NCT02422641 2026-03-18
Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis
Wake Forest University Health Sciences
Phase 2 Recruiting
Clinical Trials
21 trialsNCT07476781 2026-03-17
CSF and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and CNS Metastases or no CNS Metastases
Sunnybrook Health Sciences Centre
Phase NA Recruiting
NCT05865990 2026-03-12
TUXEDO-3
MedSIR
Phase 2 Active not recruiting
NCT03719768 2026-03-02
Avelumab With Radiotherapy in Patients With Leptomeningeal Disease
H. Lee Moffitt Cancer Center and Research Institute
Phase 1 Completed
NCT00338377 2026-02-23
Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma
M.D. Anderson Cancer Center
Phase 2 Active not recruiting
NCT06016387 2026-02-23
Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study
Sunnybrook Health Sciences Centre
Phase 2 Recruiting
NCT07415018 2026-02-17
Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal Disease
M.D. Anderson Cancer Center
Phase NA Not yet recruiting
NCT04588545 2026-02-09
Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease
H. Lee Moffitt Cancer Center and Research Institute
Phase 1/2 Recruiting
NCT07390539 2026-02-05
B7-H3.CD28Z.CART in CNS Neoplasms
Dana-Farber Cancer Institute
Phase 1 Not yet recruiting
NCT03025256 2026-01-08
Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease
M.D. Anderson Cancer Center
Phase 1 Active not recruiting
NCT05809752 2026-01-08
A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)
H. Lee Moffitt Cancer Center and Research Institute
Phase 1 Recruiting
NCT05305365 2025-12-23
Study Assessing QBS72S For Treating Brain Metastases
Stanford University
Phase 2 Active not recruiting
NCT05800275 2025-11-18
ETIC-LM
UNICANCER
Phase 2 Recruiting
NCT03501979 2025-08-29
Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD
University of Alabama at Birmingham
Phase 2 Terminated
NCT06933199 2025-05-04
NeoSTROBE
University Hospital Ostrava
Phase NA Recruiting
NCT05112549 2025-04-03
IT-PD1
University Hospital Tuebingen
Phase 1 Recruiting
NCT03711422 2022-06-14
Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC
National Cancer Centre, Singapore
Phase 1 Terminated
NCT00062881 2020-03-04
Intrathecal Mafosfamide
Baylor College of Medicine
Phase 1 Completed
NCT01596127 2018-05-24
Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System
M.D. Anderson Cancer Center
Phase 1/2 Terminated
NCT00512460 2016-05-16
RTA 744 Injection in Patients With Leptomeningeal Disease
M.D. Anderson Cancer Center
Phase 1 Terminated
NCT00515788 2012-03-12
DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis
M.D. Anderson Cancer Center
Phase 1 Terminated