NCT02034110 2023-08-21Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare CancersNovartisPhase 2 Completed206 enrolled 40 charts 2 FDA
NCT01336634 2022-04-04Study of Selective BRAF Kinase Inhibitor Dabrafenib Monotherapy Twice Daily and in Combination With Dabrafenib Twice Daily and Trametinib Once Daily in Combination Therapy in Subjects With BRAF V600E Mutation Positive Metastatic (Stage IV) Non-small Cell Lung Cancer.NovartisPhase 2 Completed177 enrolled 19 charts 1 FDA
NCT02083354 2022-02-01Study to Investigate the Objective Response Rate of Dabrafenib in Combination With Trametinib in Subjects With BRAF V600 Mutation-Positive MelanomaNovartisPhase 2 Completed77 enrolled 43 charts
NCT01072175 2019-07-05Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212NovartisPhase 2 Completed430 enrolled 61 charts
NCT02314143 2019-02-18Phase II Biomarker Study Comparing the Combination of BRAF Inhibitor Dabrafenib With MEK Inhibitor Trametinib Versus the Combination After Monotherapy With Dabrafenib or TrametinibGlaxoSmithKlinePhase 2 Terminated48 enrolled 20 charts
NCT01227889 2017-10-04A Study Comparing GSK2118436 to Dacarbazine (DTIC) in Previously Untreated Subjects With BRAF Mutation Positive Advanced (Stage III) or Metastatic (Stage IV) MelanomaGlaxoSmithKlinePhase 3 Completed251 enrolled 21 charts