Clinical Trials Browser

Phase 2 × Glioblastoma × 90 days × Clear all

NCT03919071 2026-03-18

Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

Phase 2 Active not recruiting

Astrocytoma, Glioblastoma, Glioma

NCT04145115 2026-03-18

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden

Phase 2 Active not recruiting

Astrocytoma, Glioblastoma

NCT04817254 2026-03-18

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Phase 2 Active not recruiting

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT06325683 2026-03-18

Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

Phase 2 Recruiting

Glioblastoma

NCT07476794 2026-03-17

TEMPO

Phase 2 Recruiting

Glioblastoma

NCT05753007 2026-03-16

A Clinical Trial of a Hemp-Derived, High Cannabidiol Product for Anxiety in Glioblastoma Patients

Phase 2 Terminated

2 enrolled 13 charts

Glioblastoma

NCT03475186 2026-03-13

Testing Ramipril to Prevent Memory Loss in People With Glioblastoma

Phase 2 Completed

75 enrolled 47 charts

Brain Neoplasms, Glioblastoma, Cognitive Dysfunction

NCT07297212 2026-03-12

A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and How Well it Works in Patients With Recurrent Glioblastoma

Phase 2 Recruiting

Brain Neoplasms, Glioblastoma

NCT04044937 2026-03-11

UC-GlioFET

Phase 2 Completed

Brain Neoplasms, Glioblastoma

NCT07462507 2026-03-10

Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

Phase 2 Not yet recruiting

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT05463848 2026-03-04

Surgical Pembro +/- Olaparib w TMZ for rGBM

Phase 2 Recruiting

Glioblastoma

NCT05607407 2026-03-04

Methimazole in Patients With Progressive Glioblastoma

Phase 2 Recruiting

Glioblastoma, Glioma

NCT05843253 2026-03-04

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Phase 2 Recruiting

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT06319027 2026-03-02

GABLE

Phase 2 Recruiting

Glioblastoma

NCT07439172 2026-02-27

PRC

Phase 2 Not yet recruiting

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma

NCT01068782 2026-02-25

Multiple Doses and Regimens of Cabozantinib in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse

Phase 2 Terminated

19 enrolled 10 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT02455557 2026-02-25

SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Phase 2 Active not recruiting

66 enrolled 11 charts

Glioblastoma, Gliosarcoma

NCT06058988 2026-02-23

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Phase 2 Recruiting

Brain Neoplasms, Glioblastoma, Neoplasm Metastasis, Meningeal Carcinomatosis

NCT06805305 2026-02-23

DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM)

Phase 2 Recruiting

Glioblastoma

NCT03212274 2026-02-19

Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations

Phase 2 Active not recruiting

CNSGastrointestinal

Glioblastoma, Glioma, Cholangiocarcinoma

NCT04765514 2026-02-13

Chemoradiotherapy Versus Chemotherapy for Elderly and Frail GBM Patients

Phase 2 Recruiting

Glioblastoma

NCT07263438 2026-02-13

Phenix

Phase 2 Recruiting

Glioblastoma, Recurrence

NCT06061809 2026-02-12

N-803 and PD-L1 t-haNK Combined With Bevacizumab for Recurrent or Progressive Glioblastoma

Phase 2 Recruiting

Glioblastoma

NCT04485949 2026-02-10

A Phase 2b Clinical Study With a Combination Immunotherapy in Newly Diagnosed Patients With Glioblastoma

Phase 2 Active not recruiting

Glioblastoma

NCT03405792 2026-02-06

2-THE-TOP

Phase 2 Active not recruiting

40 enrolled 11 charts

Glioblastoma

NCT07225621 2026-02-05

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

Phase 2 Recruiting

Glioblastoma

NCT05653622 2026-02-04

SIB-DOPA

Phase 2 Recruiting

Glioblastoma

NCT05781321 2026-02-03

Short Course Radiotherapy for the Treatment of Patients With Glioblastoma, SAGA Study

Phase 2 Active not recruiting

Glioblastoma

NCT07301268 2026-02-03

GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma

Phase 2 Suspended

Astrocytoma, Glioblastoma, Gliosarcoma

NCT02394626 2026-02-02

RESURGE

Phase 2 Recruiting

Glioblastoma

NCT05629702 2026-01-30

ARISTOCRAT

Phase 2 Recruiting

Brain Neoplasms, Marijuana Abuse, Glioblastoma, Recurrence

NCT04752813 2026-01-26

A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)

Phase 2 Active not recruiting

Glioblastoma

NCT07356973 2026-01-26

OPTICAL

Phase 2 Not yet recruiting

Glioblastoma

NCT07365280 2026-01-26

Neoantigen-Pulsed Autologous Dendritic Cell Vaccine Combined With Temozolomide for Newly Diagnosed Glioblastoma

Phase 2 Not yet recruiting

Glioblastoma

NCT07364786 2026-01-23

AFGBMBiop

Phase 2 Recruiting

Glioblastoma

NCT02179086 2026-01-14

Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Phase 2 Active not recruiting

Glioblastoma

NCT04623931 2026-01-14

Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas

Phase 2 Recruiting

Astrocytoma, Glioblastoma, Oligodendroglioma

NCT05465954 2026-01-12

Efineptakin Alfa and Pembrolizumab for the Treatment of Recurrent Glioblastoma

Phase 2 Recruiting

Glioblastoma, Gliosarcoma

NCT05871021 2026-01-09

PRIDE

Phase 2 Recruiting

Glioblastoma

NCT04049669 2026-01-08

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

Phase 2 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma

NCT04221503 2026-01-08

Niraparib/TTFields in GBM

Phase 2 Active not recruiting

Glioblastoma

NCT03743662 2026-01-07

Nivolumab With Radiation Therapy and Bevacizumab for Recurrent MGMT Methylated Glioblastoma

Phase 2 Active not recruiting

Glioblastoma

NCT06558214 2026-01-07

OPTIMUS PRIME

Phase 2 Recruiting

Glioblastoma

NCT02617745 2026-01-02

GLIOPLAK

Phase 2 Completed

CNSClassical hematology

Glioblastoma, Thrombocytopenia

NCT04959500 2026-01-02

Newly Diagnosed Glioblastoma

Phase 2 Active not recruiting

Glioblastoma

NCT05267106 2025-12-30

FIGHT-209

Phase 2 Terminated

83 enrolled 18 charts

Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT05708352 2025-12-24

A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment

Phase 2 Recruiting

Glioblastoma

NCT07285044 2025-12-22

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

Phase 2 Recruiting

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicLymphoidMyeloidPlasma cellThoracic

Amyloidosis, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Basal Cell, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Glioblastoma, Carcinoma, Hepatocellular, Hodgkin Disease, Lung Neoplasms, Melanoma, Multiple Myeloma, Myelodysplastic Syndromes, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Lymphoma, Mantle-Cell

NCT04691960 2025-12-19

A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging

Phase 2 Active not recruiting

Glioblastoma