Clinical Trials

75 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT04222972 2026-03-05

AcceleRET-Lung

Phase 3 Terminated

223 enrolled 18 charts

Head & NeckThoracic

Adenocarcinoma, Bronchial Diseases, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms

NCT05108870 2026-03-04

TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers

Phase 1/2 Recruiting

98 enrolled

Head and Neck Neoplasms

NCT07065630 2026-03-04

Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer

38 enrolled

Head and Neck Neoplasms

NCT04858269 2026-01-28

First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients

32 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT05420948 2025-12-22

A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer

30 enrolled

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT01154920 2025-12-17

Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma

128 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03358472 2025-12-03

Pembrolizumab Plus Epacadostat, Pembrolizumab Monotherapy, and the EXTREME Regimen in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (KEYNOTE-669/ECHO-304)

Phase 3 Completed

89 enrolled 14 charts

BreastGastrointestinalGenitourinaryGynecologicHead & Neck

Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04954599 2025-10-07

Phase 1/2 Clinical Trial of CP-506 (HAP) in Monotherapy or With Carboplatin or ICI

Phase 1/2 Recruiting

126 enrolled

Head and Neck Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Triple Negative Breast Neoplasms

NCT04722523 2025-09-23

A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer

Phase 1 Recruiting

40 enrolled

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04675333 2025-08-03

Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)

172 enrolled

882 enrolled 50 charts 1 FDA

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02358031 2025-07-18

MK-3475-048

Phase 3 Completed

Parkinson Disease 4, Autosomal Dominant Lewy Body, Head and Neck Neoplasms

NCT06940180 2025-06-26

Toripalimab With Chemotherapy for Sinus Cancer

20 enrolled

Sinonasal undifferentiated carcinoma, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Paranasal Sinus Neoplasms

NCT05726370 2025-06-22

Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC

28 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05388773 2025-06-19

Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

150 enrolled

Phase 1 Active not recruiting

Carcinoma, Squamous Cell, DNA Virus Infections, Head and Neck Neoplasms, Stomatognathic Diseases, Neoplasms, Glandular and Epithelial, Oropharyngeal Neoplasms, Otorhinolaryngologic Diseases, Otorhinolaryngologic Neoplasms, Papilloma, Pharyngeal Diseases, Pharyngeal Neoplasms, Tumor Virus Infections, Papillomavirus Infections

NCT06110195 2025-06-08

Study of Xevinapant With Radiation and Chemotherapy for Patients With Head and Neck Cancer

42 enrolled

Phase 1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05704985 2025-05-29

Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors

39 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Kidney Neoplasms, Neoplasms, Pancreatic Neoplasms, Skin Neoplasms, Colorectal Neoplasms

NCT04999761 2024-09-25

AB122 Platform Study

Phase 1 Recruiting

917 enrolled

GastrointestinalHead & NeckSarcomaThoracic

Biliary Tract Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Neoplasm Metastasis, Stomach Neoplasms, Colorectal Neoplasms, Sarcoma, Alveolar Soft Part

NCT06366945 2024-04-16

Tirelizumab in Combination With Carboplatin and Polymeric Micellar Paclitaxel for Neoadjuvant Therapy in cN+ HNSCC

Phase 2 Not yet recruiting

85 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05358548 2024-04-10

ATATcH Alternating Treatment Plans for Advanced Cancer

150 enrolled

Head & NeckThoracic

Head and Neck Neoplasms, Lung Neoplasms

NCT01437449 2024-01-30

Docetaxel, Cisplatin, and Cetuximab (TPC) in Palliative Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck (SCCHN)

27 enrolled 13 charts

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Head and Neck Neoplasms

NCT02897375 2023-10-10

Palbociclib With Cisplatin or Carboplatin in Advanced Solid Tumors

Phase 1 Completed

71 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Sarcoma, Colorectal Neoplasms

NCT06062602 2023-10-06

PBI-MST-01(NCT04541108) Substudy TAK-02: Intratumoral Microdosing of TAK-676 in HNSCC

Phase EARLY_PHASE1 Completed

15 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02741570 2023-09-21

CheckMate 651

Phase 3 Completed

947 enrolled 19 charts

Head and Neck Neoplasms

NCT00079079 2023-08-04

Cisplatin or Carboplatin Combined With Gemcitabine in Locally Advanced, Recurrent, or Metastatic Malignant Salivary Gland Tumor

34 enrolled

Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT04572100 2023-07-07

Pilot Study of Chemotherapy for HPV-Associated Oropharyngeal Cancer

Phase 1 Completed

50 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00089297 2023-06-29

Cetuximab, Chemotherapy, and Radiation Therapy for Operable Stage III or IV Head and Neck Cancer

74 enrolled 8 charts

Head and Neck Neoplasms

NCT02760667 2023-06-27

Induction Chemotherapy Followed by Surgery for Locally Advanced Head and Neck Cancer

Phase 2 Unknown

20 enrolled

Head and Neck Neoplasms, Laryngeal Neoplasms, Oropharyngeal Neoplasms

NCT00003206 2023-06-15

Carboplatin and Paclitaxel in Treating Patients With Locally Recurrent or Metastatic Nasopharyngeal Cancer

Head and Neck Neoplasms, Nasopharyngeal Neoplasms

NCT00014118 2023-06-15

Chemotherapy and Radiation Therapy in Treating Patients With Stage III or Stage IV Larynx or Oropharynx Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00997906 2022-09-29

Cisplatin and RT With or Without Gemcitabine, Carboplatin, and Paclitaxel in Treating Patients With Locally Advanced NPC

Phase 2/3 Unknown

172 enrolled

Head and Neck Neoplasms

NCT01716195 2021-02-26

Induction Chemotherapy Followed by Chemoradiotherapy for Head and Neck Cancer

18 enrolled 10 charts

Head and Neck Neoplasms

NCT01412229 2020-11-23

Induction Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck

40 enrolled 14 charts

Head and Neck Neoplasms

NCT01020864 2020-11-02

CECAVI

Phase 2 Withdrawn

Head and Neck Neoplasms

NCT02124707 2020-08-12

Weekly Carboplatin, Paclitaxel and Cetuximab Treatment for Patients With Recurrent or Metastatic SCCHN

14 enrolled 17 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasm Metastasis, Recurrence

NCT03342352 2019-12-20

Nivolumab Plus Epacadostat in Combination With Chemotherapy Versus the EXTREME Regimen in Squamous Cell Carcinoma of the Head and Neck (CheckMate 9NA/ECHO-310)

Phase 3 Withdrawn

Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT01063075 2019-09-26

A Study in Advanced Solid Tumors

34 enrolled 15 charts

Head & NeckSarcoma

Carcinoma, Head and Neck Neoplasms, Sarcoma

NCT00343083 2019-08-19

Evaluation of Cetuximab (ERBITUX) and Concurrent Carboplatin, Paclitaxel & Radiotherapy in the Management of Patients With Advanced Locoregional Squamous Cell Carcinomas of the Head and Neck (GCC 0442)

43 enrolled 11 charts

Head and Neck Neoplasms

NCT01016769 2019-06-26

Temsirolimus + Weekly Paclitaxel + Carboplatin for Recurrent or Metastatic Head and Neck Squamous Cell Cancer (HNSCC)

Phase 1/2 Completed

48 enrolled 15 charts

Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT03386838 2019-04-18

An Immuno-therapy Study of Nivolumab in Combination With Experimental Medication BMS-986205 Compared to Standard of Care EXTREME Regimen in First-line Recurrent/Metastatic Squamous Cell Carcinoma of Head and Neck

Phase 3 Withdrawn

Head and Neck Neoplasms

NCT02633800 2019-01-07

Patritumab With Cetuximab and a Platinum Agent for Squamous Cell Carcinoma (Cancer) of the Head and Neck (SCCHN )

Phase 2 Terminated

87 enrolled 13 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasms by Site

NCT03637335 2018-08-20

METAXIOM

Phase 3 Terminated

26 enrolled

Head & NeckThoracic

Head and Neck Neoplasms, Lung Neoplasms, Neoplasm Metastasis

NCT01009346 2018-07-17

RAD001 in Combination With Cetuximab and Cisplatin in Recurrent and Metastatic SCCHN

Phase 1/2 Terminated

9 enrolled 9 charts

Head and Neck Neoplasms

NCT00498953 2018-07-09

Combination Chemotherapy and Radiation Therapy With or Without Lapatinib in Treating Patients With Locally Advanced Cancer of the Larynx or Hypopharynx

Phase 1/2 Completed

7 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00646659 2018-07-09

Cetuximab, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Head and Neck Cancer That Cannot Be Removed By Surgery

Phase 2 Terminated

47 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00704639 2017-07-12

Chemoradiation Treatment for Head and Neck Cancer

Phase 1/2 Completed

60 enrolled

Head and Neck Neoplasms

NCT01911598 2017-07-06

A Study of MEHD7945A in Combination With Cisplatin and 5-Fluorouracil (5-FU) or Paclitaxel and Carboplatin in Participants With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (R/M SCCHN)

Phase 1 Completed

24 enrolled

Head and Neck Neoplasms

NCT00270790 2017-02-01

EVALUATION OF AMIFOSTINE FOR MUCOSAL AND HEMOPOETIC PROTECTION AND CARBOPLATIN, TAXOL, RADIOTHERAPY IN THE MANAGEMENT OF PATIENTS WITH HEAD AND NECK CANCER.(GCC 0202)

21 enrolled 6 charts