Clinical Trials Browser

Phase 1 × OTHER × Meningeal Carcinomatosis × Clear all

NCT04661384 2026-03-05

Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

Phase 1 Active not recruiting

Ependymoma, Glioblastoma, Medulloblastoma, Meningeal Carcinomatosis

NCT03719768 2026-03-02

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

Phase 1 Completed

Brain Neoplasms, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT06663306 2026-03-02

Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC

Phase 1 Recruiting

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT05184816 2026-01-30

A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis

Phase 1 Recruiting

Recurrence, Meningeal Carcinomatosis

NCT06724926 2026-01-02

Concurrent Azeliragon With Craniospinal Irradiation

Phase 1 Recruiting

Glioma, Meningeal Carcinomatosis

NCT07199413 2025-09-30

Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and Immunotherapy: A Phase I Pilot Safety and Feasibility Study for Solid Tumor Patients With CNS Metastases

Phase 1 Not yet recruiting

Brain Neoplasms, Meningeal Carcinomatosis

NCT04192981 2025-04-17

GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases

Phase 1 Active not recruiting

Brain Neoplasms, Meningeal Carcinomatosis

NCT03696030 2025-04-13

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

Phase 1 Active not recruiting

Brain Neoplasms, Breast Neoplasms, Neoplasms, Meningeal Carcinomatosis

NCT06431685 2024-05-28

Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer

Phase 1 Recruiting

Meningeal Carcinomatosis

NCT06137651 2024-04-01

Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Phase 1 Withdrawn

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT03520504 2022-12-23

Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases

Phase 1 Completed

Meningeal Carcinomatosis

NCT03661424 2022-12-20

BATs in Patients With Breast Cancer and Leptomeningeal Metastases

Phase 1 Terminated

Breast Neoplasms, Meningeal Carcinomatosis

NCT02423525 2022-03-10

Safety Study of Afatinib for Brain Cancer

Phase 1 Completed

Astrocytoma, Brain Neoplasms, Glioblastoma, Meningioma, Oligodendroglioma, Meningeal Carcinomatosis

NCT03101579 2019-03-19

Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer

Phase 1 Completed

Recurrence, Meningeal Carcinomatosis

NCT00512460 2016-05-16

RTA 744 Injection in Patients With Leptomeningeal Disease

Phase 1 Terminated

CNSLymphoidOther hematologic neoplasm

Brain Neoplasms, Leukemia, Lymphoma, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00416923 2015-02-16

Intrathecal Rituximab in Treating Patients With Recurrent CNS Lymphoma

Phase 1 Completed

CNSLymphoidOther hematologic neoplasm

Burkitt Lymphoma, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Central Nervous System Neoplasms, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Meningeal Carcinomatosis, Intraocular Lymphoma

NCT00002750 2013-02-20

Melphalan in Patients With Neoplastic Meningitis

Phase 1 Completed

CNSGynecologicLymphoidOther hematologic neoplasmSarcoma

Burkitt Lymphoma, Hodgkin Disease, Leukemia, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Ovarian Neoplasms, Recurrence, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Central Nervous System Neoplasms, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Dendritic Cell Sarcoma, Interdigitating, Meningeal Carcinomatosis

NCT00003020 2013-02-20

LMB-7 Immunotoxin in Treating Patients With Leptomeningeal Metastases

Phase 1 Completed

Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00003462 2013-02-20

Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors

Phase 1 Completed

Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00074607 2012-11-12

Intrathecal Gemcitabine to Treat Neoplastic Meningitis, IT Gemcitabine

Phase 1 Terminated

Meningitis, Neoplasms, Meningeal Carcinomatosis

NCT00025311 2012-11-09

Topotecan in Treating Patients With Recurrent, Progressive, or Refractory Cancer That is Metastatic to the Lining Around the Brain

Phase 1 Completed

Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00477503 2012-08-01

Nuclear Imaging of Human CSF Flow Using Ga-67 Citrate and In-111 DTPA

Phase 1 Terminated

Brain Neoplasms, Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00515788 2012-03-12

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

Phase 1 Terminated

Meningeal Neoplasms, Meningeal Carcinomatosis