Clinical Trials

111 enrolled

Head and Neck Neoplasms

NCT06681233 2026-03-13

Feasibility Study of CBCT for IGRT in Cancer Patients

BreastGastrointestinalHead & Neck

50 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Urogenital Neoplasms

NCT04585750 2026-03-12

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

300 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Gallbladder Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT06641791 2026-03-10

Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer

Phase 3 Recruiting

196 enrolled

Head and Neck Neoplasms

NCT04915183 2026-03-09

Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer

224 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hearing Loss

NCT06636188 2026-03-09

Digi-Coach

138 enrolled

Head and Neck Neoplasms

NCT07209189 2026-03-09

(NeoScorch HN)

75 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT06627270 2026-03-05

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Mouth Neoplasms

NCT04541381 2026-03-04

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

BreastGastrointestinalHead & Neck

860 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Dihydropyrimidine Dehydrogenase Deficiency

NCT05108870 2026-03-04

TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers

98 enrolled

Head and Neck Neoplasms

NCT06091930 2026-03-04

A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6

97 enrolled

Gastrointestinal Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT07020117 2026-03-04

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

BreastHead & NeckThoracic

150 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Triple Negative Breast Neoplasms

NCT07065630 2026-03-04

Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer

38 enrolled

Head and Neck Neoplasms

NCT06208826 2026-03-03

A Single-center Phase II Study to Investigate the Immune Maintenance Therapy Pattern in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Achieved MPR After Neoadjuvant Immunotherapy Combined With Chemotherapy

268 enrolled

Head and Neck Neoplasms

NCT06657222 2026-03-03

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

250 enrolled

BreastHead & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Triple Negative Breast Neoplasms

NCT07217938 2026-03-03

TRADstat

48 enrolled

Deglutition Disorders, Head and Neck Neoplasms

NCT07447050 2026-03-03

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

BreastGastrointestinalGynecologicHead & NeckSarcomaThoracic

24 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms, Urogenital Neoplasms, Colorectal Neoplasms

NCT07447570 2026-03-03

Iparomlimab and Tuvonralimab Plus Hypofractionated Radiotherapy and Chemotherapy for HAHNSCC

27 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05768139 2026-03-02

PIKALO-1

BreastGynecologicHead & Neck

720 enrolled

Squamous Cell Carcinoma of Head and Neck, Breast Diseases, Breast Neoplasms, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Neoplasms, Neoplasms by Site, Hereditary Sensory and Autonomic Neuropathies, Ovarian Neoplasms, Endometrial Neoplasms

NCT06910657 2026-03-02

IDOV-Immune for Advanced Solid Tumors

BreastDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

78 enrolled

Adrenal Gland Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Vaccinia, Colorectal Neoplasms

NCT06239220 2026-02-27

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

25 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05898789 2026-02-25

Virtual Rehabilitation for Cancer Survivors

BreastGastrointestinalHead & NeckLymphoid

388 enrolled

Breast Carcinoma In Situ, Breast Neoplasms, Head and Neck Neoplasms, Lymphoma, Lymphoproliferative Disorders, Colorectal Neoplasms

NCT07101432 2026-02-24

Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)

33 enrolled

Head and Neck Neoplasms

NCT06525220 2026-02-23

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

Phase 3 Recruiting

500 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Diseases

NCT05647122 2026-02-20

EGRET

403 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Neoplasms, Colorectal Neoplasms

NCT04485013 2026-02-18

TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

240 enrolled

Adenocarcinoma of Lung, Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT07085091 2026-02-17

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

170 enrolled

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Head and Neck Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT07110142 2026-02-13

T-PROSE

40 enrolled

Head and Neck Neoplasms, Mouth Neoplasms

NCT04534205 2026-02-12

AHEAD-MERIT

Phase 2/3 Recruiting

350 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasm Metastasis, Recurrence

NCT07405645 2026-02-12

MRg-FUS

20 enrolled

Cancer Pain, Head and Neck Neoplasms

NCT04930432 2026-02-10

Study of MCLA-129, a Human Bispecific EGFR and cMet Antibody, in Patients With Advanced NSCLC and Other Solid Tumors

400 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Colorectal Neoplasms

NCT05787587 2026-02-09

A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicHead & Neck

216 enrolled

Mental Retardation, X-Linked, With Or Without Seizures, Arx-Related, Breast Neoplasms, Head and Neck Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT06289049 2026-02-09

LIFTING2

60 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Motor Activity

NCT04916990 2026-02-05

Improving Care for Rural Patients With Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

320 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Rectal Neoplasms, Thyroid Neoplasms

NCT05962242 2026-02-05

HN001

90 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06531083 2026-02-05

PRECISE

30 enrolled

Head and Neck Neoplasms, Trismus

NCT03017573 2026-02-03

SCANDARE

BreastGynecologicHead & NeckSarcoma

1,050 enrolled

Uterine Cervical Neoplasms, Head and Neck Neoplasms, Ovarian Neoplasms, Sarcoma, Vulvar Neoplasms, Triple Negative Breast Neoplasms

NCT07278557 2026-02-03

Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia

98 enrolled

Head and Neck Neoplasms

NCT06319963 2026-02-02

A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer

72 enrolled

GynecologicHead & Neck

Uterine Cervical Neoplasms, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT04389281 2026-01-30

X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma

52 enrolled

Phase EARLY_PHASE1 Recruiting

Head and Neck Neoplasms

NCT06639191 2026-01-30

AKIR001

15 enrolled

EndocrineGynecologicHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Vulvar Neoplasms, Thyroid Carcinoma, Anaplastic

NCT04858269 2026-01-28

First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients

32 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT06172478 2026-01-28

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

740 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Endometrial Neoplasms

NCT05553782 2026-01-26

Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers

Phase EARLY_PHASE1 Recruiting

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT07358806 2026-01-22

Study to Assess the Effect of OCT-598 in Patients With Advanced Solid Tumors

BreastGenitourinaryHead & NeckThoracic

51 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Prostatic Neoplasms

NCT06297902 2026-01-21

RADPAINT-3

100 enrolled

Head and Neck Neoplasms, Radiation Injuries

NCT06837480 2026-01-21

Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema

150 enrolled

Head and Neck Neoplasms

NCT07292168 2026-01-21

TAGNOT

BreastGenitourinaryHead & NeckThoracic

58 enrolled

Acrocephalosyndactylia, Breast Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Prostatic Neoplasms

NCT06607406 2026-01-20

Postoperative Radiotherapy for Intermediate- and High-risk Patients With HNSCC Greater Than 6 Weeks After Surgery

75 enrolled