Clinical Trials

2 enrolled

Nonseminomatous germ cell tumor, Neoplasms, Germ Cell and Embryonal

NCT03638167 2025-12-17

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

11 enrolled

CNSGastrointestinalGenitourinarySarcoma

Choroid Plexus Carcinoma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT02162732 2025-11-03

Molecular-Guided Therapy for Childhood Cancer

Phase NA Completed

186 enrolled 12 charts

Carcinoma, Renal Cell, Craniopharyngioma, Ependymoma, Glioma, Carcinoma, Hepatocellular, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Choroid Plexus Neoplasms, Sarcoma, Clear Cell, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT06341998 2025-09-19

SCRRYST

Phase 2/3 Completed

32 enrolled

Neoplasms, Germ Cell and Embryonal, Endodermal Sinus Tumor

NCT06470464 2025-09-18

Thalidomide Combined With Chemotherapy in the Treatment of Relapsed or Refractory Yolk Sac Tumor

20 enrolled

Neoplasms, Germ Cell and Embryonal, Recurrence, Endodermal Sinus Tumor

NCT03426865 2025-08-11

TESTPET

10 enrolled

BreastDermatologicOther hematologic neoplasm

Testicular Germ Cell Tumor, Neoplasms, Germ Cell and Embryonal, Teratoma, Testicular Diseases, Testicular Neoplasms, Endodermal Sinus Tumor

NCT04035447 2025-06-29

Symptom Management for YA Cancer Survivors

Phase NA Completed

65 enrolled 16 charts

Breast Neoplasms, Endocrine Gland Neoplasms, Fatigue, Melanoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Pain, Hematologic Neoplasms

NCT04743310 2025-06-13

Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System

50 enrolled

590 enrolled 58 charts 5 FDA

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Neuroma, Acoustic, Pinealoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT03037385 2025-05-31

ARROW

Phase 1/2 Completed

EndocrineGastrointestinalHead & NeckNETThoracic

Thyroid Cancer, Papillary, Adenocarcinoma, Adenocarcinoma, Papillary, Bronchial Neoplasms, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Colorectal Neoplasms, Neuroectodermal Tumors, Carcinoma, Medullary, Carcinoma, Neuroendocrine, Neuroendocrine Tumors, Multiple Endocrine Neoplasia Type 2a

NCT03507491 2024-10-04

Nab-paclitaxel in Combination with Gemcitabine for Pediatric Relapsed and Refractory Solid Tumors

CNSGastrointestinalGenitourinarySarcoma

24 enrolled

Neoplasms, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma

NCT01782339 2024-06-14

GAMMA

45 enrolled

Neoplasms, Germ Cell and Embryonal

NCT03434262 2024-05-31

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

68 enrolled

CNSLymphoid

Choroid Plexus Carcinoma, Microphthalmia, Isolated, with Coloboma 5, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Lymphoma, Follicular, Medulloblastoma, Meningioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pinealoma, Recurrence, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

NCT06309732 2024-03-13

GAMEC-II

36 enrolled

Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms

NCT03012620 2024-02-28

AcSé

CNSEndocrineGynecologicHead & NeckLymphoidSarcoma

334 enrolled

Neoplasms, Germ Cell and Embryonal, Ovarian Neoplasms, Sarcoma, Thyroid Neoplasms, Central Nervous System Neoplasms, Carcinoma, Neuroendocrine, Lymphoma, Extranodal NK-T-Cell

NCT01505569 2024-02-26

Auto Transplant for High Risk or Relapsed Solid or CNS Tumors

Phase NA Completed

44 enrolled

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Brain Neoplasms, Carcinoma, Renal Cell, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Rhabdoid Tumor

NCT02457845 2024-01-19

HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors

13 enrolled

CNSSarcoma

Choroid Plexus Carcinoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Virus Diseases, Supratentorial Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma, Rhabdoid Tumor

NCT02571036 2023-12-13

A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies

CNSDermatologicGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmSarcomaThoracic

282 enrolled

Mast Cell Activation Disorders, Carcinoma, Non-Small-Cell Lung, Glioma, Leukemia, Mast-Cell, Melanoma, Neoplasms, Germ Cell and Embryonal, Penile Neoplasms, Sarcoma, Mastocytosis, Systemic, Gastrointestinal Stromal Tumors, Renal Insufficiency

NCT02303015 2023-11-21

Toxicity Attributed to Genetic Polymorphisms in Testicular Germ Cell Tumor Survivors

430 enrolled

Cardiovascular Diseases, Neoplasms, Germ Cell and Embryonal, Renal Insufficiency

NCT03950830 2023-10-04

DISGCT

12 enrolled

Neoplasms, Germ Cell and Embryonal

NCT03194906 2023-07-13

Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors

34 enrolled

Brain Neoplasms, Craniopharyngioma, Ependymoma, Neoplasms, Germ Cell and Embryonal

NCT04657315 2023-01-18

MSC11FCD-GBM

Phase 1/2 Completed

10 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Neoplasms, Germ Cell and Embryonal, Central Nervous System Neoplasms, Gliosarcoma

NCT04283773 2021-09-08

Immunohistochemical Evaluation of Protein P16 Expression in Ovarian Germ Cell Tumors.

62 enrolled 10 charts

Gynecologic

Neoplasms, Germ Cell and Embryonal, Ovarian Neoplasms

NCT00864318 2021-01-12

TICE

101 enrolled

Neoplasms, Germ Cell and Embryonal, Recurrence

NCT02300987 2020-10-26

A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression

10 enrolled 12 charts

Neoplasms, Germ Cell and Embryonal, Teratoma

NCT02429466 2020-09-23

Study of the Hypomethylating Drug Guadecitabine (SGI-110) Plus Cisplatin in Relapsed Refractory Germ Cell Tumors

14 enrolled

Testicular Germ Cell Tumor, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms

NCT02414685 2020-08-07

TIP

19 enrolled

Neoplasms, Germ Cell and Embryonal

NCT00179803 2020-08-05

Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors

24 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Supratentorial Neoplasms, Central Nervous System Neoplasms, Rhabdoid Tumor

NCT01331135 2020-05-29

Aflac ST0901

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

18 enrolled

Astrocytoma, Carcinoma, Renal Cell, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Recurrence, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT02390843 2020-04-03

AflacST1402

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

13 enrolled

Carcinoma, Renal Cell, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT00340522 2019-12-16

Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development

20 enrolled

CNSSarcoma

Brain Neoplasms, Neoplasms, Neoplasms, Germ Cell and Embryonal, Sarcoma, Neurofibroma, Plexiform

NCT03403777 2019-03-05

Avelumab in Refractory Testicular Germ Cell Cancer.

8 enrolled

Gonadal Disorders, Neoplasms, Neoplasms, Germ Cell and Embryonal, Testicular Diseases, Testicular Neoplasms

NCT01682746 2019-02-25

Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors

5 enrolled

CNSEndocrineSarcoma

Astrocytoma, Brain Neoplasms, Chordoma, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pituitary Neoplasms, Germinoma, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Optic Nerve Glioma

NCT02679950 2018-08-08

Understanding the Molecular and Genetic Differences Between Germ Cell Tumor at the Time of the Initial Diagnosis and at Late Relapse

6 enrolled

Neoplasms, Germ Cell and Embryonal

NCT01851200 2018-02-07

Brentuximab Vedotin (SGN-35) as Salvage Treatment for CD30-positive Germ Cell Tumors

9 enrolled

Neoplasm Metastasis, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms, Carcinoma, Embryonal

NCT01177007 2017-08-28

Intra-arterial Y-90 TheraSpheres for Hepatic Metastases From Solid Tumors

EndocrineGastrointestinalNET

50 enrolled 10 charts

Adenocarcinoma, Carcinoma, Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Liver Diseases, Liver Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Neoplastic Processes, Pathologic Processes, Rectal Diseases, Colorectal Neoplasms, Neuroectodermal Tumors, Carcinoma, Neuroendocrine, Neuroendocrine Tumors

NCT00183820 2017-07-07

Study of Gemcitabine, Oxaliplatin, and Paclitaxel in Patients With Refractory Germ Cell Carcinoma

30 enrolled

Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms

NCT01736917 2016-05-25

Fosaprepitant + 5HT3 Receptor Antagonists + Dexamethasone in Germ Cell Tumors

65 enrolled 14 charts

Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms, Vomiting

NCT00572572 2016-04-06

Aprepitant + a 5HT3 + Dexamethasone in Patients With Germ Cell Tumors

Phase 3 Completed

69 enrolled 14 charts

Neoplasms, Germ Cell and Embryonal

NCT00393861 2016-03-24

Study of Oxaliplatin Plus Bevacizumab in Germ Cell Tumor Patients

29 enrolled 10 charts

Neoplasms, Germ Cell and Embryonal

NCT01466231 2016-01-12

Everolimus in Refractory Testicular Germ Cell Cancer

15 enrolled

Neoplasms, Germ Cell and Embryonal

NCT00753415 2015-03-17

A Study of V934/V935 Vaccine in Cancer Participants With Selected Solid Tumors (V934-002)