Clinical Trials Browser

Interventional × Rectal Neoplasms × Radiotherapy × Clear all

NCT04751370 2026-03-18

Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT04643366 2026-01-27

Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05009069 2026-01-22

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT00335816 2026-01-14

Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT05108428 2026-01-08

Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma

Phase EARLY_PHASE1 Active not recruiting

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT03921684 2026-01-05

Trial of Nivolumab With FOLFOX After Chemoradiation in Rectal Cancer Patients

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT07162714 2025-09-09

STAR

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT06884670 2025-09-08

Assessment of Efficacy and Safety of PD-1 Monoclonal Antibody Combined With IL-2 and CapeOX in Neoadjuvant Therapy for Locally Advanced Rectal Cancer Prior to Surgery: A Prospective, Multi-center, Randomized Controlled Study

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05024097 2025-08-27

PANTHER

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05515796 2025-08-24

Multi-omics Sequencing in Neoadjuvant Immunotherapy of Gastrointestinal Tumors

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms, Stomach Neoplasms

NCT04525989 2025-08-20

PRORECT

Phase NA Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06834126 2025-07-18

Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial

Phase 1 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06780787 2025-06-26

FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06501053 2025-06-06

CORRECT

Phase NA Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06949098 2025-05-29

Tumor Local Excision +Postoperative Adjuvant Chemoradiotherapy for T1-2N0M0 Low/Ultra-Low Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06919510 2025-04-09

A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT02945566 2025-03-27

STAR-TREC

Phase 2/3 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT04503694 2025-03-05

REGINA

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT04406857 2025-02-26

Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer

Phase 1 Terminated

1 enrolled 7 charts

Gastrointestinal

Rectal Neoplasms

NCT01643070 2025-02-25

Preoperative CRT With or Without Induction Chemotherapy for Rectal Cancer With Liver Metastases

Phase 2 Completed

38 enrolled 16 charts

Gastrointestinal

Rectal Neoplasms

NCT06831981 2025-02-18

ARO 2024-13

Phase NA Recruiting

Gastrointestinal

Hyperthermia, Rectal Neoplasms

NCT03916510 2025-02-06

CEDAR

Phase 1 Completed

12 enrolled 13 charts

Gastrointestinal

Adenoviridae Infections, Rectal Neoplasms

NCT06758830 2025-01-09

Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.

Phase 2/3 Recruiting

Gastrointestinal

Low Anterior Resection Syndrome, Fatigue, Postoperative Complications, Radiation Injuries, Rectal Neoplasms

NCT03565029 2024-12-27

NO-CUT

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT03300544 2024-05-23

Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer

Phase 1 Terminated

3 enrolled 9 charts

Gastrointestinal

Rectal Neoplasms

NCT06390982 2024-04-30

Organ Preservation With Tislelizumab and Total Neoadjuvant Therapy in Patients With Low Rectal Cancer: RELIEVE -01 Study

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT06304545 2024-03-12

Treatment of Rectal Cancer With Long-term Concurrent Chemoradiotherapy Combined With Camrelizumab

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT01769222 2024-01-24

Ipilimumab and Local Radiation for Selected Solid Tumors

Phase 1 Terminated

3 enrolled 5 charts

DermatologicGastrointestinalLymphoidOther hematologic neoplasm

Burkitt Lymphoma, Colonic Neoplasms, Immunoblastic Lymphadenopathy, Leukemia, Hairy Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Melanoma, Mycosis Fungoides, Rectal Neoplasms, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, T-Cell, Peripheral, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Intraocular Lymphoma

NCT02528175 2023-12-07

Magnetic Resonance-Guided High Intensity Focused Ultrasound for Recurrent Rectal Cancer

Phase NA Completed

Gastrointestinal

Rectal Neoplasms

NCT03729687 2023-11-30

LARCT-US

Phase 2 Unknown

Gastrointestinal

Rectal Neoplasms

NCT01740648 2023-09-18

Trametinib, Fluorouracil, and Radiation Therapy Before Surgery in Treating Patients With Stage II-III Rectal Cancer

Phase 1 Completed

Gastrointestinal

Rectal Neoplasms

NCT06035133 2023-09-13

Treatment of Low Locally Advanced Rectal Cancer With Radiotherapy Removal TNT Plus Neoadjuvant Therapy

Phase NA Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT05868317 2023-05-22

Induction Chemotherapy Followed by Short Course Radiotherapy in Rectal Cancer

Phase 2 Unknown

Gastrointestinal

Rectal Neoplasms

NCT02288195 2023-05-12

CONVERT: Neoadjuvant Chemotherapy Alone Versus Preoperative Chemoradiation for Locally Advanced Rectal Cancer Patients

Phase 3 Unknown

Gastrointestinal

Rectal Neoplasms

NCT03299660 2023-03-16

Avelumab With Chemoradiation in Locally Advanced Rectal Cancer

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT02910843 2023-01-10

RECAP

Phase 1 Terminated

Gastrointestinal

Rectal Neoplasms

NCT03297710 2023-01-05

TAS-102 and Radiation Therapy in Treating Patients With Rectal Cancer That Is Locally Recurrent, Metastatic, or Cannot Be Removed by Surgery

Phase 1 Completed

Gastrointestinal

Rectal Neoplasms

NCT02935309 2022-05-31

Capecitabine and Lenvatinib With External Radiation in Rectal Adenocarcinoma

Phase 1 Completed

Gastrointestinal

Carcinoma, Rectal Neoplasms

NCT05274945 2022-03-11

Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT02465593 2022-01-11

A Study of PEP503(Radio-enhancer) With Radiotherapy and Chemotherapy for Patients With Rectal Cancer

Phase 1/2 Terminated

Gastrointestinal

Rectal Neoplasms

NCT00308516 2021-12-10

5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer

Phase 2 Completed

66 enrolled 6 charts

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT01134601 2021-12-01

A Phase I Study of AZD6244 in Combination With Capecitabine and Radiotherapy in Locally Advanced Adenocarcinoma of the Rectum

Phase 1 Terminated

1 enrolled 7 charts

Gastrointestinal

Rectal Neoplasms

NCT00227747 2021-02-17

Radiation Therapy and Capecitabine With or Without Oxaliplatin in Treating Patients Who Are Undergoing Surgery for Stage II or Stage III Rectal Cancer

Phase 3 Completed

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT04747951 2021-02-15

Total Neoadjuvant Therapy in Rectal Cancer Treatment

Phase 4 Unknown

Gastrointestinal

Rectal Neoplasms

NCT04103697 2021-02-09

RuCorT-01

Phase 3 Unknown

Gastrointestinal

Rectal Neoplasms

NCT04134897 2021-02-09

RuCorT-02

Phase 3 Unknown

Gastrointestinal

Rectal Neoplasms

NCT04135313 2021-02-09

RuCorT-03

Phase 3 Unknown

Gastrointestinal

Rectal Neoplasms

NCT01481545 2021-02-03

BRANCH

Phase 2 Completed

62 enrolled 13 charts

Gastrointestinal

Rectal Neoplasms

NCT01224392 2020-12-30

RectumSIB

Phase 3 Completed

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT04231552 2020-11-30

Preoperative Short Course Radiotherapy With Chemotherapy and Camerelizumab in Locally Advanced Rectal Cancer

Phase 1/2 Unknown

Gastrointestinal

Rectal Neoplasms