Clinical Trials Browser

Breast Neoplasms, Meningeal Carcinomatosis

NCT06592092 2026-01-29

Clinical Study of QH104 Cell Injection for the Treatment of Meningeal Metastases of B7H3+ Solid Tumors

Phase NA Completed

3 enrolled

CNS

Meningeal Carcinomatosis

NCT07348965 2026-01-16

Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis

Phase NA Not yet recruiting

42 enrolled

CNSThoracic

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT05746325 2025-10-27

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Phase NA Recruiting

5 enrolled

BreastCNSThoracic

Breast Neoplasms, Lung Neoplasms, Meningeal Carcinomatosis

NCT06304441 2025-09-29

Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer

Phase NA Recruiting

100 enrolled

CNS

Meningeal Carcinomatosis

NCT03974204 2025-09-26

Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis.

Phase NA Withdrawn

BreastCNS

Breast Neoplasms, Meningeal Carcinomatosis

NCT06984523 2025-05-25

Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal Metastasis

Phase NA Not yet recruiting

20 enrolled

CNS

Meningeal Carcinomatosis

NCT05746754 2025-04-06

CSI ProLong

Phase NA Recruiting

50 enrolled

CNS

Meningeal Carcinomatosis

NCT06766591 2025-01-09

Ivonescimab Combined With Chemotherapy for the Treatment of Leptomeningeal Metastases Failed to EGFR-TKIs

Phase NA Not yet recruiting

36 enrolled

CNS

Meningeal Carcinomatosis

NCT05305885 2022-09-30

Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis

Phase NA Unknown

100 enrolled

CNS

Meningeal Carcinomatosis

NCT04944069 2021-06-29

ATTRACT

Phase NA Unknown

69 enrolled

CNSThoracic

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT01713699 2021-01-22

Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases

Phase NA Completed

146 enrolled

CNS

Neoplastic Cells, Circulating, Meningeal Carcinomatosis

NCT00964743 2013-09-09

Depocyt® With Sorafenib in Neoplastic Meningitis

Phase NA Terminated

2 enrolled 6 charts

BreastCNS

Breast Neoplasms, Neurologic Manifestations, Meningeal Carcinomatosis

NCT01438021 2012-11-09

Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease

Phase NA Withdrawn

CNS

Meningeal Carcinomatosis

Clinical Trials

Exo-LCR

Clinical Study of QH104 Cell Injection for the Treatment of Meningeal Metastases of B7H3+ Solid Tumors

Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer

Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis.

Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal Metastasis

CSI ProLong

Ivonescimab Combined With Chemotherapy for the Treatment of Leptomeningeal Metastases Failed to EGFR-TKIs

Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis

ATTRACT

Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases

Depocyt® With Sorafenib in Neoplastic Meningitis

Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease