Clinical Trials Browser

NCT06665724 2026-02-27

Clinical Trial Evaluating Safety of 5-Aminolevulinic Acid (5-ALA) Combined With CV01 Delivery of Ultrasound for Sonodynamic Therapy (SDT) in Patients With Newly Diagnosed High-Grade Glioma (HGG) Prior to Resection and Standard Adjuvant Therapy (ALA SDT GLIOMA 401)

Phase 1 Completed

16 enrolled

CNS

Astrocytoma, Glioblastoma, Oligodendroglioma

NCT07225621 2026-02-05

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

Phase 2 Recruiting

103 enrolled

CNS

Glioblastoma

NCT05736406 2025-09-11

A Dose-escalation Clinical Study of Intraoperative Photodynamic Therapy of Glioblastoma

Phase 1/2 Recruiting

12 enrolled

CNS

Glioblastoma, Glioma

NCT05362409 2025-06-19

Study to Evaluate 5-ALA Combined With CV01 Delivery of Ultrasound in Recurrent High Grade Glioma

Phase 1 Completed

22 enrolled

CNS

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms

NCT03897491 2025-05-14

PD L 506 for Stereotactic Interstitial Photodynamic Therapy of Newly Diagnosed Supratentorial IDH Wild-type Glioblastoma

Phase 2 Active not recruiting

20 enrolled

CNS

Glioblastoma

NCT04469699 2025-03-11

NOA11

Phase 2 Terminated

30 enrolled

CNS

Glioblastoma

NCT05590689 2024-12-16

ALA-RDTinGBM

Phase 1/2 Recruiting

34 enrolled

CNS

Glioblastoma

NCT01128218 2023-11-30

A Study of the Specificity and Sensitivity of 5- Aminolevulinic Acid (ALA) Fluorescence in Malignant Brain Tumors

Phase 1/2 Completed

33 enrolled 15 charts

CNS

Brain Neoplasms, Glioblastoma, Glioma

NCT00752323 2021-09-17

Imaging Procedure Using ALA in Finding Residual Tumor in Grade IV Malignant Astrocytoma

Phase 2 Completed

73 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00977795 2019-09-10

A Study of the Specificity and Sensitivity of 5-ALA Fluorescence in Malignant Brain Tumors

Phase 1/2 Withdrawn

CNS

Brain Neoplasms, Glioblastoma, Glioma

NCT00961090 2019-04-12

Safety Study of Aminolevulinic Acid (ALA) to Improve Visibility of Brain Tumors During Surgery

Phase 2 Completed

72 enrolled

CNS

Brain Neoplasms, Glioblastoma, Glioma

NCT01575275 2018-07-31

Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme

Phase 2 Terminated

8 enrolled 7 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01310868 2017-10-05

Gliadel Wafer and Fluorescence-Guided Surgery With 5-ALA Followed by Radiation Therapy And Temozolomide in Treating Patients With Primary Glioblastoma

Phase 2 Completed

59 enrolled 8 charts

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT01148966 2017-02-15

Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors

Phase 1 Terminated

6 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02119338 2017-01-06

5-ALA in Recurrent Glioma

Phase NA Unknown

60 enrolled

CNS

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma

NCT01445691 2016-05-17

More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery

Phase 2 Withdrawn

CNS

Brain Neoplasms, Glioblastoma, Glioma

NCT01351519 2016-03-17

A Study of Aminolevulinic Acid Used to Enhance Visualization and Surgical Removal of Brain Tumors

Phase 2 Terminated

16 enrolled

CNS

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT01798771 2013-02-26

IMAGER

Phase NA Unknown

108 enrolled

CNS

Brain Neoplasms, Glioblastoma, Glioma, Neoplasm Metastasis