Clinical Trials Browser

Phase 1 × Recruiting × Glioblastoma × Clear all

NCT04678648 2026-03-18

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

Phase 1 Recruiting

CNSGastrointestinalThoracic

Colonic Neoplasms, Glioblastoma, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Disease Progression

NCT06860594 2026-03-18

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

Phase 1 Recruiting

Astrocytoma, Glioblastoma, Lymphoma, Follicular

NCT07480941 2026-03-18

DUAL-CAR-NK-GB

Phase 1 Recruiting

Glioblastoma, Glioma

NCT04732065 2026-03-17

PNOC023

Phase 1 Recruiting

Ependymoma, Glioblastoma, Central Nervous System Neoplasms

NCT06344130 2026-03-17

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Phase 1 Recruiting

Astrocytoma, Glioblastoma, Glioma

NCT06934889 2026-03-17

Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma

Phase 1 Recruiting

Glioblastoma, Gliosarcoma

NCT06186401 2026-03-16

Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells

Phase 1 Recruiting

Glioblastoma

NCT02287428 2026-03-12

Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM

Phase 1 Recruiting

Glioblastoma

NCT03896568 2026-03-05

MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

Phase 1 Recruiting

Astrocytoma, Glioblastoma, Glioma, Gliosarcoma

NCT06917885 2026-03-05

CUE-102 in Recurrent Glioblastoma

Phase 1 Recruiting

Glioblastoma, Glioma

NCT05303467 2026-03-02

FRONTIER

Phase 1 Recruiting

Glioblastoma

NCT06641908 2026-02-18

Anti-GD2 ADC M3554 in Advanced Solid Tumors

Phase 1 Recruiting

Glioblastoma, Sarcoma

NCT03911388 2026-02-17

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Phase 1 Recruiting

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT05565118 2026-02-17

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

Phase 1 Recruiting

Glioblastoma, Glioma

NCT05660369 2026-02-04

CARv3-TEAM-E T Cells in Glioblastoma

Phase 1 Recruiting

Glioblastoma, Glioma

NCT07143812 2026-01-22

A Study to Evaluate the Safety of a Stem Cell-Based Gene and Cell Therapy in Patients With Newly Diagnosed Glioblastoma

Phase 1 Recruiting

Glioblastoma

NCT05450744 2026-01-21

IPAX-2

Phase 1 Recruiting

Glioblastoma, Neoplasms

NCT07343986 2026-01-21

BATs FUS

Phase 1 Recruiting

Glioblastoma

NCT05283330 2026-01-15

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

Phase 1 Recruiting

BreastCNSGastrointestinalGynecologicThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Colonic Neoplasms, Glioblastoma

NCT05083754 2026-01-09

Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma

Phase 1 Recruiting

Glioblastoma

NCT05106296 2026-01-09

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

Phase 1 Recruiting

Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT03423628 2025-12-22

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Phase 1 Recruiting

Brain Neoplasms, Glioblastoma, Inhibition, Psychological, Meningeal Neoplasms, Hereditary Sensory and Autonomic Neuropathies

NCT04541082 2025-12-18

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Phase 1 Recruiting

Typical Teratoid Rhabdoid Tumor, Astrocytoma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma

NCT05686798 2025-12-16

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Phase 1 Recruiting

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT07223034 2025-11-04

A Study of 177Lu-PSMA-617 in People With Gliomas

Phase 1 Recruiting

Astrocytoma, Glioblastoma, Glioma

NCT04555577 2025-10-29

Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

Phase 1 Recruiting

Glioblastoma, Gliosarcoma

NCT05789394 2025-10-27

Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy

Phase 1 Recruiting

Astrocytoma, Glioblastoma

NCT06455605 2025-10-23

D2C7-IT + 2141-V11 Combination Post-resection in rGBM

Phase 1 Recruiting

Glioblastoma

NCT05139056 2025-10-21

Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas

Phase 1 Recruiting

Glioblastoma

NCT05366179 2025-10-20

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

Phase 1 Recruiting

Brain Neoplasms, Glioblastoma, Recurrence

NCT07145112 2025-10-09

Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent Glioblastoma

Phase 1 Recruiting

Glioblastoma

NCT05557292 2025-09-19

RMC-5552 Monotherapy in Adult Subjects With Recurrent Glioblastoma

Phase 1 Recruiting

Glioblastoma

NCT07179328 2025-09-17

Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy

Phase 1 Recruiting

Brain Neoplasms, Glioblastoma, Glioma

NCT07141732 2025-09-16

Combined Treatment of Patients With Newly Diagnosed Glioblastoma Using the Xoft® Axxent® Electronic Brachytherapy (eBx®) System for Intraoperative Balloon Electronic Brachytherapy

Phase 1 Recruiting

Glioblastoma

NCT07134842 2025-08-21

WinGlio-ipi

Phase 1 Recruiting

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT06176066 2025-08-11

PH Sensitive MRI Based Resections of Glioblastoma

Phase 1 Recruiting

Glioblastoma

NCT05917145 2025-08-06

ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Treatment of Recurrent High-Grade Glioma

Phase 1 Recruiting

Glioblastoma

NCT06973096 2025-07-24

CART-EGFR-IL13Ra2 in Newly Diagnosed GBM Following Initial Radiotherapy

Phase 1 Recruiting

Glioblastoma

NCT04003649 2025-07-10

IL13Ra2-CAR T Cells With or Without Nivolumab and Ipilimumab in Treating Patients With GBM

Phase 1 Recruiting

Glioblastoma

NCT06815029 2025-06-26

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

Phase 1 Recruiting

Astrocytoma, Glioblastoma, Lymphoma, Follicular

NCT05226494 2025-06-04

Safety and Tolerability of Fb-PMT in Recurrent Glioblastoma

Phase 1 Recruiting

Glioblastoma, Glioma

NCT06902350 2025-05-25

Safety, Pharmacokinetics and Preliminary Efficacy of CS231295 in Advanced Solid Tumors

Phase 1 Recruiting

Glioblastoma, Neoplasms, Small Cell Lung Carcinoma

NCT05698524 2025-05-20

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

Phase 1 Recruiting

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT04323046 2025-05-04

Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

Phase 1 Recruiting

Glioblastoma, Glioma

NCT06632236 2025-04-25

5G-EMERALD

Phase 1 Recruiting

Glioblastoma

NCT05460507 2025-03-30

Safety & Efficacy/Tolerability of Rhenium-186 NanoLiposomes (186RNL) for Patients Who Received a Prior 186RNL Treatment

Phase 1 Recruiting

Brain Neoplasms, Glioblastoma, Glioma

NCT06039709 2024-12-09

GBM 001

Phase 1 Recruiting

Brain Neoplasms, Glioblastoma

NCT06585527 2024-10-31

Clinical Study on the Safety and Efficacy of TS-2021 in the Treatment of Recurrent Malignant Glioma

Phase 1 Recruiting

Adenoviridae Infections, Glioblastoma, Glioma

NCT06650605 2024-10-21

CITADEL-123

Phase 1 Recruiting

Glioblastoma

NCT06418113 2024-05-16

GLINERA

Phase 1 Recruiting

Brain Neoplasms, Glioblastoma