Clinical Trials

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms

NCT05136196 2026-03-17

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

150 enrolled

DermatologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Melanoma, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07209189 2026-03-09

(NeoScorch HN)

75 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT06627270 2026-03-05

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Mouth Neoplasms

NCT06868433 2026-03-04

TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer

Phase 1 Recruiting

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Recurrence

NCT06798922 2026-03-03

OPTIFLAP

Phase 3 Recruiting

348 enrolled

Mouth Neoplasms

NCT07343596 2026-03-03

Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery

20 enrolled

Mouth Neoplasms

NCT02734537 2026-03-02

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

189 enrolled

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms

NCT06336941 2026-02-25

HOUSTON

400 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT07063212 2026-02-19

A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)

Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05075980 2026-02-13

Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study

174 enrolled

Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Lymphatic Metastasis, Mouth Neoplasms, Oropharyngeal Neoplasms, Paranasal Sinus Neoplasms, Salivary Gland Neoplasms

NCT07110142 2026-02-13

T-PROSE

Head and Neck Neoplasms, Mouth Neoplasms

NCT01269190 2026-02-11

Wide-Field and High Resolution In Vivo Imaging in Visualizing Lesions in Patients With Oral Neoplasia Undergoing Surgery

275 enrolled

Mouth Neoplasms

NCT06636734 2026-02-11

Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial

28 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07401641 2026-02-10

Effect of Dezocine Versus Nalbuphine Combined With Sufentanil on Postoperative Analgesia, Complications, and Free Flap Survival in Patients Undergoing Oral Cancer Radical Surgery: A Randomized Controlled Clinical Trial.

60 enrolled

Mouth Neoplasms

NCT06532279 2026-02-02

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

98 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Stomatitis

NCT06736379 2026-01-20

Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

Phase 1 Recruiting

41 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms

NCT04333537 2026-01-14

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Phase 2/3 Recruiting

686 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT07237672 2025-12-16

AI Based Physiotherapy 3- and 9-Month Follow-Up in Oral Cancer Patients

65 enrolled

Mouth Neoplasms

NCT06682494 2025-12-12

Enhancing Oral Cancer Awareness

60 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05793151 2025-12-11

ENDURE

532 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07095608 2025-11-21

Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain

80 enrolled

Carcinoma, Squamous Cell, Mouth Neoplasms

NCT06295731 2025-11-17

HexAgon-HN

Phase 2/3 Recruiting

410 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT04265430 2025-11-14

Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors

Phase 4 Recruiting

425 enrolled

Mouth Neoplasms, Osteoradionecrosis

NCT04870762 2025-10-08

Customized 3D Printed Oral Stents During Head and Neck Radiotherapy

119 enrolled

Maxillary Sinus Neoplasms, Mouth Neoplasms, Parotid Neoplasms, Tongue Neoplasms, Tonsillar Neoplasms

NCT06915454 2025-10-03

High-Resolution PET-CT Imaging for Surgical Margin Visualization

50 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Mouth Neoplasms, Neoplasms, Tongue Neoplasms

NCT07203911 2025-10-02

SURGIO

200 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Tongue Neoplasms

NCT07180901 2025-09-18

PRONTO-HN

85 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT06785051 2025-09-16

AI-based Physiotherapy for Oral Cancer Patients

100 enrolled

Mouth Neoplasms

NCT05757817 2025-09-15

LAMBEAU STEPA

Head and Neck Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05973656 2025-08-22

Role of Acetaldehyde in the Development of Oral Cancer

Classical hematologyHead & Neck

170 enrolled

Fanconi Anemia, Mouth Neoplasms

NCT07121595 2025-08-13

Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial

50 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT05429099 2025-07-24

ViPMR

Phase 2/3 Recruiting

420 enrolled

Mouth Neoplasms

NCT06997068 2025-07-14

Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Oral Cavity Cancer in a Rural Midwest United States Population

25 enrolled

Mouth Neoplasms

NCT05740033 2025-06-12

Radial Forearm Donor Site Closure

120 enrolled

Mouth Neoplasms

NCT02584270 2025-05-16

PGSRT

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Mouth Neoplasms, Tongue Neoplasms

NCT06673329 2025-05-14

Brodalumab in the Treatment of Immune-Related Adverse Events

Phase 1 Recruiting

11 enrolled

Brain Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms

NCT04809324 2025-04-11

Gross Examinations Versus Frozen Section for Assessment of Surgical Margins in Oral Cancers

1,206 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT06662058 2025-04-10

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

118 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05784012 2025-03-13

RADIAN

Phase 1/2 Recruiting

34 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT06737822 2025-03-04

SurVIC

Phase 3 Recruiting

346 enrolled

Head and Neck Neoplasms, Mouth Neoplasms

NCT04191460 2025-02-26

GuidedbyLight

28 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Neoplasms

NCT05966194 2024-11-15

KEVLARx

216 enrolled

Head & NeckOther

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Stomatitis, Mucositis

NCT06623266 2024-11-14

Neck Observation or Elective Neck Dissection in CT1N0M0 OSCC

300 enrolled

Squamous Cell Carcinoma of Head and Neck, Lymphatic Metastasis, Mouth Neoplasms

NCT06666634 2024-10-30

NANOSCAN

DermatologicGenitourinaryHead & Neck

29 enrolled

Melanoma, Mouth Neoplasms, Penile Neoplasms

NCT06425146 2024-08-22

TACO

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT05719779 2024-08-15

Ronco-Onco

35 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms, Pharyngeal Neoplasms, Sleep Apnea Syndromes, Snoring

NCT04787939 2024-04-12

Early Feeding After Oral Cavity Reconstruction

89 enrolled

Head and Neck Neoplasms, Mouth Neoplasms

NCT06219980 2024-03-12

SBRT Followed by Neoadjuvant Chemoimmunotherapy of Sindilizumab Plus Docetaxel and Cisplatin for Locoregionally Advanced Squamous Carcinoma of Oral Cavity and Oropharynx

25 enrolled