicEndocrineGastrointestinalGenitourinaryNETSarcomaThoracic

67 enrolled

Uveal Melanoma, Carcinoma, Renal Cell, Carcinoma, Adenoid Cystic, Piebaldism, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors, Small Cell Lung Carcinoma

NCT03594422 2025-02-27

A Study of HQP1351 in Patients With GIST or Other Solid Tumors

100 enrolled

Gastrointestinal Stromal Tumors

NCT04908176 2024-12-13

A Drug-drug Interaction Study of Avapritinib and Midazolam

CNSGastrointestinalSarcoma

10 enrolled

Glioblastoma, Neoplasms, Recurrence, Gastrointestinal Stromal Tumors

NCT04530981 2024-09-19

A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST

13 enrolled

BreastDermatologicGastrointestinalGenitourinarySarcoma

Gastrointestinal Stromal Tumors

NCT04714983 2024-04-09

DNX-2440 for Resectable Colorectal Liver Metastasis

Phase 1 Suspended

30 enrolled

Breast Neoplasms, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Melanoma, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Gastrointestinal Stromal Tumors

NCT04276415 2024-02-15

DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST)

Phase 1 Terminated

34 enrolled 27 charts

Gastrointestinal Stromal Tumors

NCT02571036 2023-12-13

A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies

CNSDermatologicGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmSarcomaThoracic

282 enrolled

Mast Cell Activation Disorders, Carcinoma, Non-Small-Cell Lung, Glioma, Leukemia, Mast-Cell, Melanoma, Neoplasms, Germ Cell and Embryonal, Penile Neoplasms, Sarcoma, Mastocytosis, Systemic, Gastrointestinal Stromal Tumors, Renal Insufficiency

NCT05800106 2023-04-10

A Bioequivalence Study of Sunitinib Malate Capsules.

GastrointestinalGenitourinarySarcoma

24 enrolled

Carcinoma, Renal Cell, Adenoma, Islet Cell, Gastrointestinal Stromal Tumors

NCT02508532 2022-06-21

(NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors

250 enrolled 36 charts 2 FDA

Gastrointestinal Stromal Tumors

NCT00135005 2020-12-08

Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)

59 enrolled

Gastrointestinal Stromal Tumors

NCT02574663 2019-10-02

TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors

66 enrolled

Esophageal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Gastrointestinal Stromal Tumors

NCT02686944 2019-07-05

GIST

6 enrolled

Gastrointestinal Stromal Tumors

NCT01751919 2014-10-01

A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I)

GastrointestinalMyeloidOther hematologic neoplasmSarcoma

37 enrolled

Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Gastrointestinal Stromal Tumors

NCT01381822 2014-04-21

TH-CR-410

Phase 1 Unknown

58 enrolled

Neuroectodermal Tumors, Primitive, Gastrointestinal Stromal Tumors

NCT00441155 2013-05-13

Patients Completing Core Protocol (CAMN107A2103), Exhibiting Stable Disease (SD), Partial Response (PR) or Complete Response (CR) to Nilotinib in Combination With Imatinib

14 enrolled

Neoplasms, Gastrointestinal Stromal Tumors

NCT01270984 2012-10-31

Imatinib

GastrointestinalMyeloidOther hematologic neoplasmSarcoma

30 enrolled

Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Gastrointestinal Stromal Tumors

NCT00513851 2011-09-27

Phase 1 Study of OSI-930 in Cancer Patients

GastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

60 enrolled

Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Uterine Neoplasms, Colorectal Neoplasms, Gastrointestinal Stromal Tumors, Small Cell Lung Carcinoma

NCT00276302 2011-01-06

Safety Study of IPI-504 in Patients With Gastrointestinal Stromal Tumors (GIST) or Soft Tissue Sarcomas (STS)

63 enrolled