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Phase 1 × Melanoma × pevonedistat × Clear all

Phase

Status

Sponsor Class

Study Type

Interventional 1

Sponsor

Cancer Type

Conditions

Leukemia, Myeloid, Acute 8 Myelodysplastic Syndromes 5 Precursor Cell Lymphoblastic Leukemia-Lymphoma 2 Neoplasms 2 Multiple Myeloma 2 Lymphoma 2 Advanced Solid Neoplasm 2 Solid Tumors 1 Renal Insufficiency 1 Melanoma 1 Lymphoma, Non-Hodgkin 1 Lymphoma, Mantle-Cell 1 Lymphoma, Large B-Cell, Diffuse 1 Lymphoma, Follicular 1 Lymphoma, B-Cell, Marginal Zone 1 Liver Diseases 1 Leukemia, Prolymphocytic, B-Cell 1 Leukemia, Myelomonocytic, Chronic 1 Leukemia, Lymphocytic, Chronic, B-Cell 1 Hodgkin Disease 1 Hematologic Neoplasms 1 Central Nervous System Neoplasms 1 Advanced Solid Tumors 1 Advanced Nonhematologic Malignancies 1

Interventions

pembrolizumab 82 Nivolumab 50 Ipilimumab 50 Cyclophosphamide 50 fludarabine 25 Vemurafenib 24 aldesleukin 23 Interleukin-2 23 trametinib 19 fludarabine phosphate 19 dabrafenib 15 Biopsy 14 Temozolomide 13 Cisplatin 12 atezolizumab 11 spartalizumab 10 Introns 10 poly ICLC 9 cobimetinib 9 Specimen Handling 9 Radiosurgery 9 MART-1 Antigen 9 Carboplatin 9 incomplete Freund's adjuvant 8 Radiotherapy 8 Radiation 8 Paclitaxel 8 Magnetic Resonance Spectroscopy 8 Filgrastim 8 Docetaxel 8

Date Range

30 days 90 days 1 year All

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Has results Has announcements

NCT01011530 2013-07-16

Dose Escalation Study of MLN4924 in Adults With Melanoma

Millennium Pharmaceuticals, Inc.

Phase 1 Completed

Melanoma

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