Clinical Trials

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT06993844 2026-03-17

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

BreastGynecologicHead & Neck

233 enrolled

Squamous Cell Carcinoma of Head and Neck, Breast Diseases, Breast Neoplasms, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Neoplasms, Neoplasms by Site, Hereditary Sensory and Autonomic Neuropathies, Ovarian Neoplasms, Endometrial Neoplasms

NCT02439034 2026-03-16

KETOCOL

Phase 2 Completed

68 enrolled

GynecologicHead & Neck

Agnosia, Uterine Cervical Neoplasms, Head and Neck Neoplasms

NCT03485209 2026-03-16

innovaTV 207

Phase 2 Active not recruiting

352 enrolled

GastrointestinalHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT06003231 2026-03-16

A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2

Phase 2 Active not recruiting

120 enrolled

GynecologicHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms

NCT07471451 2026-03-16

RMF-CROC

Phase NA Not yet recruiting

50 enrolled

Head and Neck Neoplasms

NCT02540174 2026-03-13

ALTAKRA-1405

Phase NA Completed

133 enrolled

Head & NeckThoracic

Head and Neck Neoplasms, Lung Neoplasms, Tobacco Use

NCT03875716 2026-03-13

Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

111 enrolled

Head and Neck Neoplasms

NCT06681233 2026-03-13

Feasibility Study of CBCT for IGRT in Cancer Patients

BreastGastrointestinalHead & Neck

50 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Urogenital Neoplasms

NCT04585750 2026-03-12

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

300 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Gallbladder Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT05538533 2026-03-10

Hypofractionated Preoperative Radiation for Head and Neck Cancers (HyPR-HN)

12 enrolled

Head and Neck Neoplasms

NCT06641791 2026-03-10

Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer

Phase 3 Recruiting

196 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Head and Neck Neoplasms

NCT07459283 2026-03-10

The Safety, Dosimetry and Efficacy of 177Lu-INN805 in Patients With Malignant Solid Tumors

10 enrolled

BreastHead & NeckSarcoma

Breast Neoplasms, Head and Neck Neoplasms, Sarcoma, Thyroid Neoplasms

NCT07460765 2026-03-10

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

Phase 1 Not yet recruiting

40 enrolled

Phase 1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Neoplasms, Squamous Cell

NCT07462377 2026-03-10

A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

110 enrolled

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms

NCT04915183 2026-03-09

Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer

224 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hearing Loss

NCT06636188 2026-03-09

Digi-Coach

138 enrolled

Head and Neck Neoplasms

NCT07209189 2026-03-09

(NeoScorch HN)

75 enrolled

Phase 2 Active not recruiting

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT02568267 2026-03-06

STARTRK-2

534 enrolled 1 FDA

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidNETSarcomaThoracic

Thyroid Cancer, Papillary, Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Colorectal Neoplasms, Lymphoma, Large-Cell, Anaplastic, Cholangiocarcinoma, Neuroendocrine Tumors

NCT06674499 2026-03-06

Development and Evaluation of a Self-Management Model for Cancer Rehabilitation

144 enrolled

Head and Neck Neoplasms

NCT04222972 2026-03-05

AcceleRET-Lung

Phase 3 Terminated

223 enrolled 18 charts

Head & NeckThoracic

Adenocarcinoma, Bronchial Diseases, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms

NCT06627270 2026-03-05

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Mouth Neoplasms

NCT04541381 2026-03-04

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

BreastGastrointestinalHead & Neck

860 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Dihydropyrimidine Dehydrogenase Deficiency

NCT05108870 2026-03-04

TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers

98 enrolled

Head and Neck Neoplasms

NCT05570851 2026-03-04

Alcohol Cessation Among Head and Neck Cancer Survivors

138 enrolled

Alcohol Drinking, Depression, Head and Neck Neoplasms, Social Isolation, Substance-Related Disorders

NCT06091930 2026-03-04

A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6

GastrointestinalHead & NeckThoracic

97 enrolled

Gastrointestinal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT07020117 2026-03-04

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

BreastHead & NeckThoracic

150 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Triple Negative Breast Neoplasms

NCT07065630 2026-03-04

Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer

38 enrolled

Head and Neck Neoplasms

NCT06208826 2026-03-03

A Single-center Phase II Study to Investigate the Immune Maintenance Therapy Pattern in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Achieved MPR After Neoadjuvant Immunotherapy Combined With Chemotherapy

268 enrolled

Head and Neck Neoplasms

NCT06657222 2026-03-03

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

250 enrolled

BreastHead & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Triple Negative Breast Neoplasms

NCT07217938 2026-03-03

TRADstat

48 enrolled

Deglutition Disorders, Head and Neck Neoplasms

NCT07447050 2026-03-03

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

BreastGastrointestinalGynecologicHead & NeckSarcomaThoracic

24 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms, Urogenital Neoplasms, Colorectal Neoplasms

NCT07447570 2026-03-03

Iparomlimab and Tuvonralimab Plus Hypofractionated Radiotherapy and Chemotherapy for HAHNSCC

27 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05388136 2026-03-02

DeintensiF

Phase NA Terminated

30 enrolled

Head and Neck Neoplasms

NCT05768139 2026-03-02

PIKALO-1

BreastGynecologicHead & Neck

720 enrolled

Squamous Cell Carcinoma of Head and Neck, Breast Diseases, Breast Neoplasms, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Neoplasms, Neoplasms by Site, Hereditary Sensory and Autonomic Neuropathies, Ovarian Neoplasms, Endometrial Neoplasms

NCT06910657 2026-03-02

IDOV-Immune for Advanced Solid Tumors

BreastDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

78 enrolled

Adrenal Gland Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Vaccinia, Colorectal Neoplasms

NCT00003809 2026-02-27

Cisplatin With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic or Recurrent Head and Neck Cancer

Phase 3 Completed

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02589938 2026-02-27

ACUPUNCTURE

Phase NA Completed

258 enrolled 16 charts

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Radiation Injuries, Salivary Gland Neoplasms, Xerostomia

NCT06239220 2026-02-27

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

25 enrolled

Phase EARLY_PHASE1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07435415 2026-02-27

Local Injection Methylene Blue Combined With Radiation in HNSCC Patients

10 enrolled

Head and Neck Neoplasms

NCT05898789 2026-02-25

Virtual Rehabilitation for Cancer Survivors

BreastGastrointestinalHead & NeckLymphoid

388 enrolled

Breast Carcinoma In Situ, Breast Neoplasms, Head and Neck Neoplasms, Lymphoma, Lymphoproliferative Disorders, Colorectal Neoplasms

NCT07431099 2026-02-25

RECOLOR-HN

Phase NA Not yet recruiting

20 enrolled

Head and Neck Neoplasms

NCT07101432 2026-02-24

Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)

33 enrolled

Head and Neck Neoplasms

NCT07419113 2026-02-24

UNOS

Phase NA Completed

45 enrolled

Phase NA Not yet recruiting

Head and Neck Neoplasms

NCT07431346 2026-02-24

DYSGRAD

80 enrolled

Dysgeusia, Head and Neck Neoplasms

NCT04713449 2026-02-23

Enhancing Self Care Among Oral Cancer Survivors: The Empowered Survival Trial

643 enrolled

Head and Neck Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT06525220 2026-02-23

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

Phase 3 Recruiting

500 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Diseases

NCT07426874 2026-02-23

eHealth Support Tool to Improve Quality of Life in Head and Neck Cancer Survivors

30 enrolled

Head and Neck Neoplasms

NCT04258813 2026-02-20

ONE TEAM