Clinical Trials

Phase 2 Active not recruiting

Adenocarcinoma, Neoplasms

NCT04795661 2026-01-07

IMHOTEP

240 enrolled

DermatologicHead & NeckSarcoma

Neoplasms

NCT05859074 2025-12-03

A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

Phase 1 Recruiting

56 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Hemangiosarcoma, Melanoma, Neoplasm Metastasis, Neoplasms, Paget Disease, Extramammary, Sarcoma, Kaposi, Skin Neoplasms, Carcinoma, Merkel Cell, Adenocarcinoma, Sebaceous, Carcinoma, Skin Appendage

NCT04964960 2025-10-31

Pembro+Chemo in Brain Mets

Phase 2 Terminated

3 enrolled 7 charts

CNSThoracic

Brain Neoplasms, Lung Neoplasms, Neoplasms

NCT05064280 2025-10-09

Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases

Phase 2 Recruiting

104 enrolled

CNS

Brain Neoplasms, Neoplasms

NCT05714553 2025-07-18

NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours

Phase 1/2 Terminated

19 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Esophageal Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT06031233 2025-05-21

MINUTE

Phase 4 Recruiting

679 enrolled

Phase 2 Active not recruiting

Neoplasms

NCT03632941 2025-03-12

A Study to Evaluate Concurrent VRP-HER2 Vaccination and Pembrolizumab for Patients With Breast Cancer

8 enrolled 13 charts

Breast

Breast Neoplasms, Neoplasms

NCT03153410 2025-01-09

Pilot Study With CY, Pembrolizumab, GVAX, and IMC-CS4 (LY3022855) in Patients With Borderline Resectable Adenocarcinoma of the Pancreas

Phase EARLY_PHASE1 Completed

11 enrolled 14 charts

Phase 1 Active not recruiting

Adenocarcinoma, Neoplasms, Pancreatic Neoplasms

NCT03568058 2024-11-13

Personalized Immunotherapy in Adults With Advanced Cancers Immunotherapy in Adults With Advanced Cancers

30 enrolled

Neoplasms

NCT04924374 2024-09-26

Microbiota Transplant in Advanced Lung Cancer Treated With Immunotherapy

Phase NA Completed

25 enrolled

Lung Neoplasms, Neoplasms

NCT06607393 2024-09-23

CARE Initiative: Real-world Emulation of the KEYNOTE-189 Trial [DS3]

851 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT06585189 2024-09-05

CARE Initiative: Real-world Emulation of the KEYNOTE-189 Trial [DS4]

304 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT04510636 2024-03-22

Study of Pembrolizumab With Bendamustine in Hodgkin Lymphoma

Phase 2 Recruiting

37 enrolled

Neoplasms, Recurrence

NCT03349450 2023-11-02

SPiReL

Phase 2 Completed

25 enrolled

LymphoidSarcoma

Immune System Diseases, Immunoproliferative Disorders, Lymphatic Diseases, Lymphoma, Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Neoplasms, Neoplasms by Histologic Type, Recurrence, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Dendritic Cell Sarcoma, Interdigitating

NCT02313272 2023-10-23

Hypofractionated Stereotactic Irradiation (HFSRT) With Pembrolizumab and Bevacizumab for Recurrent High Grade Gliomas

Phase 1 Completed

32 enrolled 12 charts

CNS

Glioma, Neoplasms, Neurologic Manifestations

NCT05908799 2023-09-13

Emulation of the KEYNOTE-189 Trial Using Electronic Health Records

1,854 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms

NCT02858921 2023-08-30

Neo Trio

Phase 2 Unknown

60 enrolled

Dermatologic

Melanoma, Neoplasms

NCT04258683 2023-08-29

A Study of Pembrolizumab Added to the Standard First-Line Therapy of Cyclophosphamide, Bortezomib, and Dexamethasone (CyBorD) for NDMM NTE

Phase 2 Withdrawn

Plasma cell

Cardiovascular Diseases, Hematologic Diseases, Immune System Diseases, Multiple Myeloma, Neoplasms

NCT06000358 2023-08-21

LUCACRIMUNO

Phase NA Recruiting

120 enrolled

BreastGastrointestinalGynecologicThoracic

Lung Neoplasms, Neoplasms

NCT05431582 2023-06-15

Phase I Study of ZN-c3 and Bevacizumab ± Pembrolizumab in Metastatic CCNE1 Amplified and TP53 Mutant Solid Tumors

Phase 1 Withdrawn

Breast Neoplasms, Lung Neoplasms, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms

NCT04801966 2023-05-10

TAILOR

Phase NA Terminated

3 enrolled

Neoplasms

NCT05175235 2023-03-03

Nivolumab and Pembrolizumab Dose Optimisation in Solid Tumours With CURATE.AI Platform and Sequential ctDNA Measurements

Phase 1/2 Unknown

10 enrolled

Neoplasms

NCT02909348 2023-03-02

PASIP

25 enrolled

Dermatologic

Melanoma, Neoplasms

NCT05322187 2022-04-11

sPLENTY-pc

Phase 2/3 Unknown

15 enrolled

Liver Neoplasms, Neoplasms, Hepatoblastoma

NCT02303990 2021-05-12

RADVAX: A Stratified Phase I Trial of Pembrolizumab With Hypofractionated Radiotherapy in Patients With Advanced and Metastatic Cancers

Phase 1 Completed

59 enrolled 9 charts

Neoplasms

NCT03832673 2021-02-26

PECULIAR

Phase 2 Withdrawn

Neoplasms

NCT02981524 2021-02-10

Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal Cancer

Phase 2 Completed

17 enrolled 12 charts

Other hematologic neoplasm

Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Neoplasms, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT04016116 2020-05-27

Dual PD-1 and JAK2 Inhibition in Hematological Malignancies

Phase 2 Withdrawn

Neoplasms, Hematologic Neoplasms

NCT03634332 2019-05-07

Second-line Study of PEGPH20 and Pembro for HA High Metastatic PDAC

Phase 2 Unknown

35 enrolled