Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma
Phase 2/3 Completed
159 enrolled 17 charts
Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
Phase 1 Completed
17 enrolled
Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab
Phase 2 Completed
35 enrolled 13 charts
Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma
Phase 1 Completed
29 enrolled
Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas
Phase 1 Completed
46 enrolled 20 charts
Cediranib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma
Phase 1/2 Completed
46 enrolled
Ipilimumab and/or Nivolumab in Combination With Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma
Phase 1 Completed
32 enrolled
Vorinostat, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Phase 1/2 Completed
125 enrolled 12 charts
Temozolomide and Radiation Therapy With or Without Cediranib Maleate in Treating Patients With Newly Diagnosed Glioblastoma
Phase 2 Completed
261 enrolled 10 charts
Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors
Phase 2 Completed
137 enrolled 13 charts
Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Phase 1/2 Completed
79 enrolled 17 charts
Gefitinib and Radiation Therapy in Treating Patients With Glioblastoma Multiforme
Phase 1/2 Completed
158 enrolled
CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII
Phase 1/2 Completed
18 enrolled 25 charts
Dasatinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma
Phase 2 Completed
64 enrolled 12 charts
Temozolomide and Radiation Therapy With or Without Bevacizumab in Treating Patients With Newly Diagnosed Glioblastoma
Phase 3 Completed
637 enrolled 11 charts
MRI and PET/FMISO In Assessing Tumor Hypoxia in Patients With Newly Diagnosed Glioblastoma Multiforme
Phase 2 Completed
50 enrolled 16 charts
Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma
Phase 2 Completed
123 enrolled 16 charts
GW572016 to Treat Recurrent Malignant Brain Tumors
Phase 2 Completed
9 enrolled
Sorafenib Combined With Erlotinib, Tipifarnib, or Temsirolimus in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma
Phase 1/2 Completed
92 enrolled 24 charts
Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme
Phase 1/2 Completed
116 enrolled 17 charts
Motexafin Gadolinium, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
Phase 1/2 Completed
118 enrolled 10 charts
A Phase I/II Trial of BMS-247550 for Treatment of Patients With Recurrent High-Grade Gliomas
Phase 1/2 Completed
57 enrolled 18 charts
Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma
Phase 1/2 Completed
136 enrolled 27 charts
Gossypol in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme
Phase 2 Completed
56 enrolled 9 charts
Tandutinib in Treating Patients With Recurrent or Progressive Glioblastoma
Phase 1/2 Completed
60 enrolled 22 charts
Pazopanib in Treating Patients With Recurrent Glioblastoma
Phase 2 Completed
35 enrolled 12 charts
FR901228 in Treating Patients With Recurrent High-Grade Gliomas
Phase 1/2 Completed
50 enrolled 6 charts
A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas
Phase 2 Completed
112 enrolled 12 charts
Sunitinib in Treating Patients With Recurrent Malignant Gliomas
Phase 2 Completed
31 enrolled 6 charts
Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Phase 1/2 Completed
112 enrolled 14 charts
Tandutinib Plus Bevacizumab to Treat Recurrent Brain Tumors
Phase 2 Completed
42 enrolled 11 charts
RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma
Phase 1 Completed
22 enrolled
Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma
Phase 1/2 Completed
69 enrolled 12 charts
Carboxyamidotriazole + RT in Treating Patients Newly Diagnosed Supratentorial GBM
Phase 2 Completed
55 enrolled 10 charts
CC-5013 in Treating Patients With Recurrent Glioma
Phase 1 Completed
CC-8490 in Treating Patients With Recurrent or Refractory High-Grade Gliomas
Phase 1 Completed
Radiation Therapy in Treating Patients With Glioblastoma
Phase 1 Completed
34 enrolled
Chemotherapy Followed by Radiation Therapy in Treating Patients With Malignant Glioma
Phase 1 Completed
Tipifarnib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
Phase 1 Completed
19 enrolled
Cediranib Maleate and Cilengitide in Treating Patients With Progressive or Recurrent Glioblastoma
Phase 1 Completed
47 enrolled
Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors
Phase 1 Completed
20 enrolled
Sorafenib in Treating Patients With Recurrent or Progressive Malignant Glioma
Phase 1 Completed
47 enrolled
Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma
Phase 1 Completed
61 enrolled
Vorinostat in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme
Phase 2 Completed
103 enrolled 10 charts
Vorinostat and Bortezomib in Treating Patients With Progressive, Recurrent Glioblastoma Multiforme
Phase 2 Completed
44 enrolled 9 charts
Lapatinib in Treating Patients With Recurrent Glioblastoma Multiforme
Phase 1/2 Completed
24 enrolled
Combination Chemotherapy and Radiation Therapy in Treating Younger Patients Who Are Undergoing an Autologous Stem Cell Transplant for Newly Diagnosed Gliomas
Phase NA Completed
Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma
Phase 3 Completed
500 enrolled
Biological Therapy in Treating Patients With Glioblastoma Multiforme
Phase 2 Completed
40 enrolled
AZD2171 in Treating Patients With Recurrent Glioblastoma Multiforme
Phase 2 Completed
31 enrolled