Clinical Trials Browser

Breast Neoplasms, Meningeal Carcinomatosis

Ependymoma, Glioblastoma, Medulloblastoma, Meningeal Carcinomatosis

Brain Neoplasms, Meningeal Neoplasms, Meningeal Carcinomatosis

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

Brain Neoplasms, Glioblastoma, Neoplasm Metastasis, Meningeal Carcinomatosis

Meningeal Neoplasms, Meningeal Carcinomatosis

Recurrence, Meningeal Carcinomatosis

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

Meningeal Carcinomatosis

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

Glioma, Meningeal Carcinomatosis

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

Meningeal Carcinomatosis

Breast Neoplasms, Meningeal Carcinomatosis

Meningeal Neoplasms, Meningeal Carcinomatosis

Meningeal Carcinomatosis

Breast Neoplasms, Lung Neoplasms, Meningeal Carcinomatosis

Brain Neoplasms, Meningeal Carcinomatosis

Meningeal Carcinomatosis

Breast Neoplasms, Meningeal Carcinomatosis

Meningeal Carcinomatosis

Breast Neoplasms, Meningeal Carcinomatosis

Glioblastoma, Meningeal Carcinomatosis

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

Meningeal Carcinomatosis

Meningeal Carcinomatosis

Brain Neoplasms, Breast Neoplasms, Neoplasm Metastasis, Meningeal Carcinomatosis

Meningeal Carcinomatosis

Meningeal Carcinomatosis

Meningeal Carcinomatosis

Meningeal Carcinomatosis

Meningeal Carcinomatosis

Brain Neoplasms, Meningeal Carcinomatosis

Brain Neoplasms, Breast Neoplasms, Neoplasms, Meningeal Carcinomatosis

Meningeal Carcinomatosis

Meningeal Carcinomatosis

Meningeal Carcinomatosis

Meningeal Carcinomatosis

Brain Neoplasms, Meningeal Carcinomatosis

Meningeal Carcinomatosis

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

Lymphoma, B-Cell, Meningeal Carcinomatosis

Breast Neoplasms, Meningeal Carcinomatosis

Meningeal Carcinomatosis

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

Clinical Trials

Exo-LCR

Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis

Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib.

Clinical Study of QH104 Cell Injection for the Treatment of Meningeal Metastases of B7H3+ Solid Tumors

Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

Concurrent Azeliragon With Craniospinal Irradiation

Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal Metastasis

HIT

ETIC-LM

Ipilimumab and Nivolumab in Leptomeningeal Metastases

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and Immunotherapy: A Phase I Pilot Safety and Feasibility Study for Solid Tumor Patients With CNS Metastases

Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer

Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer

Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors

Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis.

Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced Spread

A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases

Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases

Pembrolizumab And Lenvatinib In Leptomeningeal Metastases

DEBBRAH

Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal Metastasis

Intrathecal Combination of Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis

Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis

Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal Metastasis

Intrathecal Pemetrexed for Leptomeningeal Metastasis

GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

CSI ProLong

A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases

Cerebrospinal Fluid Cytology-guided Intrathecal Chemo-holiday Therapy for EGFR-positive NSCLC Leptomeningeal Metastases

High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis

ORBITAL

Ivonescimab Combined With Chemotherapy for the Treatment of Leptomeningeal Metastases Failed to EGFR-TKIs

Better Brain

SCNSL1

Microfluidic Device to Diagnose Leptomeningeal Metastasis in Breast Cancer

Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer

Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases

Aumolertinib Combined Intrathecal Chemotherapy for Leptomeningeal Metastasis From EGFR-Mutated NSCLC and Prognostic Value of Dynamic Changes in cfDNA Profiles