Clinical Trials Browser

Rectal Neoplasms

NCT05217446 2026-03-18

SEAMARK

Phase 2 Active not recruiting

107 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05673772 2026-02-12

SOLAR

Phase 2 Active not recruiting

364 enrolled

Gastrointestinal

Rectal Neoplasms

NCT04963283 2026-02-10

Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer

Phase 2 Active not recruiting

48 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05009069 2026-01-22

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

Phase 2 Active not recruiting

58 enrolled

Gastrointestinal

Rectal Neoplasms

NCT00335816 2026-01-14

Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

Phase 2 Active not recruiting

248 enrolled

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT05723562 2026-01-08

AZUR-1

Phase 2 Active not recruiting

154 enrolled

Gastrointestinal

Rectal Neoplasms

NCT03921684 2026-01-05

Trial of Nivolumab With FOLFOX After Chemoradiation in Rectal Cancer Patients

Phase 2 Active not recruiting

29 enrolled

Gastrointestinal

Rectal Neoplasms

NCT07160647 2025-12-02

Neo-IT

Phase 2 Active not recruiting

29 enrolled

Gastrointestinal

Rectal Neoplasms

NCT07127497 2025-11-21

Clinical Study on the Safety and Relationship of Sintilimab Combined With Chemotherapy in Neoadjuvant Treatment of Locally Advanced Rectal Adenocarcinoma

Phase 2 Active not recruiting

50 enrolled

Gastrointestinal

Rectal Neoplasms

NCT01941641 2025-11-17

Colon Neoadjuvant FOLFOXIRI Study

Phase 2 Active not recruiting

40 enrolled

Gastrointestinal

Rectal Neoplasms

NCT03997435 2025-11-17

FOLFOXIRI With or Without Intensification for Rectal Cancer

Phase 2 Active not recruiting

72 enrolled

Gastrointestinal

Rectal Neoplasms

NCT06640049 2025-11-17

China AZUR-1

Phase 2 Active not recruiting

23 enrolled

Gastrointestinal

Rectal Neoplasms

NCT05856305 2025-09-26

SCOTCH

Phase 2 Active not recruiting

76 enrolled

Gastrointestinal

Rectal Neoplasms

NCT02008656 2025-08-27

Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management

Phase 2 Active not recruiting

358 enrolled

Gastrointestinal

Rectal Neoplasms

NCT00492999 2025-08-17

Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Phase 2 Active not recruiting

64 enrolled

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT04864067 2025-07-01

NOAHS-ARC

Phase 2 Active not recruiting

73 enrolled

Gastrointestinal

Adenocarcinoma, Rectal Neoplasms

NCT04017455 2025-06-08

TARZAN

Phase 2 Active not recruiting

38 enrolled

Gastrointestinal

Rectal Neoplasms

NCT03548961 2025-04-04

Organ Preservation in Early Rectal Cancer Patients

Phase 2 Active not recruiting

19 enrolled

Gastrointestinal

Rectal Neoplasms

NCT03992456 2024-05-21

Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer

Phase 2 Active not recruiting

12 enrolled 16 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04543695 2024-03-26

A Study of Total Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer

Phase 2 Active not recruiting

255 enrolled

Gastrointestinal

Rectal Neoplasms

NCT03840239 2023-10-25

TESS

Phase 2 Active not recruiting

98 enrolled

Gastrointestinal

Rectal Neoplasms

NCT03391843 2018-01-05

Neoadjuvant Chemotherapy Combined With Cetuximab for EGFR Wild Type Locally Advanced Rectal Cancer

Phase 2 Active not recruiting

100 enrolled

Gastrointestinal

Rectal Neoplasms

Clinical Trials

Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer

SEAMARK

SOLAR

Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

AZUR-1

Trial of Nivolumab With FOLFOX After Chemoradiation in Rectal Cancer Patients

Neo-IT

Clinical Study on the Safety and Relationship of Sintilimab Combined With Chemotherapy in Neoadjuvant Treatment of Locally Advanced Rectal Adenocarcinoma

Colon Neoadjuvant FOLFOXIRI Study

FOLFOXIRI With or Without Intensification for Rectal Cancer

China AZUR-1

SCOTCH

Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management

Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

NOAHS-ARC

TARZAN

Organ Preservation in Early Rectal Cancer Patients

Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer

A Study of Total Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer

TESS

Neoadjuvant Chemotherapy Combined With Cetuximab for EGFR Wild Type Locally Advanced Rectal Cancer