Clinical Trials

36 enrolled

Astrocytoma, Glioblastoma, Glioma, Gliosarcoma

NCT03911388 2026-02-17

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT04991870 2026-01-23

Phase I CB-NK-TGF-ßR2-/NR3C1- in rGBM

25 enrolled

Sarcoma

Gliosarcoma

NCT06806228 2025-11-19

Phase I Pilot Study to Evaluate the Anti-glioblastoma Effect of S-Gboxin in Standard Treatment of Glioblastoma/Diffuse Midline Glioma and Response to Treatment (Regardless of Mutation Status)

Phase 1 Suspended

10 enrolled

Glioblastoma, Gliosarcoma

NCT02192359 2025-11-14

Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas

18 enrolled 16 charts

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT04555577 2025-10-29

Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

29 enrolled

Glioblastoma, Gliosarcoma

NCT02062827 2025-10-02

M032-HSV-1

29 enrolled 16 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Virus Diseases, Gliosarcoma

NCT07134842 2025-08-21

WinGlio-ipi

16 enrolled

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT06614855 2025-08-06

A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma

Astrocytoma, Glioblastoma, Gliosarcoma

NCT03452930 2025-06-04

Tinostamustine With or Without Radiation Therapy in Treating Patients With Newly Diagnosed MGMT-Unmethylated Glioblastoma

5 enrolled

Glioblastoma, Gliosarcoma

NCT05698524 2025-05-20

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT01430351 2025-05-07

Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy

144 enrolled

Glioblastoma, Gliosarcoma

NCT02186509 2025-04-30

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas

17 enrolled 11 charts

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT04397679 2025-01-15

Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma

2 enrolled

Glioblastoma, Gliosarcoma

NCT00102648 2024-10-17

Lonafarnib and Temozolomide in Treating Patients with Glioblastoma Multiforme That is Recurrent or Did Not Respond to Previous Treatment with Temozolomide

34 enrolled

Glioblastoma, Supratentorial Neoplasms, Gliosarcoma

NCT02457845 2024-01-19

HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors

13 enrolled

Choroid Plexus Carcinoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Virus Diseases, Supratentorial Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma, Rhabdoid Tumor

NCT02168270 2023-11-24

Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma

4 enrolled 6 charts

Astrocytoma, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT02658981 2023-10-06

Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18)

63 enrolled

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT02386826 2023-09-21

INC280 Combined With Bevacizumab in Patients With Glioblastoma Multiforme

CNSGastrointestinalGenitourinarySarcoma

65 enrolled

Carcinoma, Renal Cell, Glioblastoma, Colorectal Neoplasms, Gliosarcoma

NCT01257594 2023-05-25

EGFR Inhibition Using Weekly Erlotinib for Recurrent Malignant Gliomas

22 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00639639 2023-03-13

ATTAC

42 enrolled

Glioblastoma, Gliosarcoma

NCT01269424 2023-03-02

BG & TMZ Therapy of Glioblastoma Multiforme

10 enrolled

Glioblastoma, Gliosarcoma

NCT02664363 2023-02-17

ExCeL

3 enrolled 8 charts

Glioblastoma, Gliosarcoma

NCT02015819 2021-10-20

Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas

16 enrolled 16 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Gliosarcoma

NCT03020602 2021-08-10

BPM31510 in Treating Patients With Recurrent High-Grade Glioma Previously Treated With Bevacizumab

Glioblastoma, Gliosarcoma

NCT04854044 2021-05-12

ONC201 and Radiation Therapy Before Surgery for the Treatment of Recurrent Glioblastoma

Phase 1 Withdrawn

Glioblastoma, Gliosarcoma

NCT03283631 2021-04-05

INTERCEPT

2 enrolled

Glioblastoma, Glioma, Gliosarcoma

NCT00626483 2021-03-09

REGULATe

34 enrolled

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00068510 2020-08-03

Vaccine Therapy in Treating Patients With Malignant Glioma

28 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00509431 2020-07-31

Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma

19 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00498979 2020-07-24

Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers

22 enrolled

CNSDermatologicSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Melanoma, Oligodendroglioma, Glioma, Subependymal, Gliosarcoma

NCT02337426 2019-06-28

Dimethyl Fumarate, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Glioblastoma, Gliosarcoma

NCT00915694 2019-04-23

Nelfinavir Mesylate, Radiation Therapy, and Temozolomide in Treating Patients With Glioblastoma Multiforme

15 enrolled

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00002824 2019-03-13

Gene Therapy in Treating Patients With Primary Brain Tumors

Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00671801 2018-11-13

Irinotecan Plus Lenalidomide in Adult Patients With Recurrent Glioblastoma Multiforme: Phase I

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00734526 2018-11-09

Phase I Portion of Phase I/II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma

18 enrolled

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00895960 2018-11-08

Dasatinib Plus Radiation Therapy/Temozolomide in Newly-Diagnosed Glioblastoma

16 enrolled

Brain Diseases, Central Nervous System Diseases, Glioblastoma, Gliosarcoma

NCT03275558 2018-07-19

Clinical Trial of the Use of the Nasal Spray of Patients With Recurrence of Glioblastoma

Phase 1 Withdrawn

Glioblastoma, Glioma, Gliosarcoma

NCT00401024 2018-06-28

Tumor Tissue Analysis in Patients Receiving Imatinib Mesylate for Malignant Glioma

3 enrolled

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Glioma, Subependymal, Gliosarcoma

NCT00002971 2018-06-27

O(6)-Benzylguanine in Treating Patients With Malignant Glioma

Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00004041 2018-06-27

Gene Therapy in Treating Patients With Recurrent Malignant Gliomas

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00006452 2018-06-27

Gadolinium Texaphyrin Plus Radiation Therapy in Treating Patients With Supratentorial Glioblastoma Multiforme

6 enrolled

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00027625 2018-06-27

Gefitinib Plus Temozolomide in Treating Patients With Malignant Primary Glioma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00770471 2018-06-27

ABT-888, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00841555 2018-04-18

Temozolomide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Anaplastic Astrocytoma

9 enrolled 10 charts

Astrocytoma, Glioblastoma, Gliosarcoma

NCT00784914 2018-04-17

A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasm Metastasis, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT01234740 2018-04-17

Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases

7 enrolled

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT01390571 2018-02-05

Olaparib and Temozolomide in Treating Patients With Relapsed Glioblastoma

34 enrolled

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01172964 2017-11-09

A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas

15 enrolled