Clinical Trials

CNSEndocrineGastrointestinalGynecologicNETOther solid neoplasmSarcomaThoracic

40 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Meningioma, Neoplasms, Neuroblastoma

NCT02611024 2025-07-09

Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors

Phase 1/2 Completed

316 enrolled

Gastro-enteropancreatic neuroendocrine tumor, Carcinoma, Ovarian Epithelial, Glioblastoma, Mesothelioma, Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Neuroendocrine Tumors

NCT02885753 2025-07-09

OSCAR

Phase 3 Recruiting

348 enrolled

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT01550510 2025-05-06

Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA

4 enrolled 5 charts

Phase 2 Active not recruiting

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT03709680 2025-01-14

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

128 enrolled

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Bone Neoplasms, Medulloblastoma, Neoplasms, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Rhabdoid Tumor

NCT03678883 2024-11-07

9-ING-41 in Patients with Advanced Cancers

Phase 2 Active not recruiting

350 enrolled

BreastCNSGastrointestinalGenitourinaryLymphoidOther hematologic neoplasmSarcomaThoracic

Bone Neoplasms, Breast Neoplasms, Glioma, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Neoplasms, Hereditary Sensory and Autonomic Neuropathies, Pancreatic Neoplasms, Sarcoma, Colorectal Neoplasms, Leukemia-Lymphoma, Adult T-Cell

NCT04525014 2024-10-31

PIRATE

2 enrolled

CNS

Brain Neoplasms, Neoplasms, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT02842580 2024-07-10

HIGH-LIGHT

21 enrolled 12 charts

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT00838578 2024-04-26

Phase I/II Study of KRN330 Plus Irinotecan in Patients With Metastatic Colorectal Cancer

65 enrolled 7 charts

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT02085148 2024-04-22

A Phase I Dose Finding Study in Children With Solid Tumors Recurrent or Refractory to Standard Therapy

CNSGastrointestinalGenitourinarySarcoma

62 enrolled

Neoplasms, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Hepatoblastoma

NCT02753127 2023-11-15

CanStem303C

Phase 3 Completed

1,253 enrolled 18 charts

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Rectal Diseases, Colorectal Neoplasms

NCT01726582 2023-08-14

Pancreas Cancer: Molecular Profiling as a Guide to Therapy Before and After Surgery ("Personalized Medicine")

229 enrolled 14 charts

Adenocarcinoma, Neoplasms, Pancreatic Neoplasms

NCT00060567 2023-06-18

Dose-Finding Study of E7070 in Combination With Irinotecan

88 enrolled

Neoplasms

NCT03495921 2023-04-26

VITA

Phase 3 Terminated

32 enrolled 13 charts

Sarcoma

Neoplasms, Neoplasms by Histologic Type, Neoplasms, Connective Tissue, Sarcoma, Sarcoma, Ewing, Neoplasms, Connective and Soft Tissue, Neoplasms, Bone Tissue, Neuroectodermal Tumors, Primitive, Peripheral, Rare Diseases

NCT01528046 2023-01-13

Metformin in Children With Relapsed or Refractory Solid Tumors

26 enrolled

CNS

Brain Neoplasms, Neoplasms, Recurrence

NCT03665441 2022-10-18

Trybeca-1

Phase 3 Completed

512 enrolled 19 charts

Neoplasms

NCT01660711 2021-11-08

A Pilot Study of Pre- and Post-surgery Chemotherapy With mFOLFIRINOX in Localized, Resectable Pancreatic Adenocarcinoma

22 enrolled 8 charts

Adenocarcinoma, Neoplasms

NCT03368859 2021-02-09

A Study of ABT-165 Plus FOLFIRI vs Bevacizumab Plus FOLFIRI in Subjects With Metastatic Colorectal Cancer Previously Treated With Fluoropyrimidine, Oxaliplatin and Bevacizumab

70 enrolled 12 charts

Intestinal Neoplasms, Neoplasms, Colorectal Neoplasms

NCT03096340 2020-12-22

Safety and Pharmacokinetic Study of IT-141 in Monotherapy in Patients With Advanced Cancer

10 enrolled

Neoplasms

NCT01858649 2020-10-22

BEV-ONCO2012

60 enrolled

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT00062842 2020-03-04

Study of Irinotecan on a Weekly Schedule in Children

23 enrolled

Neoplasms

NCT01653470 2020-01-28

Study to Evaluate Safety & Tolerability of BMS-906024 in Combination With Chemotherapy & to Define DLTs & MTD of BMS-906024 in Combination With One of the Following Chemotherapy Regimens; Weekly Paclitaxel, 5FU+Irinotecan or Carboplatin+Paclitaxel in Subjects With Advanced / Metastatic Solid Tumors

141 enrolled

Neoplasms

NCT01479465 2019-04-17

Efficacy and Safety of Simtuzumab (SIM) With FOLFIRI as Second Line Treatment in Colorectal Adenocarcinoma

266 enrolled 15 charts

Neoplasms, Colorectal Neoplasms

NCT01274624 2018-12-19

Study of REOLYSIN® in Combination With FOLFIRI and Bevacizumab in FOLFIRI Naive Patients With KRAS Mutant Metastatic Colorectal Cancer

36 enrolled

Neoplasms

NCT00418938 2018-10-17

SPIRITT - Second-Line Panitumumab Irinotecan Treatment Trial

266 enrolled 17 charts

Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02620423 2018-09-13

Study of Pembrolizumab With REOLYSIN® and Chemotherapy in Patients With Advanced Pancreatic Adenocarcinoma

11 enrolled

Neoplasms

NCT00003867 2018-09-10

Irinotecan and Capecitabine in Treating Patients With Solid Tumors

30 enrolled

BreastGastrointestinal

Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT00816777 2018-09-07

PARAGON

4 enrolled 5 charts

Carcinoma, Colonic Neoplasms, Gastrointestinal Neoplasms, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT00960063 2018-08-27

A Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Pediatric Participants With Advanced Solid Tumors (P05883, MK-7454-006)

4 enrolled 8 charts

CNSGenitourinarySarcoma

Bone Neoplasms, Carcinoma, Renal Cell, Neoplasms, Neuroblastoma

NCT00954512 2018-08-24

Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Participants With Advanced Solid Tumors (P04722, MK-7454-004)

15 enrolled 11 charts

Neoplasms

NCT02241551 2018-07-26

Phase II Neoadjuvant Chemotheraphy (Gemcitabine and Nab-Paclitaxel vs. mFOLFIRINOX) and Sterotatic Body Radiation Therapy for Borderline Resectable Pancreatic Cancer

2 enrolled 7 charts

Neoplasms

NCT01520389 2018-03-21

Safety Study of the Drug MM-151 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment

BreastGastrointestinalHead & NeckThoracic

112 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT00682786 2017-10-06

Genotype-directed Neoadjuvant Chemoradiation for Rectal Carcinoma

135 enrolled 17 charts

Carcinoma, Neoplasms, Rectal Neoplasms

NCT01383538 2017-08-08

FOLFIRINOX Plus IPI-926 for Advanced Pancreatic Adenocarcinoma

15 enrolled

Adenocarcinoma, Neoplasms, Pancreatic Neoplasms

NCT02316496 2017-08-01

REGAIN

2 enrolled

Neoplasm Metastasis, Neoplasms

NCT00400114 2017-05-08

Sutent Following Chemotherapy, Radiation and Surgery For Resectable Esophageal Cancer

36 enrolled

Esophageal Neoplasms, Neoplasms

NCT00143533 2017-04-26

Prevention of Diarrhea in Patients Taking IV Irinotecan for Relapsed or Difficult to Treat Pediatric Solid Tumors

20 enrolled

Diarrhea, Neoplasms

NCT02640365 2017-01-31

DOUBLIRI

10 enrolled

Neoplasms

NCT00416767 2016-05-30

Combination Chemotherapy as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors of the Duodenum or Pancreas That Cannot Be Removed By Surgery