Clinical Trials

Diffuse Intrinsic Pontine Glioma, Ependymoma, Medulloblastoma, Recurrence

NCT04661384 2026-03-05

Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

10 enrolled

Ependymoma, Glioblastoma, Medulloblastoma, Meningeal Carcinomatosis

NCT02574728 2026-03-02

AflacST1502

46 enrolled

CNSMyeloidSarcoma

Brain Neoplasms, Carcinoma, Ependymoma, Histiocytosis, Langerhans-Cell, Medulloblastoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Neuroblastoma, Pinealoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT04696029 2026-03-02

DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

118 enrolled

Medulloblastoma

NCT01356290 2026-02-23

MEMMAT

232 enrolled

Ependymoma, Medulloblastoma, Recurrence

NCT03581240 2026-02-20

An Intermediate Expanded Use Trial of DFMO

Available

Typical Teratoid Rhabdoid Tumor, Medulloblastoma, Neuroblastoma, Neuroectodermal Tumors, Primitive

NCT03911388 2026-02-17

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Phase 4 Active not recruiting

24 enrolled

CNSSarcoma

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT02875314 2026-02-12

HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors

250 enrolled

Medulloblastoma

NCT05535166 2026-02-12

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

130 enrolled

Brain Neoplasms, Medulloblastoma

NCT03361033 2026-02-05

Components of Social Functioning in Survivors of Pediatric Brain Tumors

Completed

80 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Medulloblastoma, Social Adjustment

NCT07390539 2026-02-05

B7-H3.CD28Z.CART in CNS Neoplasms

70 enrolled

Brain Neoplasms, Ependymoma, Medulloblastoma, Meningeal Neoplasms, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT07087002 2026-01-27

GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults

18 enrolled

Brain Neoplasms, Medulloblastoma, Pinealoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT05230758 2026-01-22

Met Med Can

Phase 3 Recruiting

140 enrolled

Medulloblastoma, Cognitive Dysfunction

NCT00840047 2026-01-20

Methionine PET/CT Studies In Patients With Cancer

503 enrolled

CNSLymphoidSarcoma

Craniopharyngioma, Ependymoma, Hodgkin Disease, Lymphoma, Non-Hodgkin, Medulloblastoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT05835687 2026-01-20

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

48 enrolled

Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Central Nervous System Neoplasms, Rhabdoid Tumor

NCT07085325 2026-01-20

CSIMEMPHIS: Long-term Follow-up of Medulloblastoma Survivors That Received Craniospinal Irradiation

184 enrolled

Phase 1/2 Not yet recruiting

Medulloblastoma

NCT07346157 2026-01-16

PNOC044

69 enrolled

Medulloblastoma

NCT05106296 2026-01-09

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

37 enrolled

Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT04049669 2026-01-08

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

130 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Medulloblastoma

NCT06466798 2026-01-08

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

Phase 1 Withdrawn

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms

NCT06514898 2025-12-18

MATCHPOINT

12 enrolled

Medulloblastoma

NCT03500991 2025-12-17

HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

10 enrolled

Choroid Plexus Carcinoma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT03638167 2025-12-17

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

Phase 1 Completed

11 enrolled

Choroid Plexus Carcinoma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT04185038 2025-12-15

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

90 enrolled

Choroid Plexus Carcinoma, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT05128903 2025-12-15

Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study

22 enrolled

Phase 2/3 Active not recruiting

Brain Neoplasms, Medulloblastoma

NCT02066220 2025-12-04

International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma

360 enrolled

Brain Neoplasms, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT02238899 2025-12-04

Multicenter Register for Children and Young Adults With Intracranial Localized Medulloblastoma, CNS-PNET or Ependymoma

Completed

354 enrolled

Ependymoma, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT02417324 2025-12-04

International HIT-MED Registry (I-HIT-MED)

500 enrolled

Ependymoma, Medulloblastoma, Pinealoma

NCT04081701 2025-11-21

DOMINO-START

Phase 4 Recruiting

200 enrolled

CNSEndocrine

Medulloblastoma, Meningioma, Paraganglioma, Pituitary Neoplasms, Central Nervous System Neoplasms, Esthesioneuroblastoma, Olfactory, Hemangioblastoma

NCT07242963 2025-11-21

Relapsed and Progressive Sonic Hedgehog Medulloblastoma With U1 Mutation Registry Study

300 enrolled

Medulloblastoma, Recurrence

NCT01878617 2025-11-13

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

660 enrolled

CNSGastrointestinalGenitourinarySarcoma

Brain Neoplasms, Medulloblastoma, Infratentorial Neoplasms, Neuroectodermal Tumors, Primitive

NCT02162732 2025-11-03

Molecular-Guided Therapy for Childhood Cancer

Phase NA Completed

186 enrolled 12 charts

Carcinoma, Renal Cell, Craniopharyngioma, Ependymoma, Glioma, Carcinoma, Hepatocellular, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Choroid Plexus Neoplasms, Sarcoma, Clear Cell, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT00897286 2025-10-20

Study of Stored Tumor Samples in Young Patients With Brain Tumors

Terminated

139 enrolled

Familial ependymoma, Glioma, Medulloblastoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT05278208 2025-10-20

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

Phase 1/2 Recruiting

65 enrolled

Phase 2 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Central Nervous System Neoplasms

NCT06804655 2025-10-02

EViDENCE-BT

40 enrolled

Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Neurologic Manifestations

NCT01351870 2025-09-15

SIOP-PNET-4

Phase 3 Completed

52 enrolled

Medulloblastoma

NCT05096481 2025-09-09

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

120 enrolled

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Diffuse Intrinsic Pontine Glioma, Glioma, Medulloblastoma

NCT05064306 2025-08-01

131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young Adults

No longer available

Medulloblastoma, Meningeal Neoplasms, Wilms Tumor, Neuroblastoma, Pinealoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT06624371 2025-07-22

AflacBT2303

18 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma, Medulloblastoma

NCT02040376 2025-07-16

Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma

Phase 3 Completed

24 enrolled

Phase EARLY_PHASE1 Active not recruiting

Medulloblastoma

NCT03893487 2025-07-11

PNOC016

30 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma, Medulloblastoma

NCT03299309 2025-07-09

PRiME

30 enrolled

CNSDermatologicEndocrineNETThoracic

Brain Neoplasms, Glioma, Medulloblastoma

NCT03583528 2025-06-13

DOTATOC PET/CT for Imaging NET Patients

Active not recruiting

800 enrolled

Carcinoid Tumor, Vipoma, Ganglioneuroma, Glucagonoma, Insulinoma, Medulloblastoma, Meningioma, Neuroblastoma, Paraganglioma, Pheochromocytoma, Pituitary Neoplasms, Carcinoma, Merkel Cell, Gastrinoma, Carcinoma, Medullary, Neuroendocrine Tumors, Small Cell Lung Carcinoma

NCT04743310 2025-06-13

Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System

Phase 2 Completed

50 enrolled

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Neuroma, Acoustic, Pinealoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT06779487 2025-04-11

BIO-RIN

200 enrolled

Phase EARLY_PHASE1 Completed

Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma

NCT02905110 2025-03-25

Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children with Recurrent Posterior Fossa Brain Tumors

3 enrolled

Brain Neoplasms, Ependymoma, Medulloblastoma, Rhabdoid Tumor

NCT06323408 2025-03-25

BZKF-AYA

Not yet recruiting

72 enrolled

Phase EARLY_PHASE1 Completed

Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal

NCT00638898 2025-03-20

Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor

Phase 1 Completed

25 enrolled

CNSGenitourinarySarcoma

Familial ependymoma, Astrocytoma, Brain Neoplasms, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Testicular Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Optic Nerve Glioma

NCT04315064 2025-03-10

Infusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults with Recurrent Medulloblastoma

2 enrolled