Clinical Trials

GastrointestinalHead & NeckThoracic

21 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis, Stomach Neoplasms

NCT06560645 2026-02-02

A Study of PRT7732, an Oral SMARCA2 Degrader, in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation

42 enrolled

GastrointestinalThoracic

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT03436056 2026-01-29

PRIMING

2 enrolled 10 charts

Thoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00923806 2026-01-23

Gene Therapy Using Anti-CEA Cells to Treat Metastatic Cancer

3 enrolled

Neoplasm Metastasis

NCT02408861 2026-01-21

Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lymphoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

GastrointestinalSarcomaThoracic

79 enrolled 24 charts

Anus Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Sarcoma, Kaposi, HIV Infections

NCT06337630 2026-01-02

POP-ART

10 enrolled

Neoplasm Metastasis

NCT04294160 2025-12-24

A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer

122 enrolled

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT05035407 2025-12-02

T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers

36 enrolled 7 charts

Carcinoma, Neoplasm Metastasis, Triple Negative Breast Neoplasms

NCT04272034 2025-10-16

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

105 enrolled

Nasopharyngeal Carcinoma, Esophageal Squamous Cell Carcinoma, Anus Neoplasms, Carcinoma, Basal Cell, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Mesothelioma, Neoplasm Metastasis, Carcinoma, Merkel Cell, Endometrial Neoplasms, Small Cell Lung Carcinoma

NCT06264921 2025-09-25

A Study With NKT3447 for Adults With Advanced/Metastatic Solid Tumors

BreastGastrointestinalGynecologicThoracic

23 enrolled

Neoplasm Metastasis, Ovarian Neoplasms, Stomach Neoplasms, Uterine Diseases, Endometrial Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT03871348 2025-09-10

A First-in-Human Dose Escalation and Expansion Study to Evaluate Intratumoral Administration of SAR441000 as Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors

77 enrolled

Neoplasm Metastasis

NCT05490043 2025-08-29

A Trial of ATG-101 in Patients With Metastatic/Advanced Solid Tumors and Mature B-cell Non-Hodgkin Lymphomas

33 enrolled

Neoplasm Metastasis

NCT04458259 2025-08-28

Study of PF-07265807 in Participants With Metastatic Solid Tumors.

DermatologicGastrointestinalGenitourinaryGynecologicThoracic

88 enrolled

Parkinson Disease 4, Autosomal Dominant Lewy Body, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Small Cell Lung Carcinoma

NCT06877533 2025-08-12

A First-in-Human Open-label, Phase I/Ib Dose Escalation and Expansion Cohort Study of EOS006215 as Monotherapy and in Combination With Pembrolizumab or Other Anticancer Treatments in Participants With Advanced Solid Tumors

3 enrolled

Neoplasm Metastasis, Neoplasms

NCT04042051 2025-07-22

Panthera

2 enrolled

Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT03991741 2025-07-03

Adoptive Cell Transfer of Autologous Tumor Infiltrating Lymphocytes and High-Dose Interleukin 2 in Select Solid Tumors

3 enrolled 9 charts

DermatologicHead & Neck

Head and Neck Neoplasms, Melanoma, Neoplasm Metastasis

NCT05274451 2025-07-01

A Study to Investigate LYL797 in Adults With Solid Tumors

BreastGynecologicThoracic

57 enrolled

Carcinoma, Ovarian Epithelial, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Fallopian Tube Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Recurrence, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT06630247 2025-06-25

A Dose-escalation, Dose-finding, and Expansion Study of XL495 in Participants With Locally Advanced or Metastatic Solid Tumors

9 enrolled

Genitourinary

Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Neoplasm Metastasis

NCT04986865 2025-06-09

PROBE

31 enrolled

Lymphoid

Lymphoma, Neoplasm Metastasis

NCT00253318 2025-04-27

RAD001 Plus Docetaxel in Patients With Metastatic Breast Cancer

15 enrolled

Breast Neoplasms, Neoplasm Metastasis

NCT05840510 2025-04-25

Adagrasib in Combination With Nab-Sirolimus in Patients With Advanced Solid Tumors and Non-Small Cell Lung Cancer With a KRAS G12C Mutation (KRYSTAL -19)

6 enrolled

Neoplasm Metastasis, Neoplasms

NCT05904236 2025-04-08

ICVB-1042

17 enrolled

Neoplasm Metastasis

NCT04553692 2025-03-28

Phase 1a/1b Study of Aplitabart (IGM-8444) Alone or in Combination in Participants with Relapsed, Refractory, or Newly Diagnosed Cancers

GastrointestinalLymphoidOther hematologic neoplasmSarcoma

272 enrolled

Chondrosarcoma, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Sarcoma, Colorectal Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute

NCT01529593 2025-03-24

Temsirolimus in Combination With Metformin in Patients With Advanced Cancers

34 enrolled

Neoplasm Metastasis

NCT04465487 2025-02-24

Study of REGN6569 and Cemiplimab in Adult Patients With Advanced Solid Tumor Malignancies

38 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis

NCT02751528 2025-01-13

QUILT-3.013: Study of Ad5 [E1-, E2b-]-HER2/Neu Vaccine (ETBX-021) in Subjects With Unresectable Locally Advanced or Metastatic HER2-Expressing Breast Cancer

3 enrolled 10 charts

Breast Neoplasms, Neoplasm Metastasis, Neoplasms, Breast Neoplasms, Male

NCT05781360 2024-12-20

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of SIM0237 in Adult Participants with Advanced Solid Tumors

192 enrolled

Neoplasm Metastasis

NCT04975256 2024-12-16

Adagrasib in Combination With BI 1701963 in Patients With Cancer (KRYSTAL 14)

7 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms

NCT05198349 2024-11-25

First in Human Study of M1069 in Advanced Solid Tumors

15 enrolled

Neoplasm Metastasis

NCT04135352 2024-11-12

V938-001

35 enrolled 21 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Neoplasm Metastasis

NCT06448364 2024-11-06

LTbR

DermatologicGastrointestinalGenitourinaryThoracic

4 enrolled

Non-Muscle Invasive Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasm Metastasis, Colorectal Neoplasms

NCT02097225 2024-10-16

Onalespib, Dabrafenib, and Trametinib in Treating Patients With BRAF-Mutant Melanoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

22 enrolled 21 charts

Dermatologic

Melanoma, Neoplasm Metastasis

NCT03604783 2024-09-19

Phase 1, First-in-human Study of Oral TP-1287 in Patients with Advanced Solid Tumors

74 enrolled

Sarcoma

Liposarcoma, Neoplasm Metastasis, Neoplasms, Sarcoma, Sarcoma, Ewing, Sarcoma, Synovial

NCT04594811 2024-08-16

NT-I7 in Combination With Nivolumab in Advanced Gastric, Gastro-Esophageal Junction or Esophageal Adenocarcinoma

10 enrolled

Neoplasm Metastasis

NCT04628780 2024-07-29

Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid Tumors

GastrointestinalGenitourinaryGynecologicHead & NeckThoracic

37 enrolled 32 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Neoplasm Metastasis, Ovarian Neoplasms, Colorectal Neoplasms

NCT03685591 2024-06-26

PF-06952229 Treatment in Adult Patients With Advanced Solid Tumors

BreastDermatologicGastrointestinalGenitourinaryOther solid neoplasmThoracic

49 enrolled 33 charts

Adenocarcinoma, Breast Neoplasms, Carcinoma, Renal Cell, Camurati-Engelmann Syndrome, Liver Neoplasms, Melanoma, Mesothelioma, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Neoplasms, Squamous Cell

NCT05631327 2024-05-28

A JZP341 Study in Adult Participants With Advanced or Metastatic Solid Tumors

12 enrolled

Neoplasm Metastasis

NCT04250597 2024-05-06

Study of GNX102 in Patients With Advanced Solid Tumors

46 enrolled

Neoplasm Metastasis

NCT04167137 2024-05-03

Safety and Tolerability of SYNB1891 Injection Alone or in Combination With Atezolizumab in Adult Participants

32 enrolled 19 charts

Lymphoid

Lymphoma, Neoplasm Metastasis

NCT03878524 2024-03-04

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

BreastClassical hematologyGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmPlasma cell

2 enrolled

Anemia, Blast Crisis, Breast Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Thrombocytosis, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis

NCT05408871 2024-02-15

Non-invasive Measurement of PD-L1 Levels With Positron Emission Tomography (PET) in Head and Neck Malignancies and Intracranial Metastases

7 enrolled

Head & NeckThoracic

Head and Neck Neoplasms, Lung Neoplasms, Neoplasm Metastasis

NCT03525392 2023-12-12

Study to Evaluate the Safety and Activity (Including Distribution) of 177Lu-3BP-227 in Subjects With Solid Tumours Expressing Neurotensin Receptor Type 1.

GastrointestinalHead & NeckSarcoma

14 enrolled 20 charts

Squamous Cell Carcinoma of Head and Neck, Bone Neoplasms, Neoplasm Metastasis, Recurrence, Stomach Neoplasms, Colorectal Neoplasms

NCT03861403 2023-11-30

A Dose Escalation and Expansion Study of TRX518 in Combination With Cyclophosphamide Plus Avelumab in Advanced Solid Tumors

BreastGenitourinaryGynecologic

10 enrolled

Breast Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Prostatic Neoplasms, Recurrence

NCT04729725 2023-08-14

SAR439459 and Cemiplimab for the Treatment of Advanced or Unresectable Solid Tumors, Strategic Alliance, TACTIC TRIAL

3 enrolled

Neoplasm Metastasis

NCT04849273 2023-05-26

A Study of TPX-0131, a Novel Oral ALK Tyrosine Kinase Inhibitor, in Patients With ALK+ Advanced or Metastatic NSCLC

11 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT02376699 2023-05-01

Safety Study of SEA-CD40 in Cancer Patients