Clinical Trials Browser

Astrocytoma, Ganglioneuroma, Glioblastoma, Glioma, Histiocytosis, Langerhans-Cell, Neuroblastoma, Neurofibromatosis 1, Oligodendroglioma, Ganglioglioma, Neurocytoma, Neurofibroma, Plexiform

NCT04590235 2026-01-30

A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

Phase 1 Active not recruiting

32 enrolled

CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT05363267 2026-01-13

NF-1, Nutraceutical Intervention

Phase 1 Active not recruiting

23 enrolled

CNS

Neurofibromatosis 1

NCT04924608 2026-01-12

KOMET

Phase 3 Active not recruiting

145 enrolled 17 charts 1 FDA

CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT05677594 2026-01-12

Multi-parametric Biomarker Development to Predict Malignant Conversion in Patients With Neurofibromatosis Type 1

Active not recruiting

80 enrolled

CNSSarcoma

Disease, Neurofibromatosis 1, Neurofibrosarcoma

NCT05309668 2025-12-18

SPRINKLE

Phase 1/2 Active not recruiting

36 enrolled 37 charts

CNS

Neurofibromatosis 1

NCT05581511 2025-10-14

cNF Natural Hx

Active not recruiting

500 enrolled

CNS

Neurofibroma, Neurofibromatosis 1, Neurofibromatoses

NCT03962543 2025-08-07

ReNeu

Phase 2 Active not recruiting

114 enrolled 25 charts 1 FDA

CNS

Neurofibroma, Neurofibromatosis 1, Neurofibromatoses, Neurofibroma, Plexiform

NCT02964884 2025-06-24

Interventions for Reading Disabilities in NF1

Phase 2 Active not recruiting

120 enrolled

CNS

Dyslexia, Learning Disabilities, Neurofibromatosis 1

Clinical Trials

Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma

A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma

PASS of Paediatric Patients Initiating Selumetinib

Natural History Study of Patients With Neurofibromatosis Type I

MEK 1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

Pediatric Long-Term Follow-up and Rollover Study