Clinical Trials Browser

Terminated × Interventional × Rectal Neoplasms × Clear all

NCT06625515 2026-02-24

First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumors, and Molecularly Defined Cancers

Phase 1 Terminated

GastrointestinalGynecologic

Colonic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms, Microsatellite Instability

NCT04294160 2025-12-24

A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer

Phase 1 Terminated

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT04827732 2025-09-29

IMPARC

Phase NA Terminated

15 enrolled 16 charts

Gastrointestinal

Rectal Neoplasms

NCT00766142 2025-08-29

COCHISE

Phase 2 Terminated

18 enrolled 9 charts

GastrointestinalGynecologic

Colonic Neoplasms, Peritoneal Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05010850 2025-07-03

SAFE-2

Phase NA Terminated

18 enrolled 10 charts

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT04926324 2025-06-29

A Safety Study Adding Niraparib and Dostarlimab to Radiation Therapy for Rectal Cancers

Phase 1/2 Terminated

Gastrointestinal

Rectal Neoplasms

NCT04108481 2025-03-28

iRE-C

Phase 1 Terminated

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05179837 2025-03-19

Endoscopic Optical Coherence Tomography for Screening and Diagnosis of Colorectal Precancerous and Malignant Polyps

Phase NA Terminated

36 enrolled 9 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT04316013 2025-03-14

Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: the VAPOR-C Trial

Phase 3 Terminated

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Rectal Neoplasms

NCT04406857 2025-02-26

Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer

Phase 1 Terminated

1 enrolled 7 charts

Gastrointestinal

Rectal Neoplasms

NCT04213794 2025-02-20

TOASTIT

Phase EARLY_PHASE1 Terminated

GastrointestinalGynecologicOther solid neoplasmSarcomaThoracic

Mesothelioma, Malignant, Colonic Neoplasms, Fallopian Tube Neoplasms, Liposarcoma, Ovarian Neoplasms, Pelvic Neoplasms, Rectal Neoplasms, Rhabdomyosarcoma, Sarcoma, Stomach Neoplasms, Desmoplastic Small Round Cell Tumor

NCT05164315 2024-12-05

Comparison Between Tailored Surgery Versus Total Mesorectal Excision in ycT2-3N0M0

Phase NA Terminated

Gastrointestinal

Rectal Neoplasms

NCT03300544 2024-05-23

Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer

Phase 1 Terminated

3 enrolled 9 charts

Gastrointestinal

Rectal Neoplasms

NCT06164691 2024-05-21

Blue and Amber Light Exposure in Patients With Rectal and Pancreatic Cancer

Phase NA Terminated

2 enrolled 4 charts

Gastrointestinal

Pancreatic Neoplasms, Rectal Neoplasms

NCT01605318 2024-01-24

Study of Labetuzumab Govitecan in Participants With Metastatic Colorectal Cancer

Phase 1/2 Terminated

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01769222 2024-01-24

Ipilimumab and Local Radiation for Selected Solid Tumors

Phase 1 Terminated

3 enrolled 5 charts

DermatologicGastrointestinalLymphoidOther hematologic neoplasm

Burkitt Lymphoma, Colonic Neoplasms, Immunoblastic Lymphadenopathy, Leukemia, Hairy Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Melanoma, Mycosis Fungoides, Rectal Neoplasms, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, T-Cell, Peripheral, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Intraocular Lymphoma

NCT04066894 2023-08-14

Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study

Phase 2 Terminated

3 enrolled 5 charts

GastrointestinalGenitourinaryGynecologic

Low Anterior Resection Syndrome, Anus Neoplasms, Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Ovarian Neoplasms, Pelvic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT04139967 2023-07-14

Study of Short Course Radiation Therapy for Elderly Patients With Rectal Cancer

Phase NA Terminated

Gastrointestinal

Rectal Neoplasms

NCT00303628 2023-07-06

Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III Rectal Cancer

Phase 3 Terminated

355 enrolled 11 charts

Gastrointestinal

Rectal Neoplasms

NCT01347645 2023-06-22

Irinotecan Plus E7820 Versus FOLFIRI in Second-Line Therapy in Patients With Locally Advanced or Metastatic Colon or Rectal Cancer

Phase 1/2 Terminated

82 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT03796702 2023-04-26

Early Versus Late Closure of Preventive Ileostomy

Phase NA Terminated

Gastrointestinal

Rectal Neoplasms

NCT01160926 2023-04-24

DREAMtherapy

Phase 1 Terminated

Gastrointestinal

Rectal Neoplasms

NCT04177602 2023-02-22

Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II TARC Trial

Phase 1/2 Terminated

Gastrointestinal

Rectal Neoplasms

NCT04150705 2023-02-14

PET/MR for Rectal Cancer Treatment Monitoring and Surveillance

Phase NA Terminated

14 enrolled 6 charts

Gastrointestinal

Rectal Neoplasms

NCT02910843 2023-01-10

RECAP

Phase 1 Terminated

Gastrointestinal

Rectal Neoplasms

NCT05018325 2022-08-31

Assessing Effect of Withdrawal Time on Adenoma Detection Rate for Screening Colonoscopy

Phase NA Terminated

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02445456 2022-07-06

SentiRect

Phase NA Terminated

15 enrolled 14 charts

Gastrointestinal

Rectal Neoplasms

NCT02933944 2022-01-26

Exploratory Study of TG02-treatment as Monotherapy or in Combination With Pembrolizumab to Assess Safety and Immune Activation in Patients With Locally Advanced Primary and Recurrent Oncogenic RAS Exon 2 Mutant Colorectal Cancer

Phase 1 Terminated

6 enrolled 11 charts

Gastrointestinal

Rectal Neoplasms

NCT02465593 2022-01-11

A Study of PEP503(Radio-enhancer) With Radiotherapy and Chemotherapy for Patients With Rectal Cancer

Phase 1/2 Terminated

Gastrointestinal

Rectal Neoplasms

NCT01285102 2021-12-20

Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal Cancer

Phase 1 Terminated

4 enrolled 6 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT01995396 2021-12-16

HAPIrect

Phase NA Terminated

Gastrointestinal

Fecal Incontinence, Postoperative Complications, Rectal Neoplasms

NCT01134601 2021-12-01

A Phase I Study of AZD6244 in Combination With Capecitabine and Radiotherapy in Locally Advanced Adenocarcinoma of the Rectum

Phase 1 Terminated

1 enrolled 7 charts

Gastrointestinal

Rectal Neoplasms

NCT02319304 2021-11-04

GCC 1314

Phase 2 Terminated

3 enrolled 8 charts

Gastrointestinal

Rectal Neoplasms

NCT00314353 2021-10-06

Study of Bevacizumab Combined With Capecitabine and Either Oxaliplatin or Irinotecan as First Course of Treatment for Patients With Colorectal Cancer That Has Spread Beyond the Colon

Phase 2 Terminated

7 enrolled 5 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02163785 2021-10-01

APPRO

Phase NA Terminated

Gastrointestinal

Rectal Neoplasms

NCT03280277 2021-09-10

Ferumoxytol-Enhanced MRI in Imaging Lymph Nodes in Patients With Locally Advanced Rectal Cancer

Phase EARLY_PHASE1 Terminated

Gastrointestinal

Rectal Neoplasms

NCT00041691 2021-08-19

Safety Study of 90Y-hMN14 to Treat Colorectal Cancer Patients With Limited Residual Disease After Surgery

Phase 1 Terminated

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01437514 2021-06-07

Effective Study of Preoperative Short-course Radiotherapy for the Advanced Resectable Rectal Cancer

Phase 2/3 Terminated

Gastrointestinal

Neoplasm Metastasis, Rectal Neoplasms

NCT01280643 2021-03-15

Combination Chemotherapy and Cetuximab or Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

Phase NA Terminated

3 enrolled 8 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02550743 2021-03-12

BrUOG 302:BYL719, Capecitabine and Radiation for Rectal Cancer: A Brown University Oncology Research Group Study

Phase 1 Terminated

7 enrolled 7 charts

Gastrointestinal

Neoplasm Metastasis, Rectal Neoplasms

NCT00005944 2021-02-17

Second-look Surgery With or Without Intraperitoneal Chemotherapy in Treating Patients With Recurrent Colorectal Cancer

Phase 2 Terminated

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT02614157 2021-02-01

Lateral Lymph Node Dissection After Neoadjuvant Chemo-radiation in Advanced Low Rectal Cancer

Phase NA Terminated

Gastrointestinal

Neoplasm Metastasis, Rectal Neoplasms, Recurrence

NCT03170115 2020-12-17

ICAR

Phase 2 Terminated

Gastrointestinal

Rectal Neoplasms

NCT00023868 2020-12-02

Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver (6655)

Phase 3 Terminated

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT02538913 2020-11-17

Exercise Training for Rectal Cancer Patients

Phase NA Terminated

GastrointestinalOther

Fecal Incontinence, Motor Activity, Rectal Neoplasms, Sexual Dysfunction, Physiological, Urinary Incontinence

NCT02010567 2020-11-03

Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer

Phase 1/2 Terminated

32 enrolled 18 charts

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT02205307 2020-06-24

PILLAR III

Phase NA Terminated

347 enrolled 18 charts

Gastrointestinal

Rectal Neoplasms

NCT03258541 2020-05-15

Organ-sparing With TraceIT® for Rectal Cancer Radiotherapy

Phase NA Terminated

Gastrointestinal

Rectal Neoplasms

NCT02052921 2020-05-11

Observation Versus Surgical Resection in Patients With Rectal Cancer Who Achieved Complete Clinical Response After Neoadjuvant Chemoradiotherapy

Phase NA Terminated

Gastrointestinal

Rectal Neoplasms

NCT01609231 2020-05-04

MK-0646-025

Phase 2 Terminated

11 enrolled 8 charts

Gastrointestinal

Rectal Neoplasms