Clinical Trials

55 enrolled 10 charts

Laryngeal Diseases, Oropharyngeal Neoplasms

NCT03258554 2026-02-06

Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin

Phase 2/3 Completed

196 enrolled 31 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03082534 2026-01-28

Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

78 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Neoplasm Metastasis, Oropharyngeal Neoplasms, Recurrence

NCT04580446 2025-12-15

HYHOPE: De-intensified Hypofractionated Radiation Therapy for HPV-associated Oropharynx Cancer

Phase 1 Completed

24 enrolled 17 charts

Oropharyngeal Neoplasms

NCT05055206 2025-12-03

Study of Lymphatic Drainage Mapping in Oropharyngeal Cancers

12 enrolled

Oropharyngeal Neoplasms

NCT02918955 2025-11-20

UPFRONT-NECK

65 enrolled

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Oropharyngeal Neoplasms

NCT02586207 2025-10-07

Pembrolizumab in Combination With CRT for LA-SCCHN

Phase 1 Completed

59 enrolled 9 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Diseases, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT02792322 2025-06-04

Robotic Surgery in the Seated Position for Benign and Malignant Lesions of the Head and Neck

32 enrolled

Head and Neck Neoplasms, Neoplasms, Oropharyngeal Neoplasms

NCT03416153 2025-05-22

Individualized Adaptive De-escalated Radiotherapy for HPV-related Oropharynx Cancer

91 enrolled 11 charts

Oropharyngeal Neoplasms

NCT04788264 2025-05-22

Exercise Training and Behavioral Modification for the Improvement of Physical Activity in Head and Neck Cancer Patients Undergoing Cancer Treatment

12 enrolled

Head & NeckThoracic

Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Lung Neoplasms, Maxillary Sinus Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Paranasal Sinus Neoplasms

NCT03838263 2025-03-04

IMMUNEBOOST

62 enrolled

Oropharyngeal Neoplasms

NCT03715946 2025-01-13

Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer

40 enrolled 69 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT02281955 2025-01-07

De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study

115 enrolled 18 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT01530997 2024-11-13

De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca

45 enrolled 22 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT05369234 2024-10-10

Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis

GastrointestinalHead & Neck

100 enrolled

Esophageal Neoplasms, Laryngeal Neoplasms, Mediastinal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05696314 2024-10-03

SPOT-US

201 enrolled

Oropharyngeal Neoplasms, Tonsillar Neoplasms

NCT03422536 2024-09-04

Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma

78 enrolled 16 charts

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Lip Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03077243 2024-05-02

P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC

195 enrolled 19 charts

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT03329950 2024-03-28

A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies

Phase 1 Completed

132 enrolled

Bile Duct Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Esophageal Neoplasms, Fallopian Tube Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Melanoma, Mouth Neoplasms, Oropharyngeal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Lymphoma, Large B-Cell, Diffuse, Cholangiocarcinoma, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Hyper-IgM Immunodeficiency Syndrome

NCT02703493 2024-03-12

Image-Guided Stereotactic Radiosurgery (SRS) Boost for HPV-Oropharyngeal Cancer

39 enrolled

Oropharyngeal Neoplasms

NCT04489212 2024-02-08

Study of Mucosal Sparing Adjuvant Radiotherapy After Surgical Exploration in HPV+ Head and Neck Cancer of Unknown Primaries

2 enrolled

Oropharyngeal Neoplasms

NCT02757222 2023-12-28

INTELHOPE

100 enrolled

Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Oropharyngeal Neoplasms

NCT02784288 2023-06-27

Phase II Treatment Stratification Trial Using Neck Dissection-Driven Selection to Improve Quality of Life for Low Risk Patients With HPV+ Oropharyngeal Squamous Cell Cancer

40 enrolled 11 charts

Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT03418792 2023-05-31

Functional Sparing of Salivary Glands Using MRI Sialography for Patients Undergoing Definitive Radiation Therapy for Head and Neck Cancers of the Oropharynx

40 enrolled

Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT05698667 2023-05-06

Outpatient Ultrasound for the Diagnostic Work-up of Oropharynx Cancer

26 enrolled

Oropharyngeal Neoplasms, Tonsillar Neoplasms

NCT03427411 2023-03-28

M7824 in Subjects With HPV Associated Malignancies

GastrointestinalGenitourinaryGynecologicHead & Neck

57 enrolled 20 charts

Anus Neoplasms, Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms

NCT04189107 2023-03-16

Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP & OSAS

18 enrolled

Agnosia, Head and Neck Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Pain, Postoperative

NCT00765791 2022-06-09

2BN2B

40 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT00964977 2022-02-25

Effectiveness of Adjuvant Radiotherapy in Small Oropharyngeal Squamous Cell Cancer and Single Lymph Node Metastasis.

209 enrolled

Head and Neck Neoplasms, Lymphatic Metastasis, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03269344 2022-01-26

Gabapentin for the Reduction of Radiation Therapy Induced Pain During the Treatment of Oropharyngeal Cancer

65 enrolled 18 charts

Oropharyngeal Neoplasms

NCT03096808 2021-10-26

Adaptive Radiotherapy for Head and Neck Cancer

64 enrolled

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Paranasal Sinus Neoplasms

NCT02981862 2021-08-31

CaptHPV

GastrointestinalGenitourinaryGynecologicHead & Neck

100 enrolled

Anus Neoplasms, Uterine Cervical Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms, Vulvar Neoplasms, Papillomavirus Infections

NCT01173692 2021-08-20

Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Randomized Study.

47 enrolled 7 charts

cyclopia sequence, Oropharyngeal Neoplasms

NCT01874587 2021-07-27

ARTIX

132 enrolled

Oropharyngeal Neoplasms, Xerostomia

NCT02405000 2021-04-23

Improving Trans-oral Surgical Outcomes Through Intra-operative Image Guidance

23 enrolled

Oropharyngeal Neoplasms

NCT02412241 2021-03-03

Establishing Lymphedema and Fibrosis Measures in Oral Cancer Patients

118 enrolled

Fibrosis, Lymphedema, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03435471 2021-01-27

Outcomes of Prophylactic Swallowing Therapy in Patients Undergoing Definitive Chemoradiation for Head and Neck Cancer

30 enrolled

Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT00490282 2020-12-30

A Pilot Trial of Image-Guided Adaptive Radiotherapy for Head and Neck Cancer

25 enrolled 4 charts

Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT03049280 2020-10-06

Prospective, Multicenter da Vinci® SP™ Surgical System TORS Study

33 enrolled 8 charts

Oropharyngeal Neoplasms

NCT01440270 2020-05-05

Neo-adjuvant Erbitux-based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer

145 enrolled

Mouth Neoplasms, Oropharyngeal Neoplasms

NCT00158678 2020-04-15

IMRT Plus Cisplatin Versus Conventional Radiotherapy Plus Cisplatin in Stage III-IV HNSCC

310 enrolled

Hypopharyngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT00524017 2020-03-12

Cetuximab in Treating Patients With Precancerous Lesions of the Upper Aerodigestive Tract

Head & NeckOther neoplasm

35 enrolled 6 charts

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Precancerous Conditions, Salivary Gland Neoplasms

NCT01469429 2020-02-20

Phase 1b Food Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer.

Phase 1/2 Completed

70 enrolled

Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Paranasal Sinus Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms

NCT02159703 2019-11-21

A Single-arm Phase II Study of Post-Transoral Robotic Surgery (TORS) Alone to the Primary Tumor Site and Selective Neck Dissection (SND) Followed by Adjuvant Radiation Therapy (+/- Chemotherapy) to the Regional Nodes for Advanced Stage, Human Papilloma Virus (HPV) Positive, Oropharyngeal Cancer

60 enrolled 9 charts

Margins of Excision, Oropharyngeal Neoplasms

NCT02277548 2019-11-21

A Pilot Study at a Single-Institution of Pregabalin in the Management of Mucositis Pain in Patients Undergoing Chemoradiation Therapy to the Head and Neck.

20 enrolled 10 charts

Oropharyngeal Neoplasms

NCT00656513 2019-11-19

Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer

Phase 2/3 Completed

196 enrolled 13 charts

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms, Xerostomia

NCT03346915 2019-10-09

Integrating a Health Information Technology System for Primary and Secondary Cervical Cancer Prevention