Clinical Trials

9 enrolled

Phase 1 Active not recruiting

Meningeal Carcinomatosis

NCT04192981 2025-04-17

GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases

21 enrolled

Phase 1 Active not recruiting

Brain Neoplasms, Meningeal Carcinomatosis

NCT05034497 2025-03-26

ReSPECT-LM

18 enrolled

Meningeal Carcinomatosis

NCT06431685 2024-05-28

Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer

Phase 1 Recruiting

10 enrolled

Meningeal Carcinomatosis

NCT06137651 2024-04-01

Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Phase 1 Withdrawn

BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT03520504 2022-12-23

Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases

Meningeal Carcinomatosis

NCT03661424 2022-12-20

BATs in Patients With Breast Cancer and Leptomeningeal Metastases

3 enrolled

BreastCNS

Breast Neoplasms, Meningeal Carcinomatosis

NCT02423525 2022-03-10

Safety Study of Afatinib for Brain Cancer

Astrocytoma, Brain Neoplasms, Glioblastoma, Meningioma, Oligodendroglioma, Meningeal Carcinomatosis

NCT02228369 2021-01-05

BLOOM

108 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT00512460 2016-05-16

RTA 744 Injection in Patients With Leptomeningeal Disease

CNSLymphoidOther hematologic neoplasm

7 enrolled

Brain Neoplasms, Leukemia, Lymphoma, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00031928 2015-04-30

Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors

3,000 enrolled

Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00854867 2014-02-24

Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis.

18 enrolled

Brain Neoplasms, Meningeal Carcinomatosis

NCT00002750 2013-02-20

Melphalan in Patients With Neoplastic Meningitis

CNSGynecologicLymphoidOther hematologic neoplasmSarcoma

6 enrolled

Burkitt Lymphoma, Hodgkin Disease, Leukemia, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Ovarian Neoplasms, Recurrence, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Central Nervous System Neoplasms, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Dendritic Cell Sarcoma, Interdigitating, Meningeal Carcinomatosis

NCT00003020 2013-02-20

LMB-7 Immunotoxin in Treating Patients With Leptomeningeal Metastases

Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00003462 2013-02-20

Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors

20 enrolled

Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00005842 2013-02-11

Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer

BreastCNSEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Thyroid Cancer, Papillary, Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Vipoma, Esophageal Neoplasms, Gallbladder Neoplasms, Glucagonoma, Carcinoma, Hepatocellular, Insulinoma, Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Parathyroid Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Somatostatinoma, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Gastrinoma, Pleural Effusion, Malignant, Endometrial Neoplasms, Adenocarcinoma, Follicular, Adrenocortical Carcinoma, Carcinoma, Islet Cell, Carcinoma, Medullary, Breast Neoplasms, Male, Meningeal Carcinomatosis, Inflammatory Breast Neoplasms, Thyroid Carcinoma, Anaplastic

NCT00074607 2012-11-12

Intrathecal Gemcitabine to Treat Neoplastic Meningitis, IT Gemcitabine

10 enrolled

Meningitis, Neoplasms, Meningeal Carcinomatosis

NCT00025311 2012-11-09

Topotecan in Treating Patients With Recurrent, Progressive, or Refractory Cancer That is Metastatic to the Lining Around the Brain

Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00477503 2012-08-01

Nuclear Imaging of Human CSF Flow Using Ga-67 Citrate and In-111 DTPA

1 enrolled

Brain Neoplasms, Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00515788 2012-03-12

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

11 enrolled

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00112619 2011-06-30

Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors

CNSLymphoidOther hematologic neoplasmSarcoma

19 enrolled

Familial ependymoma, Astrocytoma, Burkitt Lymphoma, Leukemia, Lymphoma, Medulloblastoma, Neoplasms, Unknown Primary, Oligodendroglioma, Recurrence, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor, Optic Nerve Glioma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Dendritic Cell Sarcoma, Interdigitating, Meningeal Carcinomatosis

NCT00003073 2010-03-23

Chemotherapy in Treating Young Patients With Recurrent or Refractory Meningeal Leukemia, Lymphoma, or Solid Tumors

Phase 1 Unknown

15 enrolled

CNSLymphoidOther hematologic neoplasmSarcoma

Burkitt Lymphoma, Leukemia, Lymphoma, Recurrence, Lymphoma, Large B-Cell, Diffuse, Central Nervous System Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Dendritic Cell Sarcoma, Interdigitating, Meningeal Carcinomatosis

NCT00006246 2009-10-07

Busulfan in Treating Children and Adolescents With Refractory CNS Cancer