Clinical Trials

Phase 1/2 Active not recruiting

Head and Neck Neoplasms

NCT06237881 2026-02-18

A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors

15 enrolled

DermatologicHead & NeckThoracic

Head and Neck Neoplasms, Lung Neoplasms, Melanoma

NCT03777384 2026-02-06

EValuating the Safety Of De-escaLated Head and Neck Irradiation in HPV positivE Oropharynx Cancer in Non-smokers/Minimal Smokers

75 enrolled

Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT05325970 2026-02-06

ORARAD II

350 enrolled

Head and Neck Neoplasms, Stomatognathic Diseases, Neoplasms, Osteoradionecrosis

NCT05980000 2026-02-06

Rambro2

37 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07394842 2026-02-06

HN-ORAL-RT

100 enrolled

Squamous Cell Carcinoma of Head and Neck, Dental Caries, Head and Neck Neoplasms, Periodontal Diseases, Xerostomia

NCT03968679 2026-02-04

SUSPECT-2

90 enrolled

Head and Neck Neoplasms

NCT06137274 2026-01-29

Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC

25 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT02919683 2026-01-28

Window Study of Nivolumab With or Without Ipilimumab in Squamous Cell Carcinoma of the Oral Cavity

30 enrolled 14 charts

Head and Neck Neoplasms

NCT03210103 2026-01-28

ORATOR2

61 enrolled

Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT04208490 2026-01-23

HN-STAR

357 enrolled

Head and Neck Neoplasms

NCT04251481 2026-01-22

Diffusion MRI for Head and Neck Cancer

16 enrolled

Head and Neck Neoplasms

NCT04617678 2026-01-16

A Comprehensive Approach to Head and Neck Cancer Prehabilitation

80 enrolled

Head and Neck Neoplasms

NCT05671861 2026-01-13

Evaluating a Low-Cost Therapeutic Device in Managing Head and Neck Cancer Patients With Radiation-Related Trismus

35 enrolled

Head and Neck Neoplasms, Trismus

NCT07334938 2026-01-13

Effects of Far Infrared Rays and Transcutaneous Electrical Nerve Stimulation on Short Term Prognosis of Head and Neck Cancer Patients Receiving Curative Treatment

90 enrolled

Head and Neck Neoplasms

NCT02724488 2026-01-08

SPECIAL

14 enrolled

DermatologicHead & Neck

Head and Neck Neoplasms, Melanoma

NCT04124198 2025-12-31

QoLATI

138 enrolled

Phase 1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Carcinoma, Squamous Cell, DNA Virus Infections, Head and Neck Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Oropharyngeal Neoplasms, Otorhinolaryngologic Diseases, Otorhinolaryngologic Neoplasms, Pharyngeal Diseases, Tumor Virus Infections, Virus Diseases, Neoplasms, Squamous Cell, Papillomavirus Infections

NCT05327270 2025-12-26

Non-randomized, Open-label Study of Intralesional Nivolumab for High Risk Oral Premalignant Lesions

18 enrolled

Head and Neck Neoplasms

NCT01154920 2025-12-17

Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma

128 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03224000 2025-12-17

Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer

90 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT03347838 2025-12-12

Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers

Head & NeckOther neoplasm

19 enrolled 10 charts

Tobacco Smoking, Head and Neck Neoplasms, Precancerous Conditions

NCT03506451 2025-12-04

PaRTNer

60 enrolled

Financial Stress, Head and Neck Neoplasms

NCT05207098 2025-12-04

A Study of Neurocognitive Tests and Questionnaires for People With Head and Neck Cancer Who Are Undergoing Radiation Therapy

54 enrolled

Phase EARLY_PHASE1 Active not recruiting

Head and Neck Neoplasms

NCT01098955 2025-11-10

Smoking Cessation Treatment for Head & Neck Cancer Patients

51 enrolled

Head and Neck Neoplasms, Neoplasms, Smoking Cessation

NCT03491176 2025-11-10

Magnetic Resonance (MR) Imaging & Blood Biomarkers for Head and Neck Cancer

100 enrolled

Head and Neck Neoplasms

NCT02253238 2025-11-06

Sensor-Assisted Prevention of Dehydration in Head and Neck Cancer Patients

427 enrolled

Dehydration, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms

NCT03114501 2025-11-03

Dyadic Yoga Intervention for Patient With Head and Neck Cancer Undergoing Radiotherapy and Their Family Caregivers

236 enrolled

Phase 3 Active not recruiting

Head and Neck Neoplasms

NCT01266044 2025-10-27

Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia

435 enrolled

Head and Neck Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT02662907 2025-10-27

Cough, Expiratory Training, and Chronic Aspiration After Head and Neck Radiotherapy

175 enrolled

Head and Neck Neoplasms

NCT02994069 2025-10-14

Cisplatin + Radiation in SCCHN and Correlation With Oxidative Stress Markers

80 enrolled 11 charts

Carcinoma, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT05036330 2025-10-14

ProvoxLife Adoption Trends for Heat-Moisture Exchanger

130 enrolled

Head and Neck Neoplasms

NCT02841748 2025-10-01

A Randomized, Double-Blind Phase II Study of Adjuvant Pembrolizumab Versus Placebo in Head and Neck Cancers at High Risk for Recurrence- the PATHWay Study

100 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05252429 2025-09-12

Docetaxel/Pembrolizumab in Head and Neck Squamous Cell Carcinoma

27 enrolled

Head and Neck Neoplasms

NCT05091190 2025-09-11

MADMAS

75 enrolled

Head & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms

NCT05997329 2025-09-08

NUTREAT

125 enrolled

Phase EARLY_PHASE1 Active not recruiting

Head and Neck Neoplasms

NCT05816785 2025-09-03

Pilot Study of Imatinib Cetuximab Combo for H & N Cancer

15 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06145412 2025-08-24

A Study of Xevinapant With Cisplatin and Radiation Therapy After Surgery in People With Head and Neck Cancer

4 enrolled

Head and Neck Neoplasms

NCT06384417 2025-08-08

Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning: Phase 2

BreastDermatologicGastrointestinalHead & NeckThoracic

32 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Urogenital Neoplasms, Colorectal Neoplasms

NCT03217188 2025-08-06

Proton Re-Irradiation for Recurrent Head and Neck Cancer

87 enrolled

Head and Neck Neoplasms

NCT04609280 2025-07-29

SAVER

52 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT04373642 2025-07-24

QUADSHOT

30 enrolled

Phase 1 Active not recruiting

Head and Neck Neoplasms

NCT05540899 2025-07-24

Testing the Safety of Giving a Standard Dose of Radiation Over a Shorter Period of Time for Patients Who Had Surgery for Intermediate-Risk Head and Neck Cancer

14 enrolled