Clinical Trials Browser

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT04295759 2026-01-05

INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

Phase 1 Completed

13 enrolled 15 charts

CNS

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Pyloric Stenosis, Hypertrophic

NCT04541082 2025-12-18

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Phase 1 Recruiting

102 enrolled

CNSSarcoma

Typical Teratoid Rhabdoid Tumor, Astrocytoma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma

NCT07031765 2025-12-18

Peds CHAMP1ON

Phase 1 Active not recruiting

12 enrolled

CNS

Astrocytoma, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma

NCT02192359 2025-11-14

Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas

Phase 1 Active not recruiting

18 enrolled 16 charts

CNSSarcoma

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02381886 2025-11-10

A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations

Phase 1 Active not recruiting

166 enrolled

CNSGastrointestinalMyeloidOther hematologic neoplasm

Astrocytoma, Glioblastoma, Glioma, Leukemia, Myelodysplastic Syndromes, Oligodendroglioma, Leukemia, Myeloid, Acute, Cholangiocarcinoma

NCT05698524 2025-05-20

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

Phase 1 Recruiting

24 enrolled

CNSSarcoma

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02186509 2025-04-30

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas

Phase 1 Completed

17 enrolled 11 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

Clinical Trials

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive IDH-1 Mutant Glioma

ADAGiO

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

rQNestin

Clinical Trial Evaluating Safety of 5-Aminolevulinic Acid (5-ALA) Combined With CV01 Delivery of Ultrasound for Sonodynamic Therapy (SDT) in Patients With Newly Diagnosed High-Grade Glioma (HGG) Prior to Resection and Standard Adjuvant Therapy (ALA SDT GLIOMA 401)

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Peds CHAMP1ON

Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas

A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas