NCT05104866 2026-02-04A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)AstraZenecaPhase 3 Active not recruiting732 enrolled 22 charts 1 FDA
NCT05374512 2026-01-27A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)AstraZenecaPhase 3 Active not recruiting644 enrolled
NCT03734029 2025-10-06Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]Daiichi SankyoPhase 3 Active not recruiting557 enrolled 22 charts 1 FDA
NCT02734290 2025-03-10Standard of Care Chemotherapy Plus Pembrolizumab for Breast CancerProvidence Health & ServicesPhase 1/2 Active not recruiting29 enrolled 12 charts