Clinical Trials

54 enrolled

Phase 2 Active not recruiting

Rectal Neoplasms

NCT05009069 2026-01-22

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

58 enrolled

Phase 2 Active not recruiting

Rectal Neoplasms

NCT00335816 2026-01-14

Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

248 enrolled

Phase 2 Active not recruiting

Rectal Neoplasms, Colorectal Neoplasms

NCT03921684 2026-01-05

Trial of Nivolumab With FOLFOX After Chemoradiation in Rectal Cancer Patients

29 enrolled

Rectal Neoplasms

NCT07162714 2025-09-09

STAR

30 enrolled

Rectal Neoplasms

NCT06884670 2025-09-08

Assessment of Efficacy and Safety of PD-1 Monoclonal Antibody Combined With IL-2 and CapeOX in Neoadjuvant Therapy for Locally Advanced Rectal Cancer Prior to Surgery: A Prospective, Multi-center, Randomized Controlled Study

130 enrolled

Rectal Neoplasms

NCT05024097 2025-08-27

PANTHER

43 enrolled

Rectal Neoplasms

NCT05515796 2025-08-24

Multi-omics Sequencing in Neoadjuvant Immunotherapy of Gastrointestinal Tumors

200 enrolled

Rectal Neoplasms, Stomach Neoplasms

NCT06780787 2025-06-26

FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

26 enrolled

Rectal Neoplasms

NCT06949098 2025-05-29

Tumor Local Excision +Postoperative Adjuvant Chemoradiotherapy for T1-2N0M0 Low/Ultra-Low Rectal Cancer

60 enrolled

Rectal Neoplasms

NCT06919510 2025-04-09

A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer

90 enrolled

Rectal Neoplasms

NCT04503694 2025-03-05

REGINA

72 enrolled

Rectal Neoplasms

NCT01643070 2025-02-25

Preoperative CRT With or Without Induction Chemotherapy for Rectal Cancer With Liver Metastases

38 enrolled 16 charts

Rectal Neoplasms

NCT03565029 2024-12-27

NO-CUT

180 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT06390982 2024-04-30

Organ Preservation With Tislelizumab and Total Neoadjuvant Therapy in Patients With Low Rectal Cancer: RELIEVE -01 Study

46 enrolled

Rectal Neoplasms

NCT06304545 2024-03-12

Treatment of Rectal Cancer With Long-term Concurrent Chemoradiotherapy Combined With Camrelizumab

48 enrolled

Rectal Neoplasms

NCT03729687 2023-11-30

LARCT-US

280 enrolled

Rectal Neoplasms

NCT05868317 2023-05-22

Induction Chemotherapy Followed by Short Course Radiotherapy in Rectal Cancer

70 enrolled

Rectal Neoplasms

NCT03299660 2023-03-16

Avelumab With Chemoradiation in Locally Advanced Rectal Cancer

37 enrolled

Rectal Neoplasms

NCT05274945 2022-03-11

Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer

58 enrolled

Rectal Neoplasms

NCT00308516 2021-12-10

5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer

66 enrolled 6 charts

Rectal Neoplasms, Colorectal Neoplasms

NCT01481545 2021-02-03

BRANCH

62 enrolled 13 charts

Rectal Neoplasms

NCT00006366 2020-10-22

Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum

Rectal Neoplasms, Colorectal Neoplasms

NCT00021398 2020-06-05

Radiation Therapy and Chemotherapy Followed by Surgery and Combination Chemotherapy in Treating Patients With Rectal Cancer

23 enrolled

Rectal Neoplasms, Colorectal Neoplasms

NCT02887313 2020-05-04

FOTAC

200 enrolled

Rectal Neoplasms

NCT00081289 2020-02-27

Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy in Treating Patients Who Are Undergoing Surgical Resection for Locally Advanced Rectal Cancer

146 enrolled 23 charts

Rectal Neoplasms, Colorectal Neoplasms

NCT00541112 2020-02-11

Radiation Therapy, Chemotherapy, and Cetuximab Followed by Surgery, Chemotherapy, and Cetuximab in Treating Patients With Locally Advanced or Metastatic Rectal Cancer That Can Be Removed by Surgery

19 enrolled

Rectal Neoplasms, Colorectal Neoplasms

NCT03022734 2020-01-13

Short Course Radiotherapy, Unresectable Rectal Cancer, Liver Metastasis

40 enrolled

Neoplasm Metastasis, Rectal Neoplasms

NCT00828672 2019-07-10

AXEBEAM

84 enrolled 19 charts

Postoperative Complications, Rectal Neoplasms

NCT00321685 2019-03-27

Bevacizumab, Radiation Therapy, and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Locally Advanced Nonmetastatic Rectal Cancer

57 enrolled 10 charts

Rectal Neoplasms

NCT00613080 2018-09-25

Combination Chemotherapy and Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Locally Advanced Rectal Cancer

79 enrolled 12 charts

Rectal Neoplasms, Colorectal Neoplasms

NCT03561142 2018-06-19

CAO/ARO/AIO-16

94 enrolled

Rectal Neoplasms

NCT00686166 2018-05-18

S0713: Oxaliplatin, Capecitabine, Cetuximab, and RT Followed By Surgery in Pts W/Stage II or III Rectal Cancer

83 enrolled 8 charts

Rectal Neoplasms, Colorectal Neoplasms

NCT00114231 2018-03-29

Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Stage I Rectal Cancer

90 enrolled 10 charts

Rectal Neoplasms, Colorectal Neoplasms

NCT02353858 2018-02-13

HT01

78 enrolled

Hyperthermia, Pathologic Complete Response, Rectal Neoplasms

NCT01729923 2018-01-16

ADAPT

27 enrolled 10 charts

Colonic Neoplasms, Rectal Neoplasms

NCT02473094 2017-11-28

NEOMETRE

3 enrolled

Adenocarcinoma, Carcinoma, Rectal Neoplasms

NCT00625183 2017-11-17

Capecitabine, Oxaliplatin, Selenomethionine, and Radiation Therapy in Treating Patients Undergoing Surgery For Newly Diagnosed Stage II or III Rectal Adenocarcinoma

5 enrolled 6 charts

Rectal Neoplasms, Colorectal Neoplasms

NCT00004005 2017-04-26

Irinotecan Followed By Fluorouracil and Leucovorin in Treating Patients With Stage III or Stage IV Colorectal Carcinoma (Cancer), Other Refractory Carcinoma, or Metastatic Adenoma (Cancer) of Unknown Primary Origin

12 enrolled

Colonic Neoplasms, Neoplasms, Unknown Primary, Rectal Neoplasms, Colorectal Neoplasms

NCT01273051 2017-04-14

CARTS

55 enrolled

Rectal Neoplasms

NCT02586610 2017-01-20

Trial of Chemoradiation and Pembrolizumab in Patients With Rectal Cancer

Phase 2 Withdrawn

Rectal Neoplasms

NCT00081224 2016-12-15

Neoadjuvant Celecoxib and Capecitabine Combined With Pelvic Irradiation in Treating Patients With Stage II or Stage III Adenocarcinoma (Cancer) of the Rectum

3 enrolled

Rectal Neoplasms, Colorectal Neoplasms

NCT00527111 2016-11-03

Pre-op Rectal ChemoRad +/- Cetuximab

139 enrolled 12 charts

Rectal Neoplasms

NCT01043484 2016-10-19

AVAXEL

90 enrolled

Rectal Neoplasms

NCT01263171 2016-09-21

COPERNICUS

60 enrolled

Rectal Neoplasms, Colorectal Neoplasms

NCT02723253 2016-03-30

Concurrent Chemoradiation With Concomitant Boost In Locally Advanced Rectal Cancer

18 enrolled

Rectal Neoplasms

NCT01554059 2014-11-10

New Beat

25 enrolled

Adenocarcinoma, Rectal Neoplasms

NCT00967655 2014-01-10

Capecitabine, Panitumumab, and Radiation Therapy With or Without Irinotecan Hydrochloride in Treating Patients Undergoing Surgery for Localized Rectal Cancer

54 enrolled

Rectal Neoplasms, Colorectal Neoplasms

NCT00909987 2013-10-11

Study of Neoadjuvant CT With Selective Radiotherapy in Patients With Intermediate-Risk Cancer Rectum

46 enrolled