Clinical Trials

Neoplasms, Unknown Primary

NCT03752333 2026-01-22

CUPem

35 enrolled

Phase 2 Active not recruiting

Neoplasms, Unknown Primary

NCT02713269 2025-10-30

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

60 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasms, Unknown Primary, Sarcoma, Spinal Cord Compression, Thyroid Neoplasms

NCT04475640 2025-10-30

Cancer Genetic Testing in Ethnic Populations

Phase NA Recruiting

1,800 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasms, Unknown Primary

NCT04273061 2025-09-22

CAPTIV-8

Phase 2 Recruiting

200 enrolled

BreastDermatologicGastrointestinalHead & NeckSarcomaThoracic

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Neoplasms, Unknown Primary, Sarcoma, Skin Neoplasms, Urogenital Neoplasms

NCT03391973 2025-04-25

CUP

Phase 2 Active not recruiting

26 enrolled

Neoplasms, Unknown Primary

NCT05576974 2025-04-08

A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)

Phase 2 Recruiting

120 enrolled

Phase NA Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Unknown Primary

NCT04584008 2024-10-15

VISIONARY

600 enrolled

EndocrineGastrointestinalNETSarcoma

Esophageal Squamous Cell Carcinoma, Biliary Tract Neoplasms, Gastrointestinal Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors

NCT04504604 2024-08-09

TRACK

Phase NA Recruiting

400 enrolled

Neoplasms, Unknown Primary, Cholangiocarcinoma

NCT05841966 2024-05-07

OP-CUP

Phase NA Completed

30 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

Carcinoma, Squamous Cell, Neoplasms, Unknown Primary

NCT01624220 2023-12-05

A Prospective Study Using Implanted Fiducial Markers to Assess Treatment Accuracy and Esophageal Toxicity in Spinal Stereotactic Body Radiation Therapy

Phase NA Completed

41 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasms, Unknown Primary, Prostatic Neoplasms, Sarcoma, Spinal Cord Neoplasms, Thyroid Neoplasms

NCT04456140 2023-07-24

Pro-Active Genetic Testing in Patients With Solid Tumors, Inherit Study

BreastCNSGastrointestinalHead & Neck

230 enrolled

Brain Neoplasms, Breast Neoplasms, Digestive System Neoplasms, Head and Neck Neoplasms, Neoplasms, Unknown Primary, Urogenital Neoplasms, Central Nervous System Neoplasms

NCT00499291 2023-05-25

Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced or Refractory Solid Tumors

Phase NA Withdrawn

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Teratoma, Testicular, Teratoma, Ovarian, Carcinoma, Ovarian Epithelial, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Stomach Neoplasms, Teratoma, Testicular Neoplasms, Endometrial Neoplasms, Small Cell Lung Carcinoma

NCT01845337 2023-05-12

TOFFEE

59 enrolled

Bile Duct Neoplasms, Gastrointestinal Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms

NCT05263700 2023-03-31

FAPI-CUP

Phase NA Unknown

150 enrolled

Neoplasms, Unknown Primary

NCT04189107 2023-03-16

Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP & OSAS

18 enrolled

CNSDermatologicEndocrineNET

Agnosia, Head and Neck Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Pain, Postoperative

NCT04276597 2023-03-10

PUTNET

Phase 2 Withdrawn

Neoplasms, Unknown Primary, Paraganglioma, Pheochromocytoma, Carcinoma, Merkel Cell, Neuroendocrine Tumors

NCT03278600 2022-01-24

Tissue-of-origin Directing Therapy in Patients With Cancer of Unknown Primary

182 enrolled

Neoplasms, Unknown Primary

NCT00003526 2020-12-17

Antineoplaston Therapy in Treating Patients With Cancer of Unknown Primary Origin

Phase 2 Terminated

8 enrolled 5 charts

Neoplasms, Unknown Primary

NCT00357630 2020-11-02

Gemcitabine in Treating Patients With Metastatic Cancer of Unknown Primary

52 enrolled

Neoplasms, Unknown Primary, Pain

NCT01643499 2020-05-08

Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies

79 enrolled

Bile Duct Neoplasms, Colonic Neoplasms, Gallbladder Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT04131621 2020-04-15

CheCUP

Phase 2 Unknown

194 enrolled

Neoplasms, Unknown Primary

NCT01540058 2020-02-17

GEFCAPI04

243 enrolled

Neoplasms, Unknown Primary

NCT03628079 2020-01-22

RepoMeb

Phase 1/2 Terminated

11 enrolled

Gastrointestinal Neoplasms, Neoplasms, Unknown Primary

NCT02764216 2019-04-09

Elective Mucosal Irradiation in Head-and-Neck Cancer of Unknown Primary

Phase 2 Unknown

48 enrolled

Phase EARLY_PHASE1 Terminated

Head and Neck Neoplasms, Neoplasms, Unknown Primary

NCT00499733 2019-01-18

Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer

19 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckLymphoidSarcomaThoracic

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Chondrosarcoma, Colonic Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Osteosarcoma, Tongue Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Esthesioneuroblastoma, Olfactory, Breast Neoplasms, Male, Small Cell Lung Carcinoma, Intraocular Lymphoma

NCT02966509 2018-10-31

EPAC

Phase NA Completed

213 enrolled 20 charts

CNSDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Colonic Neoplasms, Death, Glioblastoma, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Unknown Primary, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Testicular Neoplasms

NCT00003867 2018-09-10

Irinotecan and Capecitabine in Treating Patients With Solid Tumors

30 enrolled

BreastGastrointestinal

Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT00047125 2018-07-09

Radiation Therapy in Treating Patients With Metastases to the Lymph Nodes in the Neck From an Unknown Primary Tumor

600 enrolled

Neoplasms, Unknown Primary

NCT00004005 2017-04-26

Irinotecan Followed By Fluorouracil and Leucovorin in Treating Patients With Stage III or Stage IV Colorectal Carcinoma (Cancer), Other Refractory Carcinoma, or Metastatic Adenoma (Cancer) of Unknown Primary Origin

12 enrolled

Colonic Neoplasms, Neoplasms, Unknown Primary, Rectal Neoplasms, Colorectal Neoplasms

NCT00066781 2017-04-04

Gemcitabine and Irinotecan in Treating Patients With Cancer of Unknown Primary

31 enrolled 8 charts

Neoplasms, Unknown Primary

NCT00936702 2017-03-21

Carboplatin, Paclitaxel, and Everolimus in Treating Patients With Previously Untreated Cancer of Unknown Primary

46 enrolled 13 charts

Neoplasms, Unknown Primary

NCT00003657 2017-01-20

High-dose ICE With Amifostine

CNSGenitourinaryGynecologicHead & NeckSarcomaThoracic

24 enrolled

AIDS-related Kaposi sarcoma, Testicular Germ Cell Tumor, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Chondrosarcoma, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Neoplasms, Unknown Primary, Ovarian Neoplasms, Sarcoma, Sarcoma, Kaposi, Osteosarcoma, Testicular Neoplasms, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Esthesioneuroblastoma, Olfactory, Small Cell Lung Carcinoma

NCT00003582 2016-12-15

Radiation Therapy, Combination Chemotherapy, and Amifostine in Treating Patients With Head and Neck Cancer

Phase 1/2 Completed

36 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Unknown Primary

NCT00201734 2016-09-23

Capecitabine, Carboplatin and Weekly Paclitaxel for Patients With Solid Tumors and Adenocarcinoma of Unknown Primary

Phase 1/2 Terminated

57 enrolled 11 charts

Adenocarcinoma, Neoplasms, Neoplasms, Unknown Primary

NCT00873119 2015-07-28

Belinostat, Carboplatin and Paclitaxel (BelCaP) Compared to Carboplatin and Paclitaxel in Patients With Cancer of Unknown Primary

89 enrolled 12 charts

Neoplasms, Unknown Primary

NCT00458315 2015-05-08

Cisplatin/Paclitaxel/Gemcitabine +/- Avastin in Patients With Unknown Primary Tumor

Phase 2 Withdrawn

Neoplasms, Unknown Primary

NCT02327065 2014-12-30

Prospective Multi-center, Single Blinded, Randomized, Controlled Trial of EUS-FNB and EUS-FNA on Solid Occupying Lesion

Phase NA Unknown

408 enrolled

Lymphatic Metastasis, Neoplasm Metastasis, Neoplasms, Unknown Primary, Pancreatic Neoplasms

NCT00360360 2013-12-04

Paclitaxel/Carboplatin Plus Bevacizumab/Erlotinib in the First Line Treatment of Carcinoma of Unknown Primary Site

60 enrolled 6 charts

Neoplasms, Unknown Primary

NCT00193609 2013-11-11

Oxaliplatin and Capecitabine in the Treatment of Relapsed/Refractory Carcinoma of Unknown Primary Site

48 enrolled 6 charts

Neoplasms, Unknown Primary

NCT00022178 2013-09-20

Combination Chemotherapy in Treating Patients With Metastatic Cancer of an Unknown Site of Origin

Phase 3 Unknown

Neoplasms, Unknown Primary

NCT00014456 2013-08-28

Combination Chemotherapy Plus Filgrastim in Treating Patients With Advanced Solid Tumors

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

35 enrolled

AIDS-related Kaposi sarcoma, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Chondrosarcoma, Esophageal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Unknown Primary, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Sarcoma, Kaposi, Osteosarcoma, Stomach Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Esthesioneuroblastoma, Olfactory, Small Cell Lung Carcinoma

NCT00003558 2013-08-07

Chemotherapy in Treating Patients With Cancer of Unknown Primary Origin

Phase 3 Unknown

140 enrolled

Neoplasms, Unknown Primary

NCT00002507 2013-07-25

Radiation Therapy and Chemotherapy in Treating Patients With Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Unknown Primary

NCT00004922 2013-06-19

Irinotecan in Treating Patients With Advanced Neuroendocrine Tumors

DermatologicEndocrine

Neoplasms, Unknown Primary, Carcinoma, Merkel Cell, Carcinoma, Neuroendocrine

NCT00193596 2013-05-03

Gemcitabine/Irinotecan/ZD1839 vs Paclitaxel/Carboplatin/Etoposide/ZD1839 in Carcinoma of Unknown Primary Site

198 enrolled 7 charts

Neoplasms, Unknown Primary

NCT00003943 2013-04-17

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Cancer.

3 enrolled

Thoracic

Lung Neoplasms, Neoplasms, Unknown Primary

NCT00004074 2013-02-28

Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu