Clinical Trials Browser

NCT02359565 2026-03-18

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Familial ependymoma, Turcot syndrome, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Ependymoma, Glioma, Medulloblastoma

NCT05188508 2026-03-06

Pembrolizumab, Olaparib, and Temozolomide for People With Glioma

Phase 2 Recruiting

57 enrolled

CNS

Glioma

NCT02658279 2026-03-03

Pembrolizumab (MK-3475) in Patients With Recurrent Malignant Glioma With a Hypermutator Phenotype

Phase NA Active not recruiting

27 enrolled

CNS

Glioma

NCT04977375 2025-09-03

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

Phase 1/2 Recruiting

10 enrolled

CNS

Brain Neoplasms, Glioblastoma, Glioma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT03018288 2025-08-08

Radiation Therapy Plus Temozolomide and Pembrolizumab With and Without HSPPC-96 in Newly Diagnosed Glioblastoma (GBM)

Phase 2 Terminated

90 enrolled 24 charts

CNS

Glioblastoma, Glioma

NCT02311582 2025-05-29

MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant Gliomas

Phase 1/2 Completed

55 enrolled 14 charts

CNS

Glioma

NCT02960230 2025-01-22

H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas

Phase 1/2 Completed

50 enrolled 12 charts

CNS

Diffuse Intrinsic Pontine Glioma, Glioma

NCT06640582 2024-11-05

BAH2472

Phase 1/2 Recruiting

85 enrolled

CNS

Brain Neoplasms, Glioblastoma, Glioma, Meningioma

NCT02313272 2023-10-23

Hypofractionated Stereotactic Irradiation (HFSRT) With Pembrolizumab and Bevacizumab for Recurrent High Grade Gliomas

Phase 1 Completed

32 enrolled 12 charts

CNS

Glioma, Neoplasms, Neurologic Manifestations

NCT05366062 2022-05-13

ERC1671 to Treat Malignant Gliomas When Given in Combination With GM-CSF, Cyclophosphamide, Bevacizumab and Pembrolizumab

Phase 2 Not yet recruiting

28 enrolled

CNS

Glioma

NCT02798406 2021-07-15

CAPTIVE

Phase 2 Completed

49 enrolled

CNSSarcoma

Brain Neoplasms, Disease, Glioblastoma, Glioma, Neoplasms, Neoplasms, Nerve Tissue, Nervous System Diseases, Neuroectodermal Tumors, Neoplasms, Neuroepithelial, Gliosarcoma

NCT04220892 2020-07-31

Pilot Study of Pembrolizumab Combined With Pemetrexed or Abemaciclib for High Grade Glioma

Phase EARLY_PHASE1 Withdrawn

CNS

Glioma

NCT03311542 2018-01-10

Expanded Access for Pembrolizumab (MK-3475)

No longer available

CNSDermatologic

Glioblastoma, Glioma, Melanoma