Clinical Trials Browser

Phase 2 × Recruiting × Neoplasm Metastasis × Clear all

NCT03907475 2026-03-18

Durvalumab in Combination With Chemotherapy in Treating Patients With Advanced Solid Tumors, DURVA+ Trial

Phase 2 Recruiting

Neoplasm Metastasis

NCT05327010 2026-03-18

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

Phase 2 Recruiting

Neoplasm Metastasis

NCT05564377 2026-03-18

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Phase 2 Recruiting

Fallopian Tube Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Endometrial Neoplasms

NCT05638295 2026-03-17

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

Phase 2 Recruiting

Neoplasm Metastasis

NCT07477457 2026-03-17

A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma

Phase 2 Recruiting

Neoplasm Metastasis, Osteosarcoma

NCT04927416 2026-03-13

The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer

Phase 2 Recruiting

Neoplasm Metastasis, Thyroid Neoplasms

NCT05755113 2026-03-12

A Clinical Study to Investigate the Efficacy of Intratumoral Tigilanol Tiglate in Soft Tissue Sarcoma

Phase 2 Recruiting

Neoplasm Metastasis, Sarcoma

NCT06933329 2026-03-10

Zelenectide Pevedotin in NECTIN4 Amplified Advanced or Metastatic Non-small Cell Lung Cancer

Phase 2 Recruiting

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT06311214 2026-03-06

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

Phase 2 Recruiting

Neoplasm Metastasis

NCT07450859 2026-03-05

A Study of BT5528 in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)

Phase 2 Recruiting

Gastrointestinal

Neoplasm Metastasis, Pancreatic Neoplasms

NCT04771520 2026-03-02

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

Phase 2 Recruiting

DermatologicGastrointestinalSarcomaThoracic

Lung Neoplasms, Melanoma, Neoplasm Metastasis, Sarcoma, Colorectal Neoplasms

NCT07282834 2026-02-27

Charlie-2

Phase 2 Recruiting

Neoplasm Metastasis, Neoplasms, Peritoneal Neoplasms

NCT07432295 2026-02-25

Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

Phase 2 Recruiting

Gastrointestinal

Adenocarcinoma Of Esophagus, Neoplasm Metastasis, Stomach Neoplasms

NCT06630416 2026-02-24

Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors

Phase 2 Recruiting

Urinary Bladder Neoplasms, Neoplasm Metastasis

NCT06058988 2026-02-23

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Phase 2 Recruiting

Brain Neoplasms, Glioblastoma, Neoplasm Metastasis, Meningeal Carcinomatosis

NCT07193394 2026-02-23

H3RAKLES

Phase 2 Recruiting

Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT05853575 2026-02-17

Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)

Phase 2 Recruiting

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT06358677 2026-02-13

FACE

Phase 2 Recruiting

Neoplasm Metastasis

NCT05726383 2026-02-10

Iscador® P (Mistletoe) Immunotherapy for Recurrent Osteogenic Sarcoma

Phase 2 Recruiting

Bone Neoplasms, Neoplasm Metastasis, Sarcoma

NCT06778408 2026-02-05

HART

Phase 2 Recruiting

Neoplasm Metastasis

NCT07176312 2026-02-04

ZANGEA

Phase 2 Recruiting

Gastrointestinal

Neoplasm Metastasis, Stomach Neoplasms

NCT07183319 2026-02-02

Circulating Tumor DNA Response In Urothelial Cancer

Phase 2 Recruiting

Carcinoma, Transitional Cell, Neoplasm Metastasis

NCT05010031 2026-01-23

A Study of Reduced-dose Radiation in People With Metastatic Tumors With a Genetic Change

Phase 2 Recruiting

Neoplasm Metastasis, Hereditary Sensory and Autonomic Neuropathies

NCT05419518 2026-01-23

Palliative Dose Escalated Radiation for Painful Non-Spine Bone Metastases and Painful Non-Bone Metas

Phase 2 Recruiting

Bone Neoplasms, Neoplasm Metastasis

NCT05502315 2026-01-23

CANOPY

Phase 2 Recruiting

Neoplasm Metastasis

NCT05933395 2026-01-20

GERTRUDE

Phase 2 Recruiting

Neoplasm Metastasis

NCT06792695 2026-01-20

CANTOR

Phase 2 Recruiting

Gastrointestinal

Neoplasm Metastasis, Colorectal Neoplasms

NCT07042685 2026-01-16

Trial of 5-Fluorouracil (5FU)-Based Therapy in Combination With Fruquintinib in Patients With Locally Advanced Unresectable or Metastatic Colorectal Cancer

Phase 2 Recruiting

Gastrointestinal

Neoplasm Metastasis, Colorectal Neoplasms

NCT05716516 2026-01-14

ESTHER

Phase 2 Recruiting

Breast Neoplasms, Neoplasm Metastasis

NCT06790602 2026-01-13

SWITCH

Phase 2 Recruiting

Neoplasm Metastasis

NCT05472948 2025-12-17

Surufatinib and Sintilimab in Combination With Capecitabine for Metastatic Adenocarcinoma of Small Intestine or Appendix Carcinoma

Phase 2 Recruiting

Gastrointestinal

Appendiceal Neoplasms, Neoplasm Metastasis

NCT07274774 2025-12-10

SBRT Plus Systemic Therapy vs Systemic Therapy Alone in BCLC C Hepatocellular Carcinoma

Phase 2 Recruiting

Gastrointestinal

Carcinoma, Hepatocellular, Neoplasm Metastasis

NCT06333314 2025-12-02

Pan-MSI-ACSE

Phase 2 Recruiting

EndocrineSarcoma

Neoplasm Metastasis, Neoplasms, Sarcoma, Adrenocortical Carcinoma, Carcinoma, Neuroendocrine

NCT06846346 2025-11-28

GRACIE

Phase 2 Recruiting

Gastrointestinal

Adenocarcinoma Of Esophagus, Adenocarcinoma, Neoplasm Metastasis, Neoplasms

NCT07016230 2025-11-26

Study Investigating Tarlatamab (AMG 757) in Patients With Metastatic/Locally Advanced Small-Cell Lung Cancer (SCLC) and Other Poorly Differentiated Neuroendocrine Carcinomas (NECs), With Biomarker Analysis to Characterize Response/Resistance (UNLOCK TARLATAMAB)

Phase 2 Recruiting

Neoplasm Metastasis

NCT04116541 2025-11-21

MegaMOST

Phase 2 Recruiting

Neoplasm Metastasis

NCT05475171 2025-11-19

Triage of Advanced Cervical Cancer Through Immunotherapy Induction (TRACTION)

Phase 2 Recruiting

Uterine Cervical Neoplasms, Neoplasm Metastasis

NCT06246110 2025-11-12

A Phase 2 Study of EIK1001 in Combo With Pembrolizumab and Chemotherapy in Patients With Stage 4 NSCLC

Phase 2 Recruiting

Neoplasm Metastasis

NCT06601296 2025-11-12

SPARK

Phase 2 Recruiting

Bites and Stings, Carcinoma, Renal Cell, Neoplasm Metastasis, Neoplasms

NCT02710253 2025-11-10

Salvage Radiation Therapy in Treating Patients With Metastatic Cancer That Has Progressed After Systemic Immunotherapy

Phase 2 Recruiting

Other hematologic neoplasm

Neoplasm Metastasis, Hematologic Neoplasms

NCT04879121 2025-10-30

Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid Tumors

Phase 2 Recruiting

Neoplasm Metastasis

NCT05617716 2025-10-20

SPORTSMEN

Phase 2 Recruiting

Neoplasm Metastasis

NCT03915678 2025-10-06

AGADIR

Phase 2 Recruiting

BreastDermatologicGastrointestinalGenitourinaryThoracic

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms, Triple Negative Breast Neoplasms

NCT04807816 2025-10-02

TARSARC

Phase 2 Recruiting

Leiomyosarcoma, Neoplasm Metastasis, Sarcoma

NCT06397313 2025-09-23

POTAMI-61

Phase 2 Recruiting

Neoplasm Metastasis, Primary Myelofibrosis

NCT07070479 2025-09-18

Combination Therapy for PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Bayesian Adaptive Phase II Trial

Phase 2 Recruiting

Nasopharyngeal Carcinoma, Neoplasm Metastasis, Recurrence

NCT04874311 2025-08-13

TRUST

Phase 2 Recruiting

Tertiary Lymphoid Structures, Neoplasm Metastasis, Sarcoma

NCT02029001 2025-08-07

MOST plus

Phase 2 Recruiting

Neoplasm Metastasis

NCT05821556 2025-07-29

Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients

Phase 2 Recruiting

Neoplasm Metastasis

NCT06562348 2025-05-01

ctDNA-RECIST

Phase 2 Recruiting

Gastrointestinal

Gastrointestinal Neoplasms, Neoplasm Metastasis