Clinical Trials

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Diseases

NCT05199584 2026-03-05

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

CNSDermatologicEndocrineHead & NeckOther solid neoplasmSarcomaThoracic

20 enrolled

Uveal Melanoma, Glioma, Adenoma, Islet Cell, Laryngeal Diseases, Medulloblastoma, Melanoma, Mesothelioma, Neuroblastoma, Pituitary Diseases, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma

NCT06525220 2026-02-23

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

Phase 3 Recruiting

500 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Diseases

NCT03656133 2026-02-20

Use of a Proliferation Saturation Index to Determine Personalized Radiotherapy for HPV + Oropharyngeal Cancers

55 enrolled 10 charts

Laryngeal Diseases, Oropharyngeal Neoplasms

NCT05386550 2026-02-19

Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION)

Phase 3 Terminated

166 enrolled 15 charts

Phase 2 Not yet recruiting

Head and Neck Neoplasms, Laryngeal Diseases

NCT07419464 2026-02-19

5-Fluorouracil Response and Optimization STudy (The FROST Trial)

46 enrolled

BreastGastrointestinalGenitourinaryHead & NeckLymphoid

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases

NCT04368702 2026-02-09

CONFIRM

Phase NA Recruiting

70 enrolled

Breast Carcinoma In Situ, Urinary Bladder Neoplasms, Laryngeal Diseases, Laryngeal Neoplasms, Lymphoma, Stomach Neoplasms, Lymphoma, Mantle-Cell

NCT00576134 2025-12-22

The Objective is to Respond to Patients' Needs in the Field of Larynx Replacement

10 enrolled

GastrointestinalHead & NeckOther solid neoplasmThoracic

Deglutition Disorders, Laryngeal Diseases, Laryngeal Neoplasms

NCT03556228 2025-12-11

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

Phase 1/2 Recruiting

242 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Adenoid Cystic, Esophageal Neoplasms, Head and Neck Neoplasms, Laryngeal Diseases, Lung Neoplasms, Mesothelioma, Neoplasm Metastasis, Pancreatic Neoplasms, Salivary Gland Neoplasms, Tracheal Diseases, Small Cell Lung Carcinoma

NCT06080503 2025-11-26

G-FORCE

Phase NA Recruiting

67 enrolled

Laryngeal Diseases, Laryngeal Neoplasms

NCT02586207 2025-10-07

Pembrolizumab in Combination With CRT for LA-SCCHN

59 enrolled 9 charts

Phase EARLY_PHASE1 Recruiting

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Diseases, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT06819228 2025-10-03

Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer

18 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Mouth Neoplasms, Tongue Neoplasms

NCT06915454 2025-10-03

High-Resolution PET-CT Imaging for Surgical Margin Visualization

Phase NA Recruiting

50 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Mouth Neoplasms, Neoplasms, Tongue Neoplasms

NCT06056310 2025-09-29

Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX)

Phase 1 Terminated

18 enrolled 9 charts

Phase NA Not yet recruiting

Head and Neck Neoplasms, Laryngeal Diseases

NCT06078527 2025-07-23

Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort

40 enrolled

Phase 2 Active not recruiting

Globus Sensation, Laryngeal Diseases, Vocal Cord Paralysis, Dysphonia

NCT03529422 2025-07-20

Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN

18 enrolled 10 charts

Phase 2 Active not recruiting

Lymphoid Interstitial Pneumonia, Laryngeal Diseases, Mouth Neoplasms

NCT03854032 2025-06-06

Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck

45 enrolled

Phase EARLY_PHASE1 Completed

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases

NCT03109873 2025-04-30

Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer

9 enrolled 6 charts

Phase EARLY_PHASE1 Completed

Lymphoid Interstitial Pneumonia, Laryngeal Diseases

NCT03162731 2025-04-29

Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage III-IVB Head and Neck Cancer

24 enrolled

Lymphoid Interstitial Pneumonia, Laryngeal Diseases

NCT02128906 2025-03-26

Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design

Phase 2 Recruiting

120 enrolled

Carcinoma, Squamous Cell, Laryngeal Diseases

NCT05784012 2025-03-13

RADIAN

Phase 1/2 Recruiting

34 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT01693718 2024-01-29

A Multicenter Study of Intensive Concomitant Chemoradiotherapy With Filgrastim (GCSF) for Patients With Locoregionally Advanced Head and Neck Cancer

44 enrolled

Laryngeal Diseases, Neoplasms

NCT01185158 2023-11-29

A Phase II Study of 250-mg ZD1839 Monotherapy in Recurrent or Metastatic or Both Recurrent and Metastatic Squamous Cell Carcinoma

46 enrolled

Lymphoid Interstitial Pneumonia, Head and Neck Neoplasms, Laryngeal Diseases

NCT02892487 2023-11-18

RORC

Phase NA Terminated

183 enrolled

Deglutition Disorders, Head and Neck Neoplasms, Laryngeal Diseases

NCT01185171 2023-05-11

Trial of Induction Chemotherapy With Carboplatin and Paclitaxel, Followed by Concurrent Chemotherapy/Radiation Therapy With ZD1839 (IRESSA), 5-FU, Hydroxyurea, and Twice-Daily Radiation, Followed by Adjuvant ZD1839 Monotherapy in Patients With Locally Advanced Head & Neck Cancer

70 enrolled 11 charts

Lymphoid Interstitial Pneumonia, Head and Neck Neoplasms, Laryngeal Diseases

NCT03737968 2023-03-21

Window of Opportunity Trial of Durvalumab (MEDI4736) or Durvalumab/Tremelimumab as Neoadjuvant Chemotherapy to Identify Immune Dynamics in Surgically Resectable Head and Neck Cancer Patients.

Phase 2 Unknown

48 enrolled

Laryngeal Diseases

NCT02126969 2023-03-13

A Study of Chemo +/- Low-dose Radiation as Induction Therapy in SCCHN

45 enrolled 13 charts

Head and Neck Neoplasms, Laryngeal Diseases, Neoplasms

NCT02158234 2023-01-19

Stereotactic Body Radiotherapy and Concurrent Cisplatin for Re-Irradiation of Unresectable, Recurrent Squamous Cell Carcinomas of Head and Neck

20 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases

NCT05679856 2023-01-11

VC-Larynx

Phase NA Unknown

50 enrolled

Laryngeal Diseases, Laryngeal Neoplasms

NCT01884259 2022-05-26

HNO-2

100 enrolled

Squamous Cell Carcinoma of Head and Neck, Laryngeal Diseases

NCT00198328 2022-03-04

Medpulser Electroporation With Bleomycin Study to Treat Posterior Head and Neck Squamous Cell Carcinoma

Phase 3 Terminated

84 enrolled

Carcinoma, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Neoplasms

NCT01326923 2020-10-09

Induction Chemo Then Concurrent Chemoradiotherapy With Cetuximab in Locally Advanced Head and Neck Squamous Cell Cancer

Phase 2 Terminated

7 enrolled 5 charts

Laryngeal Diseases

NCT00534729 2019-03-01

Organ Preservation: Weekly Carboplatin & Taxol w/Concurrent RT for Locally Advanced Laryngeal & Hypopharyngeal CA

200 enrolled

GastrointestinalHead & Neck

Hypopharyngeal Neoplasms, Laryngeal Diseases, Laryngeal Neoplasms

NCT02205398 2019-01-22

Study of Safety and Efficacy of INC280 and Cetuximab, in Adult c-MET Positive mCRC and HNSCC Patients After Progression on Cetuximab or Panitumumab Therapy

Phase 1 Terminated

13 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02035735 2018-12-11

Interest of Narrow Band Imaging in Detection of Upper Aerodigestive Cancers

93 enrolled

Margins of Excision, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases

NCT01540682 2018-08-29

MLN8237 in Head and Neck Cancer

9 enrolled

Head and Neck Neoplasms, Laryngeal Diseases

NCT02926573 2018-08-08

GABA

Phase 4 Completed

123 enrolled 13 charts

Head and Neck Neoplasms, Laryngeal Diseases, Pain, Postoperative, Acute Pain

NCT02540928 2018-07-18

AMG 319 in HPV Positive and Negative HNSCC

Phase 2 Terminated

35 enrolled

Squamous Cell Carcinoma of Head and Neck, Laryngeal Diseases

NCT01456143 2018-02-01

Optical Imaging of Head and Neck Cancer

Phase NA Terminated

33 enrolled 9 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Neoplasms

NCT01733823 2017-07-28

DAHANCA 28A: Phase I/II Study on Accelerated, Hyperfractionated Radiotherapy With Concomitant Cisplatin and Nimorazole

Phase 1/2 Completed

31 enrolled

Squamous Cell Carcinoma of Head and Neck, Laryngeal Diseases

NCT00101582 2016-09-27

Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer

Phase 3 Completed

188 enrolled 19 charts

Head & NeckOther

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Stomatitis, Xerostomia, Oral Ulcer, Mucositis

NCT01843673 2016-07-06

Image-Guided Adaptive Radiotherapy for in Detecting Tumors During Treatment in Patients With Head and Neck Cancer

16 enrolled 9 charts

Lymphoid Interstitial Pneumonia, Head and Neck Neoplasms, Laryngeal Diseases

NCT01287390 2016-01-27

Adaptive, Image-guided, Intensity-modulated Radiotherapy for Head and Neck Cancer in the Reduced Volumes of Elective Neck

100 enrolled

Carcinoma, Squamous Cell, Laryngeal Diseases

NCT00589667 2014-04-02

A Phase II Study of Pemetrexed Plus Gemcitabine for Metastatic/Recurrent Head and Neck Cancer (HNSCC)

26 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Head and Neck Neoplasms, Laryngeal Diseases

NCT01208883 2014-01-24

A Feasibility Study On Continuous Adaptive [18f]Fdg-Pet-Guided Radiotherapy For Head and Neck Cancer

10 enrolled

Carcinoma, Squamous Cell, Laryngeal Diseases

NCT01057589 2013-09-18

A Study for Patients With Recurrent or Metastatic Squamous Cell Head and Neck Cancer

66 enrolled 11 charts

Head and Neck Neoplasms, Laryngeal Diseases, Thyroid Diseases

NCT01427205 2013-04-05

Phase II Study of Cetuximab With or Without OSI-906 in Head and Neck Squamous Cell Carcinoma (HNSCC)

Phase 2 Withdrawn

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Diseases, Neoplasm Metastasis, Recurrence

NCT00128817 2013-01-23

Concurrent Chemoradiation Versus Surgery With Adjuvant Therapy in Advanced Laryngopharyngeal Cancers

Phase 3 Terminated

900 enrolled

Laryngeal Diseases, Laryngeal Neoplasms, Neoplasms

NCT00100789 2012-10-01

S0329, Gemcitabine and Paclitaxel in Treating Patients With Persistent, Recurrent, or Metastatic Head and Neck Cancer

67 enrolled 10 charts